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Synthesis and Activity Studies of Active Pharmaceutical Substances That Can Be Used in Cancer Treatment by Yozgat Bozok University Department of Chemistry

Yıl 2024, Cilt: 2 Sayı: 1, 1 - 5, 31.05.2024

Öz

Cancer treatment involves a range of treatments aimed at stopping or slowing the uncontrolled growth of abnormal cells in the body. These methods include surgical intervention, radiotherapy, chemotherapy, targeted drugs, and immunotherapy. Cancer treatment can be applied depending on the patient's type, stage, and general health condition. A multidisciplinary approach is taken during cancer treatment, which requires oncologists, surgeons, radiation specialists, and other healthcare professionals to work together. Treatment aims to destroy or control cancer cells, minimize side effects, and improve the patient's quality of life. In this article, Yozgat Bozok University's Department of Chemistry will provide information about the synthesis and activity studies of active pharmaceutical substances that can be used in cancer treatment

Kaynakça

  • İ. Koca, A. Özgür, K. Açikalin Coşkun, and Y. Tutar, "Synthesis and Anticancer Activity of Acyl Thioureas Bearing Pyrazole Moiety," Bioorg. Med. Chem., vol. 21, no. 13, pp. 3859–3865, Apr. 2013, doi: 10.1016/j.bmc.2013.04.021.
  • İ. Koca, M. Gümüş, A. Özgür, A. Dişli, and Y. Tutar, "A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton," Anti-Cancer Agents Med. Chem., vol. 15, no. 7, pp. 916–930, Sept. 2015, doi: 10.2174/1871520615666150407155623.
  • İ. Koca, A. Özgür, M. Er, M. Gümüş, K. Açikalin Coşkun, and Y. Tutar, "Design and Synthesis of Pyrimidinyl Acyl Thioureas as Novel Hsp90 Inhibitors in Invasive Ductal Breast Cancer and its Bone Metastasis," Eur. J. Med. Chem., vol. 122, pp. 280–290, Jun. 2016, doi: 10.1016/j.ejmech.2016.06.032.
  • M. Gümüş, A. Özgür, L. Tutar, A. Dişli, İ. Koca, and Y. Tutar, "Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis," Curr Pharm Biotechnol., vol. 17, no. 14, pp. 1231–1245, Nov. 2016, doi:10.2174/1389201017666161031105815.
  • E. G. Sağlam, S. Akkoç, Y. Zorlu, E. Bulat, and A. Akgün, “New Phenanthroline Nickel(II) Organodithio-Phosphorus Complexes: Syntheses, Structural Characterizations and In Vitro Cytotoxic Activity Studies,” Polyhedron, vol. 199, no. 115097, 1–13, Feb. 2021, doi: 10.1016/j.poly.2021.115097.
  • E. G. Sağlam, S. Akkoç, C. T. Zeyrek, H. Dal, and O. Tutsak, “New Heterobimetallic Nickel(II) Ferrocenyldithiophosphonato Complexes: Syntheses, Characterization, Antiproliferative Activity and X-ray, DFT, Molecular Docking Studies on Trans-Bis-[O-3-methyl-1-butyl-(ferrocenyl) Dithiophosphonato] Nickel(II),” Inorg. Chim. Acta, vol. 514, pp. 1–11, 2021, doi: 10.1016/j.ica.2020.119991.
  • İ. Koca, V. Kamaci, C. Özsoy, Y. Sert, İ. Kani, L. Tutar, and Y. Tutar, “Pyrazolyl-Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer,” ChemistrySelect, vol. 7, no. 19, May. 2022, pp. 1–10, doi: 10.1002/slct.202200359.
  • İ. E., Kıbrız, S. Akkoç, Y. Sert, Ü. Çay, and Ş. H. Üngören, "Synthesis, Antiproliferative Activity, Molecular Docking Studies of Hydrazone Functionalised Thioparabanic Acid and Rhodanine Analogues," Phosphorus Sulfur Silicon Relat. Elem., vol. 197, no. 9, pp. 918–926, Apr. 2022, doi: 10.1080/10426507.2022.2046578.
Yıl 2024, Cilt: 2 Sayı: 1, 1 - 5, 31.05.2024

Öz

Kaynakça

  • İ. Koca, A. Özgür, K. Açikalin Coşkun, and Y. Tutar, "Synthesis and Anticancer Activity of Acyl Thioureas Bearing Pyrazole Moiety," Bioorg. Med. Chem., vol. 21, no. 13, pp. 3859–3865, Apr. 2013, doi: 10.1016/j.bmc.2013.04.021.
  • İ. Koca, M. Gümüş, A. Özgür, A. Dişli, and Y. Tutar, "A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton," Anti-Cancer Agents Med. Chem., vol. 15, no. 7, pp. 916–930, Sept. 2015, doi: 10.2174/1871520615666150407155623.
  • İ. Koca, A. Özgür, M. Er, M. Gümüş, K. Açikalin Coşkun, and Y. Tutar, "Design and Synthesis of Pyrimidinyl Acyl Thioureas as Novel Hsp90 Inhibitors in Invasive Ductal Breast Cancer and its Bone Metastasis," Eur. J. Med. Chem., vol. 122, pp. 280–290, Jun. 2016, doi: 10.1016/j.ejmech.2016.06.032.
  • M. Gümüş, A. Özgür, L. Tutar, A. Dişli, İ. Koca, and Y. Tutar, "Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis," Curr Pharm Biotechnol., vol. 17, no. 14, pp. 1231–1245, Nov. 2016, doi:10.2174/1389201017666161031105815.
  • E. G. Sağlam, S. Akkoç, Y. Zorlu, E. Bulat, and A. Akgün, “New Phenanthroline Nickel(II) Organodithio-Phosphorus Complexes: Syntheses, Structural Characterizations and In Vitro Cytotoxic Activity Studies,” Polyhedron, vol. 199, no. 115097, 1–13, Feb. 2021, doi: 10.1016/j.poly.2021.115097.
  • E. G. Sağlam, S. Akkoç, C. T. Zeyrek, H. Dal, and O. Tutsak, “New Heterobimetallic Nickel(II) Ferrocenyldithiophosphonato Complexes: Syntheses, Characterization, Antiproliferative Activity and X-ray, DFT, Molecular Docking Studies on Trans-Bis-[O-3-methyl-1-butyl-(ferrocenyl) Dithiophosphonato] Nickel(II),” Inorg. Chim. Acta, vol. 514, pp. 1–11, 2021, doi: 10.1016/j.ica.2020.119991.
  • İ. Koca, V. Kamaci, C. Özsoy, Y. Sert, İ. Kani, L. Tutar, and Y. Tutar, “Pyrazolyl-Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer,” ChemistrySelect, vol. 7, no. 19, May. 2022, pp. 1–10, doi: 10.1002/slct.202200359.
  • İ. E., Kıbrız, S. Akkoç, Y. Sert, Ü. Çay, and Ş. H. Üngören, "Synthesis, Antiproliferative Activity, Molecular Docking Studies of Hydrazone Functionalised Thioparabanic Acid and Rhodanine Analogues," Phosphorus Sulfur Silicon Relat. Elem., vol. 197, no. 9, pp. 918–926, Apr. 2022, doi: 10.1080/10426507.2022.2046578.
Toplam 8 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Fiziksel Organik Kimya
Bölüm Reviews
Yazarlar

İbrahim Evren Kıbrız 0000-0001-6217-9585

Mehmet Yakan 0000-0003-4954-2073

Yayımlanma Tarihi 31 Mayıs 2024
Gönderilme Tarihi 5 Nisan 2024
Kabul Tarihi 22 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 2 Sayı: 1

Kaynak Göster

IEEE İ. E. Kıbrız ve M. Yakan, “Synthesis and Activity Studies of Active Pharmaceutical Substances That Can Be Used in Cancer Treatment by Yozgat Bozok University Department of Chemistry”, BJS, c. 2, sy. 1, ss. 1–5, 2024.