Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders

Abstract

Chronobiology is a field that studies the effects of time on biological systems. Periodicity is of particular interest. The master biological clock in the suprachiasmatic nucleus controls daily rhythms of core body temperature, rest-activity cycle, physiological and behavioral functions, psychomotor functions and mood in humans. The clock genes are involved in the generation of the circadian rhythms and the biological clock is synchronized to solar day by direct photic inputs. Various circadian rhythm abnormalities have been demonstrated in mood disorders such as unipolar depression, bipolar depression and seasonal affective disorder. Hypotheses involving circadian rhythm abnormalities related to the etiology of mood disorders have been raised. The resulting circadian rhythm changes can be measured and evaluated that these techniques can be used to identify subtypes of mood disorders associated with circadian rhythm changes. The data obtained from chronobiological studies reveal methods that manipulate circadian rhythms. The effects of light and melatonin on circadian rhythms are determined by these studies. Chronobiological research has been applied to the psychiatric clinic and light therapy has been used as a chronotherapeutic in the treatment of mood disorders. On the other hand, chronotherapeutic approaches with effects on circadian rhythms such as sleep deprivation therapy have been used in the treatment of mood disorders too. As a good example of translational psychiatry, chronobiological studies have been projected in the psychiatry clinic. It may be possible, the data obtained from the basic sciences are used in the diagnosis of mood disorders and in the treatment of psychiatric disorders as chronotherapeutic techniques. Developments in the field of chronobiology and data obtained from chronotherapeutics may enable the development of evidence-based diagnosis and treatment in psychiatry.

Keywords

• Chronotherapy, circadian rhythm, diagnosis, mood disorders, phototherapy, biological clocks

Kaynakça

1. 1. Rietveld WJ. Chronobiology. Horm Res 1990;33:53-7. 2. Monteleone P, Maj M. The circadian basis of mood disorders: recent developments and treatment implications. Eur Neuropsychopharmacol 2008;18:701-11.
2. 3. Gillette MU, Tischkau SA. Suprachiasmatic nucleus: the brain's circadian clock. Recent prog Horm Res 1999;54:33-58.
3. 4. Moore RY. Circadian rhythms: basic neurobiology and clinical applications. Annu Rev Med 1997;48:253-66.
4. 5. Vitaterna MH, Takahashi JS, Turek FW. Overview of circadian rhythms. National Institute on Alcohol Abuse and Alcoholism 2001;25:85-93.
5. 6. Bechtel W. Circadian Rhythms and Mood Disorders: Are the Phenomena and Mechanisms Causally Related? Front Psychiatry 2015;6:118.
6. 7. Alonso J, Angermeyer MC, Bernert S, Bruffaerts R, Brugha TS, Bryson H, et al. Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl 2004:21-7.
7. 8. Sher L. Etiology, pathogenesis, and treatment of seasonal and non-seasonal mood disorders: possible role of circadian rhythm abnormalities related to developmental alcohol exposure. Med Hypotheses 2004;62:797-801.
8. 9. Germain A, Kupfer DJ. Circadian rhythm disturbances in depression. Hum Psychopharmacol 2008;23:571-85.

9. 10. Milhiet V, Etain B, Boudebesse C, Bellivier F. Circadian biomarkers, circadian genes and bipolar disorders. J Physiol Paris 2011;105:183-9.
10. 11. Rosenthal NE, Sack DA, Gillin JC, Lewy AJ, Goodwin FK, Davenport Y, et al. Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 1984;41:72-80.
11. 12. Wehr TA, Duncan WC, Jr., Sher L, Aeschbach D, Schwartz PJ, Turner EH, et al. A circadian signal of change of season in patients with seasonal affective disorder. Arch Gen Psychiatry 2001;58:1108-14.
12. 13. Albrecht U. Circadian clocks and mood-related behaviors. Handb Exp Pharmacol 2013:227-39.
13. 14. Hampp G, Albrecht U. The circadian clock and mood-related behavior. Commun Integr Biol 2008;1:1-3.
14. 15. Jones CR, Huang AL, Ptacek LJ, Fu YH. Genetic basis of human circadian rhythm disorders. Exp Neurol 2013;243:28-33.
15. 16. Hidalgo MP, Caumo W, Posser M, Coccaro SB, Camozzato AL, Chaves ML. Relationship between depressive mood and chronotype in healthy subjects. Psychiatry Clin Neurosci 2009;63:283-90.
16. 17. Shirayama M, Shirayama Y, Iida H, Kato M, Kajimura N, Watanabe T, et al. The psychological aspects of patients with delayed sleep phase syndrome (DSPS). Sleep Med 2003;4:427-33.
17. 18. Drake CL, Roehrs T, Richardson G, Walsh JK, Roth T. Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers. Sleep 2004;27:1453-62.
18. 19. Levandovski R, Dantas G, Fernandes LC, Caumo W, Torres I, Roenneberg T, et al. Depression scores associate with chronotype and social jetlag in a rural population. Chronobiol Int 2011;28:771-8.
19. 20. Boivin DB. Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders. J Psychiatry Neurosci 2000;25:446-58.
20. 21. Maung HH. Diagnosis and causal explanation in psychiatry. Stud Hist Philos Biol Biomed Sci 2016;60:15-24.
21. 22. Banzato CE. Critical evaluation of current diagnostic systems. Indian J Psychiatry 2008;50:155-7.