Tenofovir in the Management of Chronic Hepatitis B Infection During Pregnancy

Abstract

Chronic hepatitis B infection has a worldwide distribution, with approximately 350 million infected persons. While become more of an issue during pregnancy concerning maternal and fetal well-being and the influence of pregnancy itself on the course of the disease; the natural history of chronic hepatitis B infection during pregnancy has not been clearly established. This paper reports the outcome of pregnancy in a patient with chronic hepatitis B infection who discontinued double antiviral treatment since she wanted to get pregnant but then was administered tenofovir disoproxil fumarate (TDF; 245 mg/day) monotherapy at the 32nd gestational week. Turkish Başlık: Gebelikte Kronik Hepatit B Enfeksiyonu Tedavisinde Tenofovir Anahtar Kelimeler: Tenofovir,Hepatit B, gebelik Kronik Hepatit B enfeksiyonu dünyada 350 milyon kişiyi etkilemiş yaygın bir enfeksiyondur. Gebelikte anne ve bebek sağlığı ve gebelik süreci için önemli bir sorun olan kronik Hepatit B enfeksiyonunun gebelikteki doğal seyri henüz açıkça tesbit edilememiştir. Bu yazı, Hepatit B enfeksiyonu için ikili antiviral tedavi almakta iken, gebelik planlamasıyla antiviral tedaviyi kesen bir hastanın, gebeliğin 32. haftasında tekrar tenofovir disoproxil fumarate (TDF; 245 mg/gün) tedavisine başlanması ile gebeliğin seyrini bildirmektedir.

Keywords

• Tenofovir, hepatitis B, pregnancy

Tenofovir in the Management of Chronic Hepatitis B Infection During Pregnancy

Öz

Kaynakça

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