Treatment Effects of Onion (Allium cepa) and Ginger (Zingiber officinale) on Sexual Behavior of Rat after Inducing an Antiepileptic Drug (lamotrigine)

Abstract

Objective: The aim of the present study was to evaluate the beneficial degree of sexual behavior in male rats after inducement of onion and ginger in lamotrigine receiving groups. Material and Methods: Wistar rats (n=70) (male=35, female=35) were allocated so that males were divided into seven groups: control (n=5) and test groups (n=35). Control group used normal Saline (3 cc for each rat). Lamotrigine group were given Lamotrigine (10 mg/kg). Onion group used onion fresh juice (3 cc for each rat/daily). Ginger group was fed on ginger powder (100 mg/kg/daily). Onion & Lamotrigine group used both onion juice (3 cc fresh onion juice for each rat/day) and Lamotrigine (10 mg/kg). Ginger & Lamotrigine group used both ginger powder (100 mg/kg/day) and Lamotrigine (10 mg/kg/day). Onion, ginger & Lamortigine group jointly used ginger powder (100 mg/kg/day) and onion juice (3 cc juice for each rat) and Lamotrigine (10 mg/kg/day). All groups were given treatments orally. For sexual behaviors, Estradiolbenzoate (50 microgram) and 6 hours before test (500 microgram) progesterone was injected to the female rats subcutaneously. Then rats were viewed for erection, ejaculation and cup. Results: There was maximum Serum total testosterone level in the onion group, there was maximum malondialdehyde (MDA) in the Lamotrigine group and there was maximum total antioxidant capacity in both the onion group and ginger group (p<0.05). Conclusion: Results revealed that administration of (100 mg/kg/day) of ginger powder, and freshly prepared onion juice (3 cc for each rat), significantly lowered the adverse effects of lamotrigine, and can have beneficial effects on sexual behavior in male rat. Turkish Başlık: Treatment Effects of Onion (Allium cepa) and Ginger (Zingiber officinale) on Sexual Behavior of Rat after Inducing an Antiepileptic Drug (lamotrigine) Anahtar Kelimeler: Allium cepa, antiepileptik, lamotrijin, cinsel davranış, Zingiber officinale Amaç: Bu çalışmanın amacı Lamotrijin alan gruplarda soğan ve zencefil başlandıktan sonra erkek ratların cinsel davranış düzeyi üzerine faydalı etkilerini değerlendirmekti. Materyal ve Metotlar: Wistar ratlar (n=70) (erkek=35, dişi=35), erkekler yedi gruba ayrılacak şekilde gruplandırıldı: kontrol (n=5) ve test grupları (n=35). Kontrol grubunda normal salin (her bir rat için 3 cc) kullanıldı. Lamotrijin grubuna Lamotrijin (10 mg/kg) verildi. Soğan grubuna taze soğan suyu (her rat için günlük 3 cc) verildi. Zencefil grubu zencefil tozu (100 mg/kg/gün) ile beslendi. Soğan+Lamotrijin grubu hem soğan suyu (her bir rat için günlük 3 cc taze soğan suyu) hem de Lamotrijin (10 mg/kg) kullandı. Zencefil+Lamotrijin grubu hem zencefil tozu (100 mg/kg/gün) hem de Lamotrijin (10 mg/kg/gün) kullandı. Soğan+zencefil+Lamortigine grubu zencefil tozu (100 mg/kg/gün), soğan suyu (her rat için 3 cc) ve Lamotrijini (10 mg/kg/gün) birlikte kullandı. Tüm gruplara tedaviler oral olarak verildi. Cinsel davranış için dişi ratlara subkutan olarak Östradiolbenzoat (50 mikrogram) ve testten 6 saat önce (500 mikrogram) progesteron enjekte edildi. Daha sonra ratlarda ereksiyon, ejakülasyon ve çiftleşme davranışı incelendi. Bulgular: Maksimum serum total testosteron seviyesi soğan grubunda, maksimum malondialdehid (MDA) seviyesi Lamotrijin grubunda ve maksimum total antioksidan kapasite hem soğan hem de zencefil grubunda mevcuttu (p<0.05). Sonuç: Bulgular zencefil tozu (100 mg/kg/gün) ve taze hazırlanmış soğan suyu (her rat için 3 cc) verilmesinin Lamotrijinin advers etkilerini anlamlı şekilde azalttığını ve erkek ratların cinsel davranışı üzerine faydalı etkileri olabileceğini gösterdi.

Keywords

• Allium cepa, antiepileptic, lamotrigine, sexual behavior, Zingiber officinale

Treatment Effects of Onion (Allium cepa) and Ginger (Zingiber officinale) on Sexual Behavior of Rat after Inducing an Antiepileptic Drug (lamotrigine)

Öz

Kaynakça

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