Clinical Features and Prognostic Factors of Hodgkin’s Lymphoma: A Single Center Experience

Yıl 2013, , 178 - 185, 01.02.2013

Saadettin Kılıçkap İbrahim Barışta Şükran Ülger İsmail Çelik Uğur Selek Ferah Yıldız Ayşe Kars Yavuz Özışık Gülten Tekuzman

https://doi.org/10.5152/balkanmedj.2012.110

Öz

Background: Hodgkin's lymphoma (HL) is a B cell lymphoma characterized by the presence of Reed-Sternberg cells. HL comprises 1% of all cancer cases and 14% of all lymphoma cases. Aims: We designed a retrospective study to investigate the clinical features and prognostic factors of HL patients diagnosed at an experienced oncology centre. Study Design: Retrospective study. Methods: Demographic characteristics, histopathological and clinical features, treatment modalities and response to treatment were obtained from hospital records. Dates of initial diagnosis, remission and relapse, last visit and death were recorded for survival analyses. Results: We analysed data of 391 HL patients (61% male, 39% female; mean age 35.7±15.1 years). The most common classical HL histological subtype was nodular sclerosing HL (NSHL) (42.7%). The most common stage was II 50.4%. The most common chemotherapy regimen was doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) (70.6%). Five and 10-year survival rates were 90% and 84%, respectively. Early-stage patients with good prognostic factors had better overall and relapse-free survival rates. The presence of “B” symptoms, albumin level, Eastern Cooperative Oncology Group (ECOG) performance score, and LDH were prognostic factors that affect the survival in both univariate and multivariate analyses. Conclusion: This is the first study that demonstrates the demographic, clinical and prognostic features of HL patients in Turkey, and provides a general picture of the HL patients in our country. Turkish Başlık: Hodgkin's Lenfomanın Klinik Özellikleri ve Prognostik Faktörler: Tek Merkez Deneyimi Anahtar Kelimeler: Hodgkin's lenfoma, tanı, prognoz, tedavi. Arka Plan: Hodgkin's lenfoma (HL) Reed-Sternberg hücreleri ile karakterize B hücreli bir lenfomadır. HL tüm kanser olgularının %1'ini ve tüm lenfomaların %14'ünü oluşturur. Amaç: Biz deneyimli bir onkoloji merkezinde tanı almış HL hastalarına ait klinik özellikleri ve prognostik faktörleri belirlemek için retrospektif bir çalışma planladık. Çalışma Tasarımı: Retrospektif çalışma. Yöntemler: Demografik özellikler, histopatolojik ve klinik özellikler, tedavi modaliteleri ve tedaviye cevap hastane kayıtlarından elde edildi. Sağkalım analizi için tanı, remisyon ve relaps, son vizit ve ölüm tarihleri kaydedildi. Bulgular: 391 (%61 erkek, %39 kadın; ortalama yaş 35.7±15.1 yıl) HL hastasına ait veriler analiz edildi. En sık görülen klasik HL histolojik subtip nodüler sklerozan HL (NSHL) (%42.7) idi. En sık görülen evre %50.4 ile evre II idi. En sık kullanılan kemoterapi rejimi doksorubisin, bleomisin, vinblastin ve dakarbazin (ABVD) (%70.6) idi. 5- ve 10-yıllık sağkalım oranları sırasıyla %90 ve %84'tü. Erken evre iyi prognostik faktörlü hastalar daha iyi genel ve hastalıksız sağkalım oranlarına sahipti. “B” semptomu, albümin düzeyi, Eastern Cooperative Oncology Group (ECOG) performans skoru ve LDH hem tek değişkenli hem de çok değişkenli analizlerde sağkalımı etkileyen prognostik faktörlerdi. Sonuç: Bu çalışma Türkiye'deki HL hastalarının demografik, klinik ve prognostik özelliklerini ortaya koyan ilk çalışmadır ve ülkemizdeki HL hastalarına genel bir bakış sağlamaktadır.

Anahtar Kelimeler

Hodgkin’s lymphoma, diagnosis, prognosis, treatment

Clinical Features and Prognostic Factors of Hodgkin’s Lymphoma: A Single Center Experience

Öz

Kaynakça

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