Seizures After Overdoses of Bupropion Intake

Abstract

Background: Bupropion is a new-generation monocyclic antidepressant that has been accidentally found to have potential effects on reducing nicotine addiction. It is structurally similar to stimulants such as amphetamine and inhibits dopamine and noradrenalin reuptake selectively. Case Reports: We report two cases with no history of epilepsy who took oral bupropion for depression and had generalised tonic-clonic type of seizures in their follow-ups. Conclusion: After an overdose of bupropion, clinical effects are seen primarily on the neurological, cardiovascular, and gastrointestinal systems. Neurological effects can include tremor, confusion, agitation, hallucinations, coma, and seizures. Turkish Başlık: Aşırı Dozda Bupropion Alımından Sonraki Nöbetler Anahtar Kelimeler: Bupropion, aşırı doz, nöbetler Arka plan: Bupropion nikotin bağımlılığını azaltmada potansiyel etkisinin olduğu tesadüfen bulunmuş yeni kuşak bir monosiklik antidepresandır. Bupropion yapısal olarak amfetamin gibi stimülanlara benzer olup dopamin ve noradreanlin geri alımını selektif olarak inhibe eder. Olgu Sunumu: Bu çalışmada daha önce epilepsi öyküsü olmayan ancak depresyon nedeniyle oral bupropion alan ve takiplerinde jeneralize tonik klonik tarzda nöbet geçiren iki olgu sunulmuştur. Sonuç: Bupropion yüksek doz alımından sonra klinik etkiler öncelikle nörolojik, kardiyovasküler ve gastrointestinal sistem üzerinedir. Nörolojik etkiler; tremor, konfüzyon, ajitasyon, halüsinasyonlar, koma ve nöbetleri içerebilir.

Keywords

• Bupropion, overdoses, seizures

Seizures After Overdoses of Bupropion Intake

Öz

Kaynakça

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