Pityriasis Rosea Associated with Pegylated Interferon Alfa and Ribavirin Treatment in a Patient with Chronic Hepatitis C

Abstract

Background: Pityriasis rosea is an acute inflamatory skin disease that the etiology is unknown but some viral agents like human herpes virus-6 and 7 and drugs are suspected. Case report: A-58-year-old man with chronic hepatitis C was being followed up in our hospital. Pegylated interferon (PEG-IFN) alfa-2b (100 µg per week) and ribavirin (1000 mg/day) was started. In the third month of this treatment, the patient was diagnosed with pityriasis rosea (PR), which was confirmed by skin biopsy. PEG-IFN alfa-2b treatment for chronic hepatitis C was maintained and no therapy was given for PR. The lesions spontaneously improved within 5 weeks. Conclusion: Interferon and ribavirin have several cutaneous side effects. Our case is the first case of PR, emerged in a patient with chronic hepatitis C while receiving PEG-IFN alfa 2b and ribavirin. Turkish Başlık: Kronik Hepatit C Tanılı Bir Hastada Pegile Interferon alfa ve Ribavirin Tedavisi ile İlişkili Pitriazis Rosea Anahtar Kelimeler: Pitriazis rosea, kronik hepatit C, ribavirin, pegile interferon alfa-2b Arka Plan: Pitriazis rosea (PR) etyolojisi bilinmeyen ancak insan herpes virüs-6 ve 7 gibi bazı viral ajanların şuçlandığı akut inflamatuar bir cilt hastalığıdır. Vaka sunumu: 58 yaşında erkek hasta kronik hepatit C tanısı ile hastanemizde takip edilmekteydi. Hastaya pegile interferon (PEG-IFN) alfa-2b (100 μg/hafta) ve ribavirin (1000 mg/gün) tedavisi başlandı. Hastaya tedavinin üçüncü ayında biyopsi ile doğrulanmış PR tanısı kondu. Kronik hepatit C nedeniyle almakta olduğu PEG-IFN alfa-2b tedavisine devam edildi ve PR için herhangi bir tedavi başlanmadı. Lezyonlar 5 hafta içinde kendiliğinden düzeldi. Sonuç: İnterferon ve ribavirin çeşitli kütanöz yan etkilere sahiptir. Bizim vakamız kronik hepatit C tanısı olup PEG-IFN alfa-2b ve ribavirin tedavisi alırken PR tanısı alan ilk hastadır.

Keywords

• Pityriasis rosea, chronic hepatitis C, ribavirin, pegylated interferon alfa-2b

Pityriasis Rosea Associated with Pegylated Interferon Alfa and Ribavirin Treatment in a Patient with Chronic Hepatitis C

Öz

Kaynakça

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