Öz
Primary central nervous system lymphoma constitutes only 1% of all intracranial tumors. Although survival time has increased by combined chemotherapy and radiotherapy, it still has a malign prognosis. A 62-year-old male patient presented with complaints of headache and forgetting. Cranial computerized tomography and magnetic resonance imaging demonstrated a mass in the left temporoparietal region extending to the posterior horn and trigone of the lateral ventricule. The case was diagnosed as lymphoma after stereotactic biopsy. There was a partial regression of symptoms after radiotherapy. The patient was lost due to local recurrence after 14 months. Turkish Başlık: Primer Santral Sinir Sistemi Lenfoması: Olgu Sunumu Anahtar Kelimeler: Beyin tümörleri; lenfoma Primer santral sinir sistemi lenfoması tüm intrakranyal tümörlerinin %1'ini oluşturmaktadır. Kombine kemoterapi ve radyoterapi sayesinde sağkalım süresi uzamış olsa da, hastalığın seyri halen maligndir. Altmış iki yaşında erkek hasta baş ağrısı ve unutkanlık yakınmalarıyla başvurdu. Yapılan kranyal bilgisayarlı tomografi ve manyetik rezonans incelemelerinde sol temporoparietal bölgede, lateral ventrikül trigonu ve arka boynuz boyunca yayılım gösteren kitle saptandı. Uygulanan stereotaktik biyopsi sonucunda olguya lenfoma tanısı konuldu. Radyoterapi sonrası semptomlarında kısmi bir iyileşme görülen hasta 14. ayda lokal nüks nedeniyle kaybedildi.
Anahtar Kelimeler
Kaynakça
- Ling SM, Roach M 3rd, Larson DA, Wara WM. Radiotherapy of primary central nervous system lymphoma in patients with and without human immunodeficiency virus. Ten years of treatment experience at the University of California San Francisco. Cancer 1994;73:2570-82.
- Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG. Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994. Neuro-oncol 1999;1:14-25.
- Eby NL, Grufferman S, Flannelly CM, Schold SC Jr, Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. Cancer 1988;62:2461-5.
- Russell DS, Rubinstein LJ, (editors). Nervous system involvement by lymphomas, histiocytoses and leukaemias. In: Pathology of tumours of the nervous system. 5th ed. Baltimore: Williams & Wilkins; 1989. p. 592-638.
- Shibata S. Sites of origin of primary intracerebral malignant lymphoma. Neurosurgery 1989;25:14-9.
- Hochberg FH, Miller DC. Primary central nervous system lymphoma. J Neurosurg 1988;68:835-53.
- Vaquero J, Martinez R, Rossi E, Lopez R. Primary cerebral lymphoma: the “ghost tumor”. Case report. J Neurosurg 1984;60:174-6.
- Nelson DF, Martz KL, Bonner H, Nelson JS, Newall J, Kerman HD, et al. Non-Hodgkin’s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 1992;23:9-17.
- Lachance DH, Gockerman J, Halperin E, et al. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for primary central nervous sys- tem lymphoma (PCNSL): Short-duration response, multi-focal intracerebral recurrence preceding radio- therapy. Neurology 1992;42(Suppl 3):343.
Öz
Primer santral sinir sistemi lenfoması tüm intrakranyal tümörlerinin %1'ini oluşturmaktadır. Kombine kemoterapi ve radyoterapi sayesinde sağkalım süresi uzamış olsa da, hastalığın seyri halen maligndir. Altmış iki yaşında erkek hasta baş ağrısı ve unutkanlık yakınmalarıyla başvurdu. Yapılan kranyal bilgisayarlı tomografi ve manyetik rezonans incelemelerinde sol temporoparietal bölgede, lateral ventrikül trigonu ve arka boynuz boyunca yayılım gösteren kitle saptandı. Uygulanan stereotaktik biyopsi sonucunda olguya lenfoma tanısı konuldu. Radyoterapi sonrası semptomlarında kısmi bir iyileşme görülen hasta 14. ayda lokal nüks nedeniyle kaybedildi.
Anahtar Kelimeler
Kaynakça
- Ling SM, Roach M 3rd, Larson DA, Wara WM. Radiotherapy of primary central nervous system lymphoma in patients with and without human immunodeficiency virus. Ten years of treatment experience at the University of California San Francisco. Cancer 1994;73:2570-82.
- Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG. Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994. Neuro-oncol 1999;1:14-25.
- Eby NL, Grufferman S, Flannelly CM, Schold SC Jr, Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. Cancer 1988;62:2461-5.
- Russell DS, Rubinstein LJ, (editors). Nervous system involvement by lymphomas, histiocytoses and leukaemias. In: Pathology of tumours of the nervous system. 5th ed. Baltimore: Williams & Wilkins; 1989. p. 592-638.
- Shibata S. Sites of origin of primary intracerebral malignant lymphoma. Neurosurgery 1989;25:14-9.
- Hochberg FH, Miller DC. Primary central nervous system lymphoma. J Neurosurg 1988;68:835-53.
- Vaquero J, Martinez R, Rossi E, Lopez R. Primary cerebral lymphoma: the “ghost tumor”. Case report. J Neurosurg 1984;60:174-6.
- Nelson DF, Martz KL, Bonner H, Nelson JS, Newall J, Kerman HD, et al. Non-Hodgkin’s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 1992;23:9-17.
- Lachance DH, Gockerman J, Halperin E, et al. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for primary central nervous sys- tem lymphoma (PCNSL): Short-duration response, multi-focal intracerebral recurrence preceding radio- therapy. Neurology 1992;42(Suppl 3):343.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Şubat 2006 |
| Yayımlandığı Sayı | Yıl 2006 Cilt: 2006 Sayı: 2 |