BibTex RIS Kaynak Göster
Yıl 2015, Cilt: 32 Sayı: 3, 266 - 272, 01.07.2015

Öz

Kaynakça

  • 1. Hepatitis C. Geneva: World Health Organization, 2011. (http:// www.who.int/vaccine_research/diseases/hepatitis_c/en/.) 2. World Health Organization. Global surveillance and control of hepatitis C: report of a WHO consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Hepat 1999;6:35-47. [CrossRef]
  • 3. Thomas MB, Jaffe D, Choti MM, Belghiti J, Curley S, Fong Y, et al. Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Trials Planning Meeting. J Clin Oncol 2010;28:3994-4005. [CrossRef]
  • 4. Aygen B. Hepatitis C. Turkiye Klinikleri J Int Med Sci 2006;2:21-33. 5. Bozkurt I, Aygen B, Gökahmetoglu S, Yildiz O. Hepatitis C and occult hepatitis C infection among hemodialysis patients from Central Anatolia. J Pure Appl Microbiol 2014:8:435-40.
  • 6. Aygen B, Deniz K, Akhan S, Çelen MK, Yıldız O, Ayaz C, et al. Frequency and epidemiologic characteristics of hepatitis C virus infection in patients receiving hemodialysis in our region. Klimik Journal 2012;25:19-23. [CrossRef]
  • 7. Gökahmetoğlu S, Bozdayı M, Özbakır Ö, Aygen B, Özbal Y, Soyuer I, et al. Hepatitis C virus genotypes detected in Erciyes University. Journal of Turkish Society of Microbiology 2007;37:35-8.
  • 8. Gökahmetoğlu S, Atalay MA, Kılınç A. Determination of the hepatitis C virus genotypes with “pyrosequencing” method. Erciyes Medical Journal 2011;33:99-102.
  • 9. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL Jr, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-82. [CrossRef]
  • 10. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958-65. [CrossRef]
  • 11. Kamal SM, Nasser IA. Hepatitis C genotype 4: what we know and what we don’t yet know. Hepatology 2008;47:1371-83. [CrossRef]
  • 12. McHutchison JG, Everson GT, Gordon SC, Jacobson IM, Sulkowski M, Kauffman R, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009;360:1827-38. [CrossRef]
  • 13. McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, et al; PROVE3 Study Team. Telaprevir for previously treated chronic HCV infection. N Engl J Med 2010; 362:1292-303. [CrossRef]
  • 14. Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, et al; ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011;364:2405-16. [CrossRef]
  • 15. Sherman KE, Flamm SL, Afdhal NH, Nelson DR, Sulkowski MS, Everson GT, et al; ILLUMINATE Study Team. Responseguided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011;365:1014-24. [CrossRef]
  • 16. Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, et al; REALIZE Study Team. Telaprevir for retreatment of HCV infection. N Engl J Med 2011;364:2417-28. [CrossRef]
  • 17. Benhamou Y, Moussalli J, Ratziu V, Lebray P, De Backer K, De Meyer S, et al. Telaprevir activity in treatment-naive patients infected hepatitis C virus genotype 4: a randomized trial. J Infect Dis 2013;208:1000-7. [CrossRef]
  • 18. Ishak K, Baptisa A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-9. [CrossRef]
  • 19. Omata M, Kanda T, Yu ML, Yokosuka O, Lim SG, Jafri W, et al. APASL consensus statements and management algorithms for hepatitis C virus infection. Hepatol Int 2012;6:409-35. [CrossRef]
  • 20. Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335-74. [CrossRef]
  • 21. Sung H, Chang M, Saab S. Management of hepatitis C antiviral therapy adverse effects. Curr Hepat Rep 2011;10:33-40. [CrossRef] 22. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2011;55:245-64. [CrossRef]
  • 23. El Awady MK, Bader El Din NG, Tabll A, El Hosary Y, Abdel Aziz AO, El Khayat H, et al. IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients. World J Gastroenterol 2013;19:290-8. [CrossRef]
  • 24. Muir AJ, Poordad FF, McHutchison JG, Shiffman ML, Berg T, Ferenci P, et al. Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response. Hepatology 2011;54:1538-46. [CrossRef]
  • 25. Poynard T, Colombo M, Bruix J, Schiff E, Terg R, Flamm S, et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 2009;136:1618-28. [CrossRef]
  • 26. Shiffman ML, Di Bisceglie AM, Lindsay KL, Morishima C, Wright EC, Everson GT, et al; Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial Group. Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology 2004;126:1015-23. [CrossRef]
  • 27. Ghany MG, Nelson DR, Strader DB, Thomas DL, Seeff LB. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011;54:1433-44. [CrossRef]

Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey

Yıl 2015, Cilt: 32 Sayı: 3, 266 - 272, 01.07.2015

Öz

Background: The use of pegylated interferon alpha and ribavirin (PegIFN/RBV) for the retreatment of chronic hepatitis C virus (HCV) infection without a sustained virological response (SVR) prior to PegIFN/RBV treatment has resulted in low success rates. Aims: To investigate the efficacy and safety of telaprevir (TVR) in combination with PegIFN/RBV in patients infected with HCV genotypes 1 and 4 who were previously treated with PegIFN/RBV and failed to achieve SVR. Study Design: Multi-center, retrospective, cross-sectional study. Methods: The study included 111 patients: 80 prior relapsers, 25 prior null responders, and six prior partial responders to PegIFN/RBV treatment. The patients were given TVR/PegIFN/RBV for 12 weeks, followed by a 12-week PegIFN/RBV treatment; virological response results were assessed at weeks 4, 12, and 24. Treatment was discontinued in patients with HCV RNA >1000 IU/mL at week 4 or with negative RNA results at week 4 but >1000 IU/mL at week 12. Rapid virological response (RVR), early virological response (EVR), extended rapid virological response (eRVR), and virological response at 24th week of treatment were evaluated. The side effects of combination therapy and the rates of treatment discontinuation were investigated. Results: The mean age of the patients was 56.02±9.96 years and 45.9% were male. Ninety-one percent of the patients were infected with viral genotype 1, 69.6% with the interleukin (IL) 28B genotype CT and 20.2% were cirrhotic. The RVR rate was 86.3% in prior relapsers, 56% in prior null responders, and 50% in prior partial responders (p=0.002). EVR rates in those groups were 91.3%, 56%, and 83.3%, respectively (p<0.001). eRVR rates were 83.8% in prior relapsers, 48% in prior null responders, and 50% in prior partial responders (<0.001). The virological response at the 24th week of treatment was found to be the highest in prior relapsers (88.8%); it was 56% in prior null responders and 66.7% in prior partial responders (p<0.001). Common side effects were fatigue, headache, anorexia, malaise, anemia, pruritus, dry skin, rash, dyspepsia, nausea, pyrexia, stomachache, and anorectal discomfort. All treatments were discontinued due to side effects in 9.9% of patients. Conclusion: High virological response rates were obtained with TVR/PegIFN/RBV treatment. Although side effects were frequently observed, the discontinuation rate of combination therapy was low.

Kaynakça

  • 1. Hepatitis C. Geneva: World Health Organization, 2011. (http:// www.who.int/vaccine_research/diseases/hepatitis_c/en/.) 2. World Health Organization. Global surveillance and control of hepatitis C: report of a WHO consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Hepat 1999;6:35-47. [CrossRef]
  • 3. Thomas MB, Jaffe D, Choti MM, Belghiti J, Curley S, Fong Y, et al. Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Trials Planning Meeting. J Clin Oncol 2010;28:3994-4005. [CrossRef]
  • 4. Aygen B. Hepatitis C. Turkiye Klinikleri J Int Med Sci 2006;2:21-33. 5. Bozkurt I, Aygen B, Gökahmetoglu S, Yildiz O. Hepatitis C and occult hepatitis C infection among hemodialysis patients from Central Anatolia. J Pure Appl Microbiol 2014:8:435-40.
  • 6. Aygen B, Deniz K, Akhan S, Çelen MK, Yıldız O, Ayaz C, et al. Frequency and epidemiologic characteristics of hepatitis C virus infection in patients receiving hemodialysis in our region. Klimik Journal 2012;25:19-23. [CrossRef]
  • 7. Gökahmetoğlu S, Bozdayı M, Özbakır Ö, Aygen B, Özbal Y, Soyuer I, et al. Hepatitis C virus genotypes detected in Erciyes University. Journal of Turkish Society of Microbiology 2007;37:35-8.
  • 8. Gökahmetoğlu S, Atalay MA, Kılınç A. Determination of the hepatitis C virus genotypes with “pyrosequencing” method. Erciyes Medical Journal 2011;33:99-102.
  • 9. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL Jr, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-82. [CrossRef]
  • 10. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958-65. [CrossRef]
  • 11. Kamal SM, Nasser IA. Hepatitis C genotype 4: what we know and what we don’t yet know. Hepatology 2008;47:1371-83. [CrossRef]
  • 12. McHutchison JG, Everson GT, Gordon SC, Jacobson IM, Sulkowski M, Kauffman R, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009;360:1827-38. [CrossRef]
  • 13. McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, et al; PROVE3 Study Team. Telaprevir for previously treated chronic HCV infection. N Engl J Med 2010; 362:1292-303. [CrossRef]
  • 14. Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, et al; ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011;364:2405-16. [CrossRef]
  • 15. Sherman KE, Flamm SL, Afdhal NH, Nelson DR, Sulkowski MS, Everson GT, et al; ILLUMINATE Study Team. Responseguided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011;365:1014-24. [CrossRef]
  • 16. Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, et al; REALIZE Study Team. Telaprevir for retreatment of HCV infection. N Engl J Med 2011;364:2417-28. [CrossRef]
  • 17. Benhamou Y, Moussalli J, Ratziu V, Lebray P, De Backer K, De Meyer S, et al. Telaprevir activity in treatment-naive patients infected hepatitis C virus genotype 4: a randomized trial. J Infect Dis 2013;208:1000-7. [CrossRef]
  • 18. Ishak K, Baptisa A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-9. [CrossRef]
  • 19. Omata M, Kanda T, Yu ML, Yokosuka O, Lim SG, Jafri W, et al. APASL consensus statements and management algorithms for hepatitis C virus infection. Hepatol Int 2012;6:409-35. [CrossRef]
  • 20. Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335-74. [CrossRef]
  • 21. Sung H, Chang M, Saab S. Management of hepatitis C antiviral therapy adverse effects. Curr Hepat Rep 2011;10:33-40. [CrossRef] 22. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2011;55:245-64. [CrossRef]
  • 23. El Awady MK, Bader El Din NG, Tabll A, El Hosary Y, Abdel Aziz AO, El Khayat H, et al. IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients. World J Gastroenterol 2013;19:290-8. [CrossRef]
  • 24. Muir AJ, Poordad FF, McHutchison JG, Shiffman ML, Berg T, Ferenci P, et al. Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response. Hepatology 2011;54:1538-46. [CrossRef]
  • 25. Poynard T, Colombo M, Bruix J, Schiff E, Terg R, Flamm S, et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 2009;136:1618-28. [CrossRef]
  • 26. Shiffman ML, Di Bisceglie AM, Lindsay KL, Morishima C, Wright EC, Everson GT, et al; Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial Group. Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology 2004;126:1015-23. [CrossRef]
  • 27. Ghany MG, Nelson DR, Strader DB, Thomas DL, Seeff LB. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011;54:1433-44. [CrossRef]
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA89KN65HZ
Bölüm Araştırma Makalesi
Yazarlar

Orhan Yıldız Bu kişi benim

Sıla Akhan Bu kişi benim

Elif Sargın Altınok Bu kişi benim

Mustafa Kemal Çelen Bu kişi benim

Onur Ural Bu kişi benim

Nazlım Aktuğ Demir Bu kişi benim

Şua Sümer Bu kişi benim

Süda Tekin Koruk Bu kişi benim

Şükran Köse Bu kişi benim

Fatime Korkmaz Bu kişi benim

Ziya Kuruüzüm Bu kişi benim

Nazan Tuna Bu kişi benim

Serpil Taheri Bu kişi benim

Murat Sayan Bu kişi benim

Yayımlanma Tarihi 1 Temmuz 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 32 Sayı: 3

Kaynak Göster

APA Yıldız, O., Akhan, S., Altınok, E. S., Çelen, M. K., vd. (2015). Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey. Balkan Medical Journal, 32(3), 266-272.
AMA Yıldız O, Akhan S, Altınok ES, Çelen MK, Ural O, Demir NA, Sümer Ş, Koruk ST, Köse Ş, Korkmaz F, Kuruüzüm Z, Tuna N, Taheri S, Sayan M. Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey. Balkan Medical Journal. Temmuz 2015;32(3):266-272.
Chicago Yıldız, Orhan, Sıla Akhan, Elif Sargın Altınok, Mustafa Kemal Çelen, Onur Ural, Nazlım Aktuğ Demir, Şua Sümer, Süda Tekin Koruk, Şükran Köse, Fatime Korkmaz, Ziya Kuruüzüm, Nazan Tuna, Serpil Taheri, ve Murat Sayan. “Retreatment of Chronic Hepatitis C Infection With Telaprevir: Preliminary Results in Turkey”. Balkan Medical Journal 32, sy. 3 (Temmuz 2015): 266-72.
EndNote Yıldız O, Akhan S, Altınok ES, Çelen MK, Ural O, Demir NA, Sümer Ş, Koruk ST, Köse Ş, Korkmaz F, Kuruüzüm Z, Tuna N, Taheri S, Sayan M (01 Temmuz 2015) Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey. Balkan Medical Journal 32 3 266–272.
IEEE O. Yıldız, “Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey”, Balkan Medical Journal, c. 32, sy. 3, ss. 266–272, 2015.
ISNAD Yıldız, Orhan vd. “Retreatment of Chronic Hepatitis C Infection With Telaprevir: Preliminary Results in Turkey”. Balkan Medical Journal 32/3 (Temmuz 2015), 266-272.
JAMA Yıldız O, Akhan S, Altınok ES, Çelen MK, Ural O, Demir NA, Sümer Ş, Koruk ST, Köse Ş, Korkmaz F, Kuruüzüm Z, Tuna N, Taheri S, Sayan M. Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey. Balkan Medical Journal. 2015;32:266–272.
MLA Yıldız, Orhan vd. “Retreatment of Chronic Hepatitis C Infection With Telaprevir: Preliminary Results in Turkey”. Balkan Medical Journal, c. 32, sy. 3, 2015, ss. 266-72.
Vancouver Yıldız O, Akhan S, Altınok ES, Çelen MK, Ural O, Demir NA, Sümer Ş, Koruk ST, Köse Ş, Korkmaz F, Kuruüzüm Z, Tuna N, Taheri S, Sayan M. Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey. Balkan Medical Journal. 2015;32(3):266-72.