Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study

Yıl 2016, Cilt: 33 Sayı: 1, 18 - 26, 01.01.2016

Öz

Background: Before the introduction of direct-acting antivirals in the treatment of chronic hepatitis C patients, the combination of peginterferon alpha and ribavirin was the standard therapy. Observational studies that investigated sustained virological response (SVR) rates by these drugs yielded different outcomes. Aims: The goal of the study was to demonstrate real life data concerning SVR rate achieved by peginterferon alpha plus ribavirin in patients who were treatment-naïve. Study Design: A multicenter, retrospective observational study. Methods: The study was conducted retrospectively on 1214 treatment naïve-patients, being treated with peginterferon alpha-2a or 2b plus ribavirin in respect of the current guidelines between 2005 and 2013. The patients’ data were collected from 22 centers via a standard form, which has been prepared for this study. The data included demographic and clinical characteristics (gender, age, body weight, initial Hepatitis C virus RNA (HCV RNA) level, disease staging) as well as course of treatment (duration of treatment, outcomes, discontinuations and adverse events). Renal insufficiency, decompensated liver disease, history of transplantation, immunosuppressive therapy or autoimmune liver disease were exclusion criteria for the study. Treatment efficacy was assessed according to the patient’s demographic characteristics, baseline viral load, genotype, and fibrosis scores. Results: The mean age of the patients was 50.74 (±0.64) years. Most of them were infected with genotype 1 (91.8%). SVR was achieved in 761 (62.7%) patients. SVR rate was 59.1% in genotype 1, 89.4% in genotype 2, 93.8% in genotype 3, and 33.3% in genotype 4 patients. Patients with lower viral load yielded higher SVR (65.8% vs. 58.4%, p=0.09). SVR rates according to histologic severity were found to be 69.3%, 66.3%, 59.9%, 47.3%, and 45.5% in patients with fibrosis stage 0, 1, 2, 3 and 4, respectively. The predictors of SVR were male gender, genotype 2/3, age less than 45 years, low fibrosis stage, low baseline viral load and presence of early virological response. SVR rates to each peginterferon were found to be similar in genotype 1/4 although SVR rates were found to be higher for peginterferon alpha-2b in patients with genotype 2/3. The number of patients who failed to complete treatment due to adverse effects was 33 (2.7%). The number of patients failed to complete treatment due to adverse effects was 33 (2.7%). Conclusion: Our findings showed that the rate of SVR to dual therapy was higher in treatment-naïve Turkish patients than that reported in randomized controlled trials. Also peginterferon alpha-2a and alpha-2b were found to be similar in terms of SVR in genotype 1 patients.

Anahtar Kelimeler

Hepatitis C, peginterferon alpha-2a, peginterferon alpha-2b, ribavirin, therapy

Kaynakça

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Toplam 29 adet kaynakça vardır.

Ayrıntılar

Diğer ID	JA97TM97VT
Bölüm	Araştırma Makalesi
Yazarlar	Yunus Gürbüz Bu kişi benim Emin Ediz Tütüncü Bu kişi benim Necla Eren Tülek Bu kişi benim Sami Kınıklı Bu kişi benim Günay Tuncer Bu kişi benim Cemal Bulut Bu kişi benim Süda Tekin Koruk Bu kişi benim Bilgehan Aygen Bu kişi benim Neşe Demirtürk Bu kişi benim Ali Kaya Bu kişi benim Taner Yıldırmak Bu kişi benim Kaya Süer Bu kişi benim Fatime Korkmaz Bu kişi benim Onur Ural Bu kişi benim Sıla Akhan Bu kişi benim Aynur Aynıoğlu Bu kişi benim Elif Sargın Altunok Bu kişi benim Özgür Günal Bu kişi benim Nazan Tuna Bu kişi benim Şükran Köse Bu kişi benim İbak Gönen Bu kişi benim Bahar Örmen Bu kişi benim Nesrin Türker Bu kişi benim Neşe Saltoğlu Bu kişi benim Ayşe Batırel Bu kişi benim Fatma Sırmatel Bu kişi benim Asım Ulçay Bu kişi benim Ergenekon Karagöz Bu kişi benim Derviş Tosun Bu kişi benim Alper Şener Bu kişi benim
Yayımlanma Tarihi	1 Ocak 2016
Yayımlandığı Sayı	Yıl 2016 Cilt: 33 Sayı: 1

Kaynak Göster

APA	Gürbüz, Y., Tütüncü, E. E., Tülek, N. E., Kınıklı, S., vd. (2016). Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal, 33(1), 18-26.
AMA	Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal. Ocak 2016;33(1):18-26.
Chicago	Gürbüz, Yunus, Emin Ediz Tütüncü, Necla Eren Tülek, Sami Kınıklı, Günay Tuncer, Cemal Bulut, Süda Tekin Koruk, Bilgehan Aygen, Neşe Demirtürk, Ali Kaya, Taner Yıldırmak, Kaya Süer, Fatime Korkmaz, Onur Ural, Sıla Akhan, Aynur Aynıoğlu, Elif Sargın Altunok, Özgür Günal, Nazan Tuna, Şükran Köse, İbak Gönen, Bahar Örmen, Nesrin Türker, Neşe Saltoğlu, Ayşe Batırel, Fatma Sırmatel, Asım Ulçay, Ergenekon Karagöz, Derviş Tosun, ve Alper Şener. “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients With HCV Infection: A Multicenter, Retrospective Study”. Balkan Medical Journal 33, sy. 1 (Ocak 2016): 18-26.
EndNote	Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A (01 Ocak 2016) Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal 33 1 18–26.
IEEE	Y. Gürbüz, “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study”, Balkan Medical Journal, c. 33, sy. 1, ss. 18–26, 2016.
ISNAD	Gürbüz, Yunus vd. “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients With HCV Infection: A Multicenter, Retrospective Study”. Balkan Medical Journal 33/1 (Ocak 2016), 18-26.
JAMA	Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal. 2016;33:18–26.
MLA	Gürbüz, Yunus vd. “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients With HCV Infection: A Multicenter, Retrospective Study”. Balkan Medical Journal, c. 33, sy. 1, 2016, ss. 18-26.
Vancouver	Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal. 2016;33(1):18-26.

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