BibTex RIS Kaynak Göster
Yıl 2016, Cilt: 33 Sayı: 1, 18 - 26, 01.01.2016

Öz

Kaynakça

  • 1. Alter MJ. The epidemiology of acute and chronic hepatitis C. Clin Liver Dis 1997;1:559-68, vi-vii. [CrossRef]
  • 2. Balik I, Tosun S, Tabak F, Saltoglu N, Ormeci N, Sencan I, et al. Investigation of viral hepatitis epidemiology by a touring/travelling team [Turkish Viral Hepatitis Society Bus Project]. APASL Brisbane: Hepatology International; 2014. p. 1-405.
  • 3. Dayan S, Tekin A, Tekin R, Dal T, Hosoglu S, Yazgan UC, et al. HBsAg, anti-HCV, anti-HIV 1/2 and syphilis seroprevalence in healthy volunteer blood donors in southeastern Anatolia. J Infect Dev Ctries 2013;7:665-9. [CrossRef]
  • 4. Freeman AJ, Dore GJ, Law MG, Thorpe M, Von Overbeck J, Lloyd AR, et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology 2001;34:809-16. [CrossRef]
  • 5. Sangiovanni A, Del Ninno E, Fasani P, De Fazio C, Ronchi G, Romeo R, et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004;126:1005-14. [CrossRef]
  • 6. Veldt BJ, Heathcote EJ, Wedemeyer H, Reichen J, Hofmann WP, Zeuzem S, et al. Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 2007;147:677-84. [CrossRef]
  • 7. Miyake Y, Iwasaki Y, Yamamoto K. Meta-analysis: reduced incidence of hepatocellular carcinoma in patients not responding to interferon therapy of chronic hepatitis C. Int J Cancer 2010;127:989-96.
  • 8. Strader DB, Wright T, Thomas DL, Seeff LB; American Association for the Study of Liver D. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004;39:1147-71. [CrossRef]
  • 9. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958-65. [CrossRef]
  • 10. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr., et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-82. [CrossRef]
  • 11. Buruk CK, Bayramoglu G, Reis A, Kaklikkaya N, Tosun I, Aydin F. Determination of hepatitis C virus genotypes among hepatitis C patients in Eastern Black Sea Region, Turkey. Mikrobiyol Bul 2013;47:650-7. [CrossRef]
  • 12. Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, et al. Genetic variation in IL28B predicts hepatitis C treatmentinduced viral clearance. Nature 2009;461:399-401. [CrossRef]
  • 13. Hadziyannis SJ, Sette H Jr, Morgan TR, Balan V, Diago M, Marcellin P, et al; PEGASYS International Study Group. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Int Med 2004;140:346-55. [CrossRef]
  • 14. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996;24:289-93. [CrossRef]
  • 15. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology 1994;20:15- 20. [CrossRef]
  • 16. Ozer B, Serin E, Yilmaz U, Gumurdulu Y, Saygili OB, Kayaselcuk F, et al. Clinicopathologic features and risk factors for hepatocellular carcinoma: results from a single center in southern Turkey. Turk J Gastroenterol 2003;14:85-90.
  • 17. Alacacioglu A, Somali I, Simsek I, Astarcioglu I, Ozkan M, Camci C, et al. Epidemiology and survival of hepatocellular carcinoma in Turkey: outcome of multicenter study. Jpn J Clin Oncol 2008;38:683-8. [CrossRef]
  • 18. Uzunalimoglu O, Yurdaydin C, Cetinkaya H, Bozkaya H, Sahin T, Colakoglu S, et al. Risk factors for hepatocellular carcinoma in Turkey. Dig Dis Sci 2001;46:1022-8. [CrossRef]
  • 19. Swain MG, Lai MY, Shiffman ML, Cooksley WG, Zeuzem S, Dieterich DT, et al. A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin. Gastroenterology 2010;139:1593-601. [CrossRef]
  • 20. Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010;139:120-9.e18. [CrossRef]
  • 21. Park SH, Park CK, Lee JW, Kim YS, Jeong SH, Kim YS, et al. Efficacy and tolerability of peginterferon alpha plus ribavirin in the routine daily treatment of chronic hepatitis C patients in Korea: a multi-center, retrospective observational study. Gut Liver 2012;6:98-106. [CrossRef]
  • 22. Ridruejo E, Adrover R, Cocozzella D, Fernandez N, Reggiardo MV. Efficacy, tolerability and safety in the treatment of chronic hepatitis C with combination of PEG-Interferon - Ribavirin in daily practice. Ann Hepatol 2010;9:46-51.
  • 23. Borroni G, Andreoletti M, Casiraghi MA, Ceriani R, Guerzoni P, Omazzi B, et al. Effectiveness of pegylated interferon/ribavirin combination in ‘real world’ patients with chronic hepatitis C virus infection. Aliment Pharmacol Ther 2008;27:790-7. [CrossRef]
  • 24. Bourliere M, Ouzan D, Rosenheim M, Doffoel M, Marcellin P, Pawlotsky JM, et al. Pegylated interferon-alpha2a plus ribavirin for chronic hepatitis C in a real-life setting: the Hepatys French cohort (2003-2007). Antivir Ther 2012;17:101-10. [CrossRef]
  • 25. Yenice N, Mehtap O, Gumrah M, Arican N. The efficacy of pegylated interferon alpha 2a or 2b plus ribavirin in chronic hepatitis C patients. Turk J Gastroenterol 2006;17:94-8.
  • 26. Dogan UB, Akin MS, Yalaki S. Sustained virological response based on the week 4 response in hepatitis C virus genotype 1 patients treated with peginterferons alpha-2a and alpha-2b, plus ribavirin. Eur J Gastroenterol Hepatol 2013;25:1317-20. [CrossRef]
  • 27. Kau A, Vermehren J, Sarrazin C. Treatment predictors of a sustained virologic response in hepatitis B and C. J Hepatol 2008;49:634-51. [CrossRef]
  • 28. D’Souza R, Sabin CA, Foster GR. Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy. Am J Gastroenterol 2005;100:1509-15. [CrossRef]
  • 29. Cua IH, Hui JM, Kench JG, George J. Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C. Hepatology 2008;48:723-31. [CrossRef

Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study

Yıl 2016, Cilt: 33 Sayı: 1, 18 - 26, 01.01.2016

Öz

Background: Before the introduction of direct-acting antivirals in the treatment of chronic hepatitis C patients, the combination of peginterferon alpha and ribavirin was the standard therapy. Observational studies that investigated sustained virological response (SVR) rates by these drugs yielded different outcomes. Aims: The goal of the study was to demonstrate real life data concerning SVR rate achieved by peginterferon alpha plus ribavirin in patients who were treatment-naïve. Study Design: A multicenter, retrospective observational study. Methods: The study was conducted retrospectively on 1214 treatment naïve-patients, being treated with peginterferon alpha-2a or 2b plus ribavirin in respect of the current guidelines between 2005 and 2013. The patients’ data were collected from 22 centers via a standard form, which has been prepared for this study. The data included demographic and clinical characteristics (gender, age, body weight, initial Hepatitis C virus RNA (HCV RNA) level, disease staging) as well as course of treatment (duration of treatment, outcomes, discontinuations and adverse events). Renal insufficiency, decompensated liver disease, history of transplantation, immunosuppressive therapy or autoimmune liver disease were exclusion criteria for the study. Treatment efficacy was assessed according to the patient’s demographic characteristics, baseline viral load, genotype, and fibrosis scores. Results: The mean age of the patients was 50.74 (±0.64) years. Most of them were infected with genotype 1 (91.8%). SVR was achieved in 761 (62.7%) patients. SVR rate was 59.1% in genotype 1, 89.4% in genotype 2, 93.8% in genotype 3, and 33.3% in genotype 4 patients. Patients with lower viral load yielded higher SVR (65.8% vs. 58.4%, p=0.09). SVR rates according to histologic severity were found to be 69.3%, 66.3%, 59.9%, 47.3%, and 45.5% in patients with fibrosis stage 0, 1, 2, 3 and 4, respectively. The predictors of SVR were male gender, genotype 2/3, age less than 45 years, low fibrosis stage, low baseline viral load and presence of early virological response. SVR rates to each peginterferon were found to be similar in genotype 1/4 although SVR rates were found to be higher for peginterferon alpha-2b in patients with genotype 2/3. The number of patients who failed to complete treatment due to adverse effects was 33 (2.7%). The number of patients failed to complete treatment due to adverse effects was 33 (2.7%). Conclusion: Our findings showed that the rate of SVR to dual therapy was higher in treatment-naïve Turkish patients than that reported in randomized controlled trials. Also peginterferon alpha-2a and alpha-2b were found to be similar in terms of SVR in genotype 1 patients.

Kaynakça

  • 1. Alter MJ. The epidemiology of acute and chronic hepatitis C. Clin Liver Dis 1997;1:559-68, vi-vii. [CrossRef]
  • 2. Balik I, Tosun S, Tabak F, Saltoglu N, Ormeci N, Sencan I, et al. Investigation of viral hepatitis epidemiology by a touring/travelling team [Turkish Viral Hepatitis Society Bus Project]. APASL Brisbane: Hepatology International; 2014. p. 1-405.
  • 3. Dayan S, Tekin A, Tekin R, Dal T, Hosoglu S, Yazgan UC, et al. HBsAg, anti-HCV, anti-HIV 1/2 and syphilis seroprevalence in healthy volunteer blood donors in southeastern Anatolia. J Infect Dev Ctries 2013;7:665-9. [CrossRef]
  • 4. Freeman AJ, Dore GJ, Law MG, Thorpe M, Von Overbeck J, Lloyd AR, et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology 2001;34:809-16. [CrossRef]
  • 5. Sangiovanni A, Del Ninno E, Fasani P, De Fazio C, Ronchi G, Romeo R, et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004;126:1005-14. [CrossRef]
  • 6. Veldt BJ, Heathcote EJ, Wedemeyer H, Reichen J, Hofmann WP, Zeuzem S, et al. Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 2007;147:677-84. [CrossRef]
  • 7. Miyake Y, Iwasaki Y, Yamamoto K. Meta-analysis: reduced incidence of hepatocellular carcinoma in patients not responding to interferon therapy of chronic hepatitis C. Int J Cancer 2010;127:989-96.
  • 8. Strader DB, Wright T, Thomas DL, Seeff LB; American Association for the Study of Liver D. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004;39:1147-71. [CrossRef]
  • 9. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958-65. [CrossRef]
  • 10. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr., et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-82. [CrossRef]
  • 11. Buruk CK, Bayramoglu G, Reis A, Kaklikkaya N, Tosun I, Aydin F. Determination of hepatitis C virus genotypes among hepatitis C patients in Eastern Black Sea Region, Turkey. Mikrobiyol Bul 2013;47:650-7. [CrossRef]
  • 12. Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, et al. Genetic variation in IL28B predicts hepatitis C treatmentinduced viral clearance. Nature 2009;461:399-401. [CrossRef]
  • 13. Hadziyannis SJ, Sette H Jr, Morgan TR, Balan V, Diago M, Marcellin P, et al; PEGASYS International Study Group. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Int Med 2004;140:346-55. [CrossRef]
  • 14. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996;24:289-93. [CrossRef]
  • 15. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology 1994;20:15- 20. [CrossRef]
  • 16. Ozer B, Serin E, Yilmaz U, Gumurdulu Y, Saygili OB, Kayaselcuk F, et al. Clinicopathologic features and risk factors for hepatocellular carcinoma: results from a single center in southern Turkey. Turk J Gastroenterol 2003;14:85-90.
  • 17. Alacacioglu A, Somali I, Simsek I, Astarcioglu I, Ozkan M, Camci C, et al. Epidemiology and survival of hepatocellular carcinoma in Turkey: outcome of multicenter study. Jpn J Clin Oncol 2008;38:683-8. [CrossRef]
  • 18. Uzunalimoglu O, Yurdaydin C, Cetinkaya H, Bozkaya H, Sahin T, Colakoglu S, et al. Risk factors for hepatocellular carcinoma in Turkey. Dig Dis Sci 2001;46:1022-8. [CrossRef]
  • 19. Swain MG, Lai MY, Shiffman ML, Cooksley WG, Zeuzem S, Dieterich DT, et al. A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin. Gastroenterology 2010;139:1593-601. [CrossRef]
  • 20. Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010;139:120-9.e18. [CrossRef]
  • 21. Park SH, Park CK, Lee JW, Kim YS, Jeong SH, Kim YS, et al. Efficacy and tolerability of peginterferon alpha plus ribavirin in the routine daily treatment of chronic hepatitis C patients in Korea: a multi-center, retrospective observational study. Gut Liver 2012;6:98-106. [CrossRef]
  • 22. Ridruejo E, Adrover R, Cocozzella D, Fernandez N, Reggiardo MV. Efficacy, tolerability and safety in the treatment of chronic hepatitis C with combination of PEG-Interferon - Ribavirin in daily practice. Ann Hepatol 2010;9:46-51.
  • 23. Borroni G, Andreoletti M, Casiraghi MA, Ceriani R, Guerzoni P, Omazzi B, et al. Effectiveness of pegylated interferon/ribavirin combination in ‘real world’ patients with chronic hepatitis C virus infection. Aliment Pharmacol Ther 2008;27:790-7. [CrossRef]
  • 24. Bourliere M, Ouzan D, Rosenheim M, Doffoel M, Marcellin P, Pawlotsky JM, et al. Pegylated interferon-alpha2a plus ribavirin for chronic hepatitis C in a real-life setting: the Hepatys French cohort (2003-2007). Antivir Ther 2012;17:101-10. [CrossRef]
  • 25. Yenice N, Mehtap O, Gumrah M, Arican N. The efficacy of pegylated interferon alpha 2a or 2b plus ribavirin in chronic hepatitis C patients. Turk J Gastroenterol 2006;17:94-8.
  • 26. Dogan UB, Akin MS, Yalaki S. Sustained virological response based on the week 4 response in hepatitis C virus genotype 1 patients treated with peginterferons alpha-2a and alpha-2b, plus ribavirin. Eur J Gastroenterol Hepatol 2013;25:1317-20. [CrossRef]
  • 27. Kau A, Vermehren J, Sarrazin C. Treatment predictors of a sustained virologic response in hepatitis B and C. J Hepatol 2008;49:634-51. [CrossRef]
  • 28. D’Souza R, Sabin CA, Foster GR. Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy. Am J Gastroenterol 2005;100:1509-15. [CrossRef]
  • 29. Cua IH, Hui JM, Kench JG, George J. Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C. Hepatology 2008;48:723-31. [CrossRef
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA97TM97VT
Bölüm Araştırma Makalesi
Yazarlar

Yunus Gürbüz Bu kişi benim

Emin Ediz Tütüncü Bu kişi benim

Necla Eren Tülek Bu kişi benim

Sami Kınıklı Bu kişi benim

Günay Tuncer Bu kişi benim

Cemal Bulut Bu kişi benim

Süda Tekin Koruk Bu kişi benim

Bilgehan Aygen Bu kişi benim

Neşe Demirtürk Bu kişi benim

Ali Kaya Bu kişi benim

Taner Yıldırmak Bu kişi benim

Kaya Süer Bu kişi benim

Fatime Korkmaz Bu kişi benim

Onur Ural Bu kişi benim

Sıla Akhan Bu kişi benim

Aynur Aynıoğlu Bu kişi benim

Elif Sargın Altunok Bu kişi benim

Özgür Günal Bu kişi benim

Nazan Tuna Bu kişi benim

Şükran Köse Bu kişi benim

İbak Gönen Bu kişi benim

Bahar Örmen Bu kişi benim

Nesrin Türker Bu kişi benim

Neşe Saltoğlu Bu kişi benim

Ayşe Batırel Bu kişi benim

Fatma Sırmatel Bu kişi benim

Asım Ulçay Bu kişi benim

Ergenekon Karagöz Bu kişi benim

Derviş Tosun Bu kişi benim

Alper Şener Bu kişi benim

Yayımlanma Tarihi 1 Ocak 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 33 Sayı: 1

Kaynak Göster

APA Gürbüz, Y., Tütüncü, E. E., Tülek, N. E., Kınıklı, S., vd. (2016). Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal, 33(1), 18-26.
AMA Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal. Ocak 2016;33(1):18-26.
Chicago Gürbüz, Yunus, Emin Ediz Tütüncü, Necla Eren Tülek, Sami Kınıklı, Günay Tuncer, Cemal Bulut, Süda Tekin Koruk, Bilgehan Aygen, Neşe Demirtürk, Ali Kaya, Taner Yıldırmak, Kaya Süer, Fatime Korkmaz, Onur Ural, Sıla Akhan, Aynur Aynıoğlu, Elif Sargın Altunok, Özgür Günal, Nazan Tuna, Şükran Köse, İbak Gönen, Bahar Örmen, Nesrin Türker, Neşe Saltoğlu, Ayşe Batırel, Fatma Sırmatel, Asım Ulçay, Ergenekon Karagöz, Derviş Tosun, ve Alper Şener. “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients With HCV Infection: A Multicenter, Retrospective Study”. Balkan Medical Journal 33, sy. 1 (Ocak 2016): 18-26.
EndNote Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A (01 Ocak 2016) Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal 33 1 18–26.
IEEE Y. Gürbüz, “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study”, Balkan Medical Journal, c. 33, sy. 1, ss. 18–26, 2016.
ISNAD Gürbüz, Yunus vd. “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients With HCV Infection: A Multicenter, Retrospective Study”. Balkan Medical Journal 33/1 (Ocak 2016), 18-26.
JAMA Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal. 2016;33:18–26.
MLA Gürbüz, Yunus vd. “Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients With HCV Infection: A Multicenter, Retrospective Study”. Balkan Medical Journal, c. 33, sy. 1, 2016, ss. 18-26.
Vancouver Gürbüz Y, Tütüncü EE, Tülek NE, Kınıklı S, Tuncer G, Bulut C, Koruk ST, Aygen B, Demirtürk N, Kaya A, Yıldırmak T, Süer K, Korkmaz F, Ural O, Akhan S, Aynıoğlu A, Altunok ES, Günal Ö, Tuna N, Köse Ş, Gönen İ, Örmen B, Türker N, Saltoğlu N, Batırel A, Sırmatel F, Ulçay A, Karagöz E, Tosun D, Şener A. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study. Balkan Medical Journal. 2016;33(1):18-26.