Papilledema Due to Mirtazapine

Yıl 2016, Cilt: 33 Sayı: 3, 363 - 365, 01.05.2016

Mehmet Emin Ceylan Alper Evrensel Gökçe Cömert

Öz

Background: Mirtazapine is a tetracyclic antidepressant that enhances both noradrenergic and serotonergic transmission. The most common cause of papilledema is increased intracranial pressure due to brain tumor. Also it may occur as a result of idiopathic intracranial hypertension (IIH, pseudo tumor cerebri). Moreover, papilledema may also develop due to retinitis, vasculitis, Graves’ disease, hypertension, leukemia, lymphoma, diabetes mellitus and radiation. Case Report: In this article, a patient who developed papilledema while under treatment with mirtazapine (30 mg/day) for two years and recovered with termination of mirtazapine treatment was discussed to draw the attention of clinicians to this side effect of mirtazapine. Conclusion: Idiopathic intracranial hypertension and papilledema due to psychotropic drugs has been reported in the literature. Mirtazapine may rarely cause peripheral edema. However, papilledema due to mirtazapine has not been previously reported. Although papilledema is a very rare side effect of an antidepressant treatment, fundoscopic examinations of patients must be performed regularly.

Anahtar Kelimeler

Antidepressant, mirtazapine, papilledema, side effect

Kaynakça

• 1. Alam A, Voronovich Z, Carley JA. A Review of Therapeutic Uses of Mirtazapine in Psychiatric and Medical Conditions. The Primary Care Companion for CNS Disorders 2013;15:PCC.13r01525.
• 2. Çam B, Kurt H. Mirtazapine bağlı periferik ödem: Olgu sunumu / Peripheral edema associated with mirtazapine: A case report. Anat J Psych 2013;14:84-8.
• 3. Binder DK, Horton JC, Lawton MT, McDermott MW. Idiopathic intracranial hypertension. Neurosurgery 2004;54:538-52. [CrossRef]
• 4. Spiteri MA, Geraint JD. Adverse ocular reactions to drugs. Postgrad Med J 1983;59:343-9. [CrossRef]
• 5. Blumberg AG, Klein DF. Severe papilledema associated with drug therapy. Am J Psych 1961;118:168-70. [CrossRef]
• 6. Yetimalar Beckmann Y, Seçil Y, Güngör BB. Pseudotumor cerebri in a patient being treated for bipolar disorder. General Hospital Psychiatry 2010;32:7-8. [CrossRef]
• 7. Hutcheon ML. An unexpected case of swollen optic nerves. Am J Ther 2011;18:126-9. [CrossRef]
• 8. Katzung BG, Trevor AJ. Katzung & Trevor’s Pharmacology. 8th ed. Stamford: Appleton&Lange; 1998.
• 9. Barrett K, Brooks H, Boitano S, Barman S. Ganong’s Review of Medical Physiology. 23th ed. Connecticut: Appleton&Lange; 2010.
• 10. Kuchel O, Hamet P, Cuche JL, Tolis G, Fraysse J, Genest J. Urinary and plasma cyclic adenosine 3-5 monophosphate in patients with idiopathic edema. J Clin Endocrinol Metab 1975;41:282-9. [CrossRef]