The Role of Follow-up in Monitoring the Outcomes of Prematurity in a Cohort of Romanian Infants

Yıl 2017, Cilt: 34 Sayı: 1, 21 - 27, 01.01.2017

Anca Bivoleanu Andreea Avasiloaiei Mihaela Moscalu Maria Stamatin

Öz

Background: The rate of preterm births in Romania is
one of the highest among European countries. However,
there is little information regarding the ways in which
premature birth affects the outcome in Romanian
preterm infants.
Aims: To investigate the effects of early developmental
intervention after discharge from the hospital on motor
and cognitive development in preterm infants.
Study Design: Longitudinal observational study
Methods: We performed the Amiel-Tison neurologic
evaluation at discharge and the Bayley Scales of Infant
Development from 3 to 24 months. Based on these
evaluations, an outcome score was formulated.
Results: Between 2007 and 2010, 1157 of 2793 premature
infants were included into the study. There was a negative
correlation between the number of evaluations and
the risk of developing neurologic sequelae (p<0.001).
The correlation analysis demonstrated a significant
association between the final category of risk at the end
of the follow up program and the degree of compliance
(p<0.01). At 24 months evaluation, there was a
correlation between the low gestational age and the risk
of developing severe neurologic sequelae (p<0.001).
Conclusion: This study shows the importance of
follow up program in decreasing the risk o

Anahtar Kelimeler

Neurologic sequelae, prematurity, infants, monitoring

Kaynakça

• 1. Costeloe KL, Hennessy EM, Haider S, Stacey F, Marlow N, Draper ES. Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies). BMJ 2012;345:e7976.
• 2. Boyle EM, Poulsen G, Field DJ, Kurinczuk JJ, Wolke D, Alfirevic Z, et al. Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study. BMJ 2012;344:e896.
• 3. Kerstjens JM, Bocca-Tjeertes IF, de Winter AF, Reijneveld SA, Bos AF. Neonatal morbidities and developmental delay in moderately preterm-born children. Pediatrics 2012;130:e265-72.
• 4. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010;126:443-56.
• 5. Platt MJ, Cans C, Johnson A, Surman G, Topp M, Torrioli MG, et al. Trends in cerebral palsy among infants of very low birth weight (<1500 grams) or born prematurely (<32 wk.) in 16 European centres. Lancet. 2007;369:43-50.
• 6. Marlow N, Wolke D, Bracewell MA, Samara M; EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med 2005;352:9-19.
• 7. Laroque B, Ancel PY, Marret S, Marchand L, Andre M, Arnaud C, et al ; EPIPAGE Study group. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet 2008;371:813-20.
• 8. Hack M. Adult outcomes of preterm children. J Dev Behav Pediatr 2009;30:460-70.
• 9. Bhutta AT, Cleves MA, Casey PH, Craddock MM, Anand KJS. Cognitive and behavioral outcomes of school-age children who were born preterm: a meta-analysis. JAMA 2002;288:728-37.
• 10. Steward AL, Rifkin L, Amess PN, Kirkbride V, Townsend JP, Miller DH, et al. Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm. Lancet 1999;353:1653-7.
• 11. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010;126:443-56.
• 12. Singh GK, Kenney MK, Reem M, Kogan MD, Lu MC. Mental Health Outcomes in US Children and Adolescents Born Prematurely or with Low Birthweight. Depress Res Treat 2013;2013:570743.
• 13. Taylor HG, Klein N, Minich NM, Hack M. Middle-school-age outcomes in children with very low birth weight. Child Dev 2000;71:1495-511.
• 14. Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller AB, et al. Born too soon: The global epidemiology of 15 million preterm births. Reprod Health 2013;10 Suppl 1:S2.
• 15. Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 2012;379:2162-72.
• 16. Mâțu E. Urmărirea nou-născutului cu risc pentru sechele neurologice și de dezvoltare. Asociația de Neonatologie din România, 2011. Colecția ghiduri clinice pentru neonatologie. Ghidul 13/revizia 03.12.2010. Ghiduri clinice - Ministerul Sănătății http://www.ghiduriclinice.ro/neonatologie-ghiduriclinice.php
• 17. Amiel-Tison C. Clinical assessment of the infant nervous system. In: Levene MI, Chervenak FA, Whittle M, editors. Fetal and Neonatal Neurology and Neurosurgery. London: Churchill Livingstone. 2001;99-120.
• 18. Leroux BG, N’Guyen The Tich S, Branger B, Gascoin G, Rouger V, Berlie I, et al. Neurological assessment of preterm infants for predicting neuromotor status at 2 years: results from the LIFT cohort. BMJ Open 2013;3.
• 19. Bayley N. Bayley Scales of Infant Development. 2nd ed. in: J Psychoed Assess 2000;18:185-95. http://www.pearsonclinical.com/childhood/ products/100000123/bayley-scales-of-infant-and-toddler-developmentthird-edition-bayley-iii.html
• 20. Aylward GP, Verhulst SJ, Bell S. Predictive utility of the BSID-II Infant Neurodevelopmental Screener (BINS) Risk Status Classifications. Dev Med Child Neurol J 1996;138(Suppl 74):26-36.
• 21. Dezoete JA, MacArthur BA, Tuck B. Prediction of Bayley and Stanford Binet scores with a group of very low birth weight children. Child Care Health Dev 2003;29:367-72.
• 22. Bradley RH, Corwyn RF. Socioeconomic status and child development. Annu Rev Psychol 2002;53:371-99.
• 23. Wild KT, Betancourt LM, Brodsky NL. The effect of socioeconomic status on the language outcome of preterm infants at toddler age. Early Hum Dev 2013;89:743-6.
• 24. Ruth CA, Roos N, Hildes-Ripstein E, Brownell M. The influence of gestational age and socioeconomic status on neonatal outcomes in late preterm and early term gestation: a population based study. BMC Pregnancy Childbirth 2012;12:62.
• 25. Johnson S, Wolke D, Hennessy E, Smith R, Trikic R, Marlow N. Academic attainment and special educational needs in extremely preterm children at 11 years of age: the EPICure study. Arch Dis Child Fetal Neonatal Ed 2009;94:F283-9.
• 26. Litt JS, Gerry Taylor H, Margevicius S, Scluchtter M, Andreias L, Hack M. Academic achievement of adolescents born with extremely low birth weight. Acta Paediatr 2012;101:1240-5.
• 27. Beaino G, Khoshnood B, Kaminski M, Marret S, Pierrat V, Vieux R, et al ; EPIPAGE Study Group. Predictors of the risk of cognitive deficiency in very preterm infants: the EPIPAGE prospective cohort. Acta Paediatr 2011;100:370-8.
• 28. Aarnoudse-Moens CS, Weisglas-Kuperus N, van Goudoever JB, Oosterlaan J. Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics 2009;124:717-28.
• 29. Potijk MR, Kerstjens JM, Bos AF, Reijneveld SA, de Winter AF. Developmental delay in moderately preterm-born children with low socioeconomic status: risks multiply. J Pediatr 2013;163:1289-95.
• 30. Cserjesi R, VAN Braeckel KN, Timmerman M., Butcher PR, Kerstjens JM, Reijneveld SA, et al. Patterns of functioning and predictive factors in children born moderately preterm or at term. Dev Med Child Neurol 2012;54:710-5.