Urothelial Carcinoma of the Bladder in Pediatric Patient: Four Case Series and Review of the Literature

Yıl 2018, Cilt: 35 Sayı: 3, 268 - 271, 01.05.2018

Murat Uçar Metin Demirkaya Berna Aytaç Vuruşkan Emin Balkan Nizamettin Kılıç

Öz

Background: Urothelial carcinoma of the bladder is a rare condition
in children, and most cases in this age group are noninvasive and
low-grade. However, no follow-up protocol has been defined for this
patient group. The objective of this study was to draw attention to
bladder tumors in children and focus on the current recommendations
for postoperative follow-up along with a case study of four patients.
Case Report: Four patients aged <18 years with urothelial carcinoma
who were treated in our clinics between 2001 and 2015 were
retrospectively evaluated. The results were compared with those of
published pediatric case series in the literature. No abnormalities were
found in the patients’ physical examinations and laboratory analyses,
except hematuria (microscopic or macroscopic). Ultrasonography
was used in all the patients to detect lesions in the bladder. Surgical
resections were performed endoscopically, except in one patient.
Histopathological evaluations revealed low-grade superficial
urothelial carcinoma. No recurrence or complication was observed
for all patients.
Conclusion: Although rarely encountered during childhood,
urothelial carcinoma should be considered as a differential diagnosis
in pediatric patients with hematuria.

Anahtar Kelimeler

Bladder, children, transitional cell carcinoma, treatment

Kaynakça

• 1. Chu S, Singer J. Transitional Cell Carcinoma in the pediatric patient: a review of the literature. Urology 2016;91:175-9.
• 2. Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI. Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the word health organization 2004 bladder consensus classification. J Urol 2005;174:1976-80.
• 3. Hoenig DM, McRae S, Chen SC, Diamond DA, Rabinowitz R, Caldamone AA. Transitional cell carcinoma of the bladder in the pediatric patient. J Urol 1996;156:203- 5.
• 4. Bujons A, Caffaratti J, Garat JM, Villavicencio H. Long-term follow-up of transitional cell carcinoma of the bladder in childhood. J Pediatr Urol 2014;10:167-70.
• 5. Paner GP, Zehnder P, Amin AM, Husain AN, Desai MM. Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management. Adv Anat Pathol 2011;18:79-89.
• 6. Lerena J, Krauel L, Garcia-Aparicio L, Vallasciani S, Sunol M, Rodo J. Transitional cell carcinoma of the bladder in children and adolescents: six-case series and review of the literature. J Pediatr Urol 2010;6:481-5.
• 7. Rodriguez A, Burday D, Sexton W, Ahmad N, Pow-Sang JM. Urothelial carcinoma in a child. Arch Esp Urol 2005;58:473-5.
• 8. Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G. Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease. Int Braz J Urol 2016;42:242-6.
• 9. Ander H, Dönmez Mİ, Yitgin Y, Tefik T, Ziylan O, Oktar T, et al. urothelial carcinoma of the urinary bladder in pediatric patients: a long term follow up. Int Urol Nephrol 2015;47:771-4.
• 10. Berrettini A, Castagnetti M, Salerno A, Nappo SG, Manzoni G, Rigamonti W, et al. Bladder urothelial neoplasms in pediatric age: Experience at three tertiary centers. J Ped Urol 2015;11:26.