Bazı borlu bileşiklerin anti-quorum sensing inhibitör aktivitelerinin belirlenmesi

Öz

Bor, başta bitkiler ve bazı hayvanlar olmak üzere canlılar için önemli elementlerden biridir. Borun insanlık için önemi giderek artmakta ve kullanım alanları da buna paralel olarak genişlemektedir. Bu çalışmada, 5 farklı bor bileşiğinin quorum-sensing inhibisyon etkileri araştırılmıştır. Quorum-sensing inhibisyon deneyi CV026 ve CV12472 üzerinde broth dilüsyon yöntemi kullanılarak gerçekleştirilmiştir. Çalışma sonuçları dikkate alındığında, en yüksek violacein inhibisyon aktivitesinin %74,46 ile sodyum tetraborat tarafından sağlandığı belirlenmiştir. Quorum sensing aktivitesi baz alındığında ise bor oksit ve sodyum tetraboratın MİK değerinin %95,15 ile en yüksek inhibisyon oranını sağladığı ortaya çıkmıştır. Çalışmadan elde edilen anti-quorum sensing aktivite verileri incelendiğinde, bu bor bileşiklerinin yüksek aktivite gösterdiği ve hayvan deneyleri gibi farklı testlerle desteklenmesi gerektiği görülmektedir.

Anahtar Kelimeler

• borlu bileşikler
• Quorum algılama inhibisyonu
• Violacein indirgenmesi

Investigation of anti-quorum sensing inhibition activity of some boron compounds

Öz

Boron is one of the important elements for organisms, especially for plants and animals. The importance of boron for humanity is increasing, and its uses are parallelly expanding. In this study, the quorum-sensing inhibition effects of five different boron compounds were investigated. The quorum-sensing inhibition assay was performed on CV026 and CV12472 using the broth dilution method. Considering the results of this study, it was determined that the highest violacein inhibition activity was provided by sodium tetraborate with 74.46%. Based on the quorum sensing activity, it was revealed that the minimum inhibitory concentration (MIC) value of boron oxide and sodium tetraborate provided the highest inhibition rate 95.15%. When the anti-quorum sensing activity data obtained from the study are examined, it was seen that these boron compounds showed high activity and should be supported by different tests such as animal experiments.

Anahtar Kelimeler

• boron compounds
• Quorum sensing inhibition
• Violacein reduction

Kaynakça

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