Bone Cement Formulation with Reduced Heating of Bone Cement Resin

Yıl 2021, Cilt: 6 Sayı: 2, 274 - 282, 30.06.2021

M.ozgur Seydibeyoglu , Muserref Caka Fulden Ulucan-karnak , Günnur Onak , Ataç Uzel , Figen Özyıldız Ozan Karaman

https://doi.org/10.30728/boron.835919

Öz

Bone cement material is one of the key materials in bone surgery and orthopedic medicine. In this study, commercial polymethyl-methacrylate bone cement was mixed with boric acid and zinc borate to reduce the reaction temperature of the bone cement. The observation of temperature changes during the polymerization using laser thermometer and thermal camera showed that the use of boron compounds decreased the temperature of the bone cement at least 10 °C which is very critical for the biomaterial uses as it affects the biocompatibility of the material. Besides temperature monitoring, microbiological tests showed that the materials have certain antibacterial effect. Water contact angle studies also supported the biocompatibility studies. In the last part, mechanical tests showed that there was not significant change in the tensile strength and tensile modulus values. Antibacterial tests exhibited that zinc borate addition shows antimicrobial activity against S.epidermidis as well as boric acid addition over %5 concentration. According to the cell culture studies, boric acid can be interpreted as non-toxic up to 10%, while 10% and 20% zinc borate has toxic effect. This is the first study to use boron compounds in bone cement and it is proved that boric acid at low concentrations can be used for bone cement applications but zinc borate would not be suitable to use in medical applications due to toxic effects.

Anahtar Kelimeler

Bone Cement, Boron Minerals, Thermal Characterization

Destekleyen Kurum

İzmir Katip Celebi University

Proje Numarası

2016-TYL-FEBE-0033

Teşekkür

This study was supported by Izmir Katip Celebi University as 2016-TYL-FEBE-0033 as a master thesis study of Muserref Caka. We would like to thank Prof. Ahmet Murat Bülbül, Prof. Mehmet Emin Erdil, and Dr. Ersin Kuyucu for the great support on the initiation of this study. Prof. Seyhun Solakoglu was also very helpful for the biocompatibility tests. Also we would like to thank research assistant Metehan Atagür for his help during the experiments.

Azaltılmış Isıl Özellikli Bor Katkılı Kemik Çimentosu Üretimi

Öz

Kemik çimentosu malzemesi, kemik cerrahisi ve ortopedik tıpta anahtar malzemelerden biridir. Bu çalışmada, ticari polimetil-metakrilat kemik çimentosu, kemik çimentosunun reaksiyon sıcaklığını düşürmek için borik asit ve çinko borat ile karıştırılmıştır. Lazer termometre ve termal kamera kullanılarak polimerizasyon sırasında sıcaklık değişimlerinin gözlemlenmesi, bor bileşiklerinin kullanımının kemik çimentosunun sıcaklığını en az 10 ° C düşürdüğünü göstermiştir ki bu, malzemenin biyouyumluluğunu etkilediği için biyomateryal kullanımlar için çok kritiktir. Mikrobiyolojik testler, sıcaklık izlemenin yanı sıra, malzemelerin belirli antibakteriyel etkiye sahip olduğunu göstermiştir. Su temas açısı çalışmaları da biyouyumluluk çalışmalarını desteklemiştir. Son bölümde, mekanik testler, çekme dayanımı ve çekme modülü değerlerinde önemli bir değişiklik olmadığını göstermiştir. Antibakteriyel testler, çinko borat ilavesinin ve %5 konsantrasyonun üzerindeki borik asit ilavesinin S. epidermidis'e karşı antimikrobiyal aktivite gösterdiğini göstermiştir. Hücre kültürü çalışmalarına göre borik asit% 10'a kadar toksik olmayan katkı olarak yorumlanabilirken,% 10 ve % 20 çinko borat katkısının toksik etkisi olduğu görülmüştür. Bu çalışma, kemik çimentosunda bor bileşiklerinin kullanıldığı ilk çalışmadır ve düşük konsantrasyonlarda borik asit katkısının kemik çimentosu uygulamaları için kullanılabileceği ancak çinko boratın toksik etkilerinden dolayı tıbbi uygulamalarda kullanılmasının uygun olmayacağı kanıtlanmıştır.

Anahtar Kelimeler

Kemik çimentosu,, boron minerali, termal karakterizasyon

Proje Numarası

2016-TYL-FEBE-0033

Kaynakça

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