Veteriner Fitoterapide Yara Bakımında Yaygın Olarak Kullanılan Bitkiler

Yıl 2021, Cilt: 2 Sayı: 2, 73 - 79, 31.12.2021

Ayşe Gölgeli Bedir , Ferda Turgut

Öz

Fitoterapi dünya çapında yara iyileşmesinde yaygın olarak kullanılan bir yöntemdir. Fitoterapide sıklıkla aloe vera, çay ağacı yağı, sarı kantaron, kudret narı, biberiye, aynısefa, yeşil çay, gotu kola bitkileri kullanılmaktadır. Pek çok bilimsel çalışma bu bitkilerden elde edilen ekstraktların antibakteriyel, kollajen sentezini arttırıcı, yara iyileşmesinin proliferasyon fazını ve fibroblastları uyarıcı etkisi olduğunu ve bu sayede yara iyileştirmesini hızlandırdığını rapor etmiştir. Fitoterapi alanında yapılan gelişmelerle birlikte çoğu bitkiler preparatlaştırılmış ve ticari olarak kullanıma sunulmuştur. Daha çok oral veya topikal olarak uygulanan bu preparatların kullanımına göre bazı avantaj ve dezavantajları bulunmaktadır. Bu derleme veteriner fitoterapide yaygın olarak kullanılan fitoterapik bitkilerin özellikleri hakkında bilgi vermek amacıyla yazılmıştır.

Anahtar Kelimeler

Aloe vera, Çay ağacı yağı, Fitoterapi, Kudret narı, Sarı kantaron, Yara iyileşmesi

Plants Widely Used in Wound Care in Veterinary Phytotherapy

Öz

Phytotherapie is an approach widespread employed in wound healing. Aloe vera, Tea tree oil, St. John's wort, Bitter gourd, Rosemary, Calendula, Green tea, Gotu Kola plants are often used in phytotherapy. Previous studies have reported that the extracts obtained from plants have antibacterial effects, increasing collagen synthesis, stimulating the proliferation phase of wound healing and fibroblasts, thereby accelerating wound healing. With the developments in the field of phytotherapy, most plants have been prepared and commercially available. There are some advantages and disadvantages compared to the employed preparations, which are mostly applied oral or topical. This review was written in order to provide information about the properties of widely used phytotherapeutic plants in veterinary medicine field.

Anahtar Kelimeler

Wound healing, Phytotherapy, Aloe vera, Tea tree oil, Bitter gourd, St. John

Kaynakça

• 1. Dat AD, Poon F, Pham KB, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database of Systematic Reviews 2012; 15: 1-26 . doi: 10.1002/14651858.cd008762.pub2
• 2. Shah A, Amini-Nik S. The role of phytochemicals in the inflammatory phase of wound healing. International Journal of Molecular Sciences 2017; 18: 1-17. doi: 10.3390/ijms18051068.
• 3. Farahpour MR. Medicinal plants in wound healing. Dogan KH.eds. In: Wound Healing-Current Perspectives. Croatia: Intechopen, 2019; pp. 33-47.
• 4. Dorai AA. Wound care with traditional, complementary and alternative medicine. Indian Journal of Plastic Surgery 2012; 45: 418-424. doi: 10.4103/0970-0358.101331.
• 5. Yazar H, Karaca İR. Yumuşak dokuda yara iyileşmesi, etkileyen faktörler ve skar revizyonu. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2016; 15: 152-161.
• 6. Yalçin H, Özkalp B. Vücut Hijyeninin Önemi ve Yara Bakımında Yeni Gelişmeler. 4. Ulusal Sterilizasyon Dezenfeksiyon Kongresi. Nisan, 20-24, 2005; Samsun-Türkiye.
• 7. Sançar B, Canbulat Ş, İlhan S. Yara Bakımında Kullanılan Bitkisel Yöntemler ve Hemşirelik. Turkiye Klinikleri Internal Medicine Nursing-Special Topics 2017; 3: 116-124.
• 8. De Almeida Neves AL, Komesu MC, Di Matteo MAS. Effects of green tea use on wound healing. Int j Morphol 2010; 28: 905-910. doi: 10.4067/S0717-95022010000300039.
• 9. Sharma P, Srivastava S, Kumar R, Singh V. Phytotherapy: An alternative low cost therapeutic management of endometritis in dairy animals: A review. Int J Curr Microbiol App Sci 2018; 7: 4581-4591.
• 10. Tresch M, Mevissen M, Ayrle H, Melzig M, Roosje P, et al. Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review. BMC Veterinary Research 2019; 15: 1-19. doi: 10.1186/s12917-019-1854-4.
• 11. Türsen B, Türsen Ü. Dermatolojide aloe vera. Dermatoz, c. 2014; 5: 1-11. doi: 10.15624.dermatoz14054d1.
• 12. Davis RH, Donato J, Hartman GM, Haas RC. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Journal of the American Podiatric Medical Association 1994; 84: 77-81. doi: 10.7547/87507315-84-2-77.
• 13. Boudreau MD, Beland FA. An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. Journal of Environmental Science and Health Part C 2006; 24: 103-154. doi: 10.1080/10590500600614303.
• 14. Schäfer M, Werner S. Oxidative stress in normal and impaired wound repair. Pharmacological Research 2008; 58: 165-171. doi: 10.1016/j.phrs.2008.06.004.
• 15. Nejatzadeh-Barandozi F. Antibacterial activities and antioxidant capacity of Aloe vera. Organic and Medicinal Chemistry Letters 2013; 3: 1-8. doi: 10.1186/2191-2858-3-5.
• 16. Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N. Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytotherapy Research 2001; 15: 157-161. doi: 10.1002/ptr.719.
• 17. Takzare N, Hosseini M-j, Hasanzadeh G, Mortazavi H, Takzare A, et al. Influence of Aloe Vera gel on dermal wound healing process in rat. Toxicology Mechanisms and Methods 2009; 19: 73-77. doi: 10.1080/15376510802442444.
• 18. Sürme Y, Çürük GN. Yara Bakiminda Fitoterapi: Çay ağacı yağı. ERÜ Sağlık Bilimleri Fakültesi Dergisi 2020; 7: 35-41.
• 19. Yadav E, Kumar S, Mahant S, Khatkar S, Rao R. Tea tree oil: a promising essential oil. Journal Of Essential Oil Research 2017; 29: 201-213. doi: 10.1080/10412905.2016.1232665.
• 20. Li X, Shen D, Zang Q, Qiu Y, Yang X. Chemical Components and Antimicrobial Activities of Tea Tree Hydrosol and Their Correlation With Tea Tree Oil. Natural Product Communications 2021; 16: 1-7. doi: 10.1177%2F1934578X211038390.
• 21. Tharmarajah B, Coroneo MT. Corneal Effects of Tea Tree Oil. Cornea 2021; 40: 1363-1364. doi:10.1097/ico.0000000000002776.
• 22. Rubianti MA, Ervianti E, Listiawan MY, Mira D, Indramaya R et al. Efficacy of 5% Tea Tree Oil Hydrogel on Healing Morbus Hansen's Chronic Plantar Ulcer. Age 2021; 13: 28-33.
• 23. Fitzi J, Fürst-Jucker J, Wegener T, Saller R, Reichling J. Phytotherapy of chronic dermatitis and pruritus of dogs with a topical preparation containing tea tree oil (Bogaskin®). Schweizer Archiv für Tierheilkunde 2002; 144: 223-231. doi: 10.1024/0036-7281.144.5.223
• 24. Weseler A, Geiss H, Saller R, Reichling J. Antifungal effect of Australian tea tree oil on Malassezia pachydermatis isolated from canines suffering from cutaneous skin disease. Schweizer Archiv für Tierheilkunde 2002; 144: 215-221. doi: 10.1024/0036-7281.144.5.215
• 25. Khan SA, McLean MK, Slater MR. Concentrated tea tree oil toxicosis in dogs and cats: 443 cases (2002–2012). Journal of the American Veterinary Medical Association 2014; 244: 95-99. doi: 10.2460/javma.244.1.95.
• 26. Bischoff K, Guale F. Australian tea tree (Melaleuca alternifolia) oil poisoning in three purebred cats. Journal of Veterinary Diagnostic Investigation 1998; 10: 208-210.
• 27. Saddiqe Z, Naeem I, Maimoona A. A review of the antibacterial activity of Hypericum perforatum L. Journal of Ethnopharmacology 2010; 131: 511-521. doi: 10.1016/j.jep.2010.07.034.
• 28. Samadi S, Khadivzadeh T, Emami A, Moosavi NS, Tafaghodi M, et al. The effect of Hypericum perforatum on the wound healing and scar of cesarean. The Journal of Alternative and Complementary Medicine 2010; 16: 113-117. doi: 10.1089/acm.2009.0317.
• 29. Altıparmak M, Eskitaşçıoğlu T. Comparison of systemic and topical Hypericum perforatum on diabetic surgical wounds. Journal of Investigative Surgery. 2018; 31: 29-37. doi: 10.1080/08941939.2016.1272654.
• 30. Seyhan N. Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats. Evidence-Based Complementary and Alternative Medicine 2020; 2020: 1-5. doi: 10.1155/2020/6462956.
• 31. Gunpinar S, Kilic OA, Duran I, Tosun M, Firat T et al. Evaluation of the effect of topical Hypericum perforatum oil on excisional palatal wound healing in rabbits. Journal of Investigative Surgery 2020; 33: 49-58. doi: 10.1080/08941939.2018.1474980.
• 32. Carnevali F, Franchini D, Otranto D, Giangaspero A, Di Bello A et al. A formulation of neem and hypericum oily extract for the treatment of the wound myiasis by Wohlfahrtia magnifica in domestic animals. Parasitology Research 2019; 118: 2361-2367. doi: 10.1007/s00436-019-06375-x.
• 33. İskender İ, Çiğirgil N, Gümüştaş B, Güldü ÖK, Karaman D, Medine Eİ et al. Geleneksel Olarak Yara Tedavisinde Kullanılan Kudret Narı (Momordica charantia L.) Zeytinyağı Maseratı Kullanılarak Krem Formunun Geliştirilmesi ve İn Vitro Yara İyi Edici Etkisinin Araştırılması. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 2019; 12: 38-48. doi: 10.18185/erzifbed.487150.
• 34. Kisacik ÖG, Güneş ÜY. Yara iyileşmesinde kudret narının etkisi. Spatula DD. 2017; 7: 53-59. doi: 10.5455/spatula.20170628101821.
• 35. Ono T, Tsuji T, Sakai M, Yukizaki C, Ino H, et al. Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp. Cytokine 2009; 46: 119-126. doi: 10.1016/j.cyto.2008.12.016.
• 36. Kumar KS, Bhowmik D. Traditional medicinal uses and therapeutic benefits of Momordica charantia Linn. International Journal of Pharmaceutical Sciences Review and Research 2010; 4: 23-28.
• 37. Altinterim B. Bitter melon (Momordica charantia) and the effects of diabetes disease. Uludağ Üniversitesi Ziraat Fakültesi Dergisi 2012; 26: 65-70.
• 38. Pişkin A, Altunkaynak BZ, Tümentemur G, Kaplan S, Yazıcı ÖB, et al. The beneficial effects of Momordica charantia (bitter gourd) on wound healing of rabbit skin. Journal of Dermatological Treatment 2014; 25: 350-357. doi: 10.3109/09546634.2012.713459.
• 39. Malayoğlu HB. Biberiyenin (Rosmarinus officinalis L.) antioksidan etkisi. Hayvansal Üretim 2010; 51: 59-67.
• 40. Erkan N, Ayranci G, Ayranci E. Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol. Food Chemistry 2008; 110: 76-82. doi:10.1016/j.foodchem.2008.01.058.
• 41. De Macedo LM, Santos ÉMd, Militão L, Tundisi LL, Ataide JA, Souto EB, et al. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and its topical applications: a review. Plants 2020; 9: 1-12. doi: 10.3390/plants9050651.
• 42. Nejati H, Farahpour MR, Nagadehi MN. Topical Rosemary officinalis essential oil improves wound healing against disseminated Candida albicans infection in rat model. Comparative Clinical Pathology 2015; 24: 1377-1383. doi: 10.1007/s00580-015-2086-z.
• 43. Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacology and Physiology 2014; 27: 303-310. doi: 10.1159/000357477.
• 44. Bakırel T, Bakırel U, Keleş OÜ, Ülgen SG, Yardibi H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. Journal of Ethnopharmacology 2008; 116: 64-73. doi: 10.1016/j.jep.2007.10.039.
• 45. Juhas S, Bukovska A, Cikos S, Czikkova S, Fabian D, et al. Anti-inflammatory effects of Rosmarinus officinalis essential oil in mice. Acta Veterinaria Brno 2009; 78: 121-127. doi: 10.2754/avb200978010121.
• 46. Yilmaz R, Özyildiz Z, Temmaoğullari F, Hayat A. The Effects of Rosemary (Rosemarinus officinalis) Extract on Wound Healing in Rabbits. Fırat Üniversitesi Sağ Bil Vet Dergisi 2012; 26: 105-109.
• 47. Muley B, Khadabadi S, Banarase N. Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): a review. Tropical Journal of Pharmaceutical Research 2009; 8: 455-465. doi: 10.4314/tjpr.v8i5.48090.
• 48. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews 2000; 52: 673-751.
• 49. Givol O, Kornhaber R, Visentin D, Cleary M, Haik J, Harats M. A systematic review of Calendula officinalis extract for wound healing. Wound Repair and Regeneration 2019; 27: 548-561. doi: 10.1111/wrr.12737. 50. Nicolaus C, Junghanns S, Hartmann A, Murillo R, Ganzera M et al. In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. Journal of Ethnopharmacology 2017; 196: 94-103. doi: 10.1016/j.jep.2016.12.006.
• 51. Mehrabani D, Ziaei M, Hosseini S, Ghahramani L, Bananzadeh A, et al. The effect of Calendula officinalis in therapy of acetic acid induced ulcerative colitis in dog as an animal model. Iranian Red Crescent Medical Journal 2011; 13: 884.
• 52. Mishra AK, Mishra A, Chattopadhyay P. Screening of acute and sub-chronic dermal toxicity of Calendula officinalis L essential oil. Regulatory Toxicology and Pharmacology 2018; 98: 184-189. doi: 10.1016/j.yrtph.2018.07.027.
• 53. Fujihara T, Nakagawa-Izumi A, Ozawa T, Numata O. High-molecular-weight polyphenols from oolong tea and black tea: purification, some properties, and role in increasing mitochondrial membrane potential. Bioscience, biotechnology, and biochemistry 2007; 71: 711-719. doi: 10.1271/bbb.60562.
• 54. Kim B-R, Cheong J-T, Park H-J, Yun Y-M, Lee K-K, et al. Effect of green tea extract on healing of contaminated wound in dogs. Journal of Veterinary Clinics 2007; 24: 550-556.
• 55. 55. Chang H-S, Hwang H-J, Kang E-H, Lee J-H, Chung D-J, et al. The effect of green tea bag in dogs with periodontal disease. Journal of Veterinary Clinics 2009; 26:41-47.
• 56. Prakash V, Jaiswal N, Srivastava M. A review on medicinal properties of Centella asiatica. Asian J Pharm Clin Res 2017; 10: 69. doi: 10.22159/ajpcr.2017.v10i10.20760.
• 57. Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii I Alergologii 2013; 30: 46. doi: 10.5114%2Fpdia.2013.33378.
• 58. Ro W-b, Kang M-h, Song D-w, Kim H-s, Lee G-W, et al. Application of Topical Madecassoside Cream in Dogs and Cats with Skin Diseases. Journal of Veterinary Clinics 2021; 38: 56-62. doi: 10.17555/jvc.2021.04.38.2.56.
• 59. Ho PJ, Sung JJ, Cheon KK, Tae HJ. Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis. Phytomedicine 2018; 43: 110-119. doi: 10.1016/j.phymed.2018.04.013.
• 60. Akgül MB, Başer E, Gülaydin A, Şindak N. Bir atta blanket’e bağlı kuyruk yaralanması olgusu. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 2016; 35: 49-52.
• 61. Ruszymah BHI, Chowdhury SR, Manan NABA, Fong OS, Adenan MI, Saim AB. Aqueous extract of Centella asiatica promotes corneal epithelium wound healing in vitro. Journal of Ethnopharmacology 2012; 140: 333-338. doi: 10.1016/j.jep.2012.01.023.