Nörogenetik Hastalıklarda Alternatif Model Organizma: Köpekler

Yıl 2021, Cilt: 2 Sayı: 2, 96 - 100, 31.12.2021

Sinan Kandır

Bu makale için 30 Haziran 2022 tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/bozokvetsci/issue/70492/1135174

Öz

Köpekler, evcilleştirilme serüvenlerinde insanla yalnızca davranışsal olarak yakınlaşmakla kalmamış, birçok hastalığı da birlikte yaşar hale gelmiştir. Biyomedikal araştırmalar için uzun süreli, pahalı ve çok kontrollü deney hayvanları modelleri oluşturulmaktadır. Bunun yerine doğal olarak hastalığa sahip köpeklerin etik ve deontolojik kurallar çerçevesinde diagnostik, prognostik ve terapötik olarak değerlendirilmesi hem insan hem de hayvan tıbbında genetik hastalıkların fizyopatolojik mekanizmalarının anlaşılmasını kolaylaştırarak, yeni gen ve hücresel tedavi seçeneklerine olanak sağlayacaktır. Bu derlemede, translasyonel araştırmalar yapmayı hedefleyen bilim insanlarına, köpeklerin insanlardaki ile benzer nörogenetik hastalıkları hakkında bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler

Nöron, Genetik, Köpek genetiği, Translasyonel tıp

Alternative Model Organism in Neurogenetic Diseases: Dogs

Bu makale için 30 Haziran 2022 tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/bozokvetsci/issue/70492/1135174

Öz

The human has not been intimated the dog as only a behavioral during its domestication journey, but also many diseases have become to live together. Long-term, expensive and highly controlled experimental animal models are created for biomedical research. Instead of this, the use of naturally diseased dogs in the framework of ethical and deontological rules will facilitate understanding the physiopathological mechanisms of genetic diseases in both human and animal medicine. Thus, new gene and cell therapy options will be enabled. In this review, was aimed to give information, whose desired to do translational research, about canine neurogenetic diseases likely as humans.

Anahtar Kelimeler

Neuron, Genetic, Canine genetics, Translational medicine

Kaynakça

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