Hayvanlarda Kullanılan Bazı İmmunstimülanların Genel Özellikleri ve Farklı Hayvan Türlerinde Yapılan Çalışmalar

Yıl 2021, Cilt: 2 Sayı: 2, 108 - 114, 31.12.2021

Ömer Aydın M. Sinan Aktaş

Öz

İmmunstimülanlar çeşitli bakteriyel ve viral hastalıklara karşı hayvanların immun sistemini uyaran maddelerdir. Antijene karşı spesifik olmayan bir biçimde bağışıklık sistemini uyarmaktadır. İmmunstimülanlar bakteriyel ürünler, kompleks karbonhidratlar, aşılar, immun sistemi uyaran ilaçlar, nutrisyonel faktörler, hayvansal ve bitkisel ekstratlar ve sitokinler olarak sınıflandırılmaktadır. Hastalıklara kaşı direnci artırmak için tek başlarına kullanılabildikleri gibi hastalığın türene özgü olarak antibakteriyel, antiviral ya da antiparaziter ilaçlarla birlikte de kullanılabilmektedirler. Bu derlemede hayvanlarda kullanılan bazı immünstimülanların genel özellikleri ve farklı hayvan türlerindeki çalışmalardan bahsedilmesi amaçlanmıştır.

Anahtar Kelimeler

İmmünstimülatör ilaçlar, İmmün sistem, İmmünsistem aktivasyonu, İmmünoterapi

General Characteristics of Some Immune Stimulants Used in Animals and Studies in Different Animal Species

Öz

Immunstimulants are substances that stimulate the immune system of animals against various bacterial and viral diseases. It stimulates the immune system non-specifically against the antigen. Immunstimulants are classified as bacterial products, complex carbohydrates, vaccines, immune system stimulating drugs, nutritional factors, animal and herbal extracts and cytokines. They can be used alone to increase resistance to diseases, as well as in combination with antibacterial, antiviral or antiparasitic drugs specific to the type of disease. In this review, it is aimed to talk about the general properties of some immunostimulants used in animals and studies in different animal species.

Anahtar Kelimeler

Immunstimulatory drugs, Immune system, Immune system activation, Immunotheraphy

Kaynakça

• 1. Aboughe-Angone S, Nguema-Ona E, Boudjeko T, Driouich A. Plant cell wall polysaccharides: immunomodulators of the immune system and source of natural fibers. Currents Topics in Phytochemistry 2012; 1: 1-16.
• 2. Eid G, Zaghioul WA, Awaad AHH, Bastamy MA, Michael A. Role of Corynebacterium cutis as an immune stimulant on the immune response of chickens against fowl pox virus. Veterinary Medical Journal 1995; 43: 219–229.
• 3. Shahbazi S, Bolhassani A. Immunostimulants: Types and Functions. Journal of Medical Microbiology and Infectious Diseases 2016; 4: 45-51.
• 4. Galeotti M. Some aspects of the application of immunostimulants and a critical review of methods for their evaluation. Journal of Applied Ichthyology 1998; 14: 189-199.
• 5. Padilla L, Matsui T, Ikeda S, Kitagawa M, Yano H. The effect of vitamin C supplementation on plasma concentration and urinary excretion of vitamin C in cattle. Journal of Animal Science 2007; 85: 3367-3370. doi: 10.2527/jas.2007-0060.
• 6. Egbenwiyi TN, Nwaosu SC, Salami HA. Haematological values of apparently healthy sheep and goats as influenced by age and sex in arid zone of Nigeria. African Journal of Biomedical Research 2000; 3: 109-115.
• 7. Wolf G. Uptake of ascorbic acid by human neutrophils. Nutrition Reviews 1993; 51: 337-338. doi: 10.1111/j.1753-4887.1993.tb03760.x.
• 8. Goetzl EJ, Wasserman SI, Gigli I, Austen KF. Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid. The Journal of Clinical Investigation 1974; 53: 813-818. doi: 10.1172/JCI107620.
• 9. Siegel BV. Enhancement of interferon production by poly(rI)-poly(rC) in mouse cell cultures by ascorbic acid. Nature 1975; 254: 531-532. doi: 10.1038/254531a0.
• 10. Bulger EM, Garcia I, Maier RV. Intracellular antioxidant activity is necessary to modulate the macrophage response to endotoxin. Shock 2002; 18: 58–63. doi: 10.1097/00024382-200207000-00011.
• 11. Pardue SL, Thaxton JP. Evidence for amelioration of steroid-mediated immunosuppression by ascorbic acid. Poultry Science 1984; 63: 1262-1268. doi: 10.3382/ps.0631262.
• 12. Rizk MA, Abdalla AA, El-Sayed SAES. Evaluation of Ascorbic Acid in Combination of Ivermectin in Augmentation the Recovery from Juvenile Generalized Demodicosis in Dogs: A Randomized Clinical Trial. PSM Veterinary Research 2017; 2: 14-21.
• 13. Naresh R, Dwivedi SK, Swarup D, Patra RC. Evaluation of Ascorbic Acid Treatment in Clinical and Subclinical Mastitis of Indian Dairy Cows. Asian-Australasian Journal of Animal Sciences 2002; 15: 905-911.
• 14. Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nature clinical practice Rheumatology 2008; 4: 404-412. doi: 10.1038/ncprheum0855.
• 15. Nelson CD, Reinhardt TA, Lippolis JD, Sacco RE, Nonnecke BJ. Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements. Nutrients 2012; 4: 181-196. doi: 10.3390/nu4030181.
• 16. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System. Archives of Biochemistry and Biophysics 2000; 374: 334-338. doi: 10.1006/abbi.1999.1605.
• 17. Reinhardt TA, Stabel JR, Goff JP. 1,25-dihydroxyvitamin D3 enhances milk antibody titers to Escherichia coli J5 vaccine. Journal of Dairy Science 1999; 82: 1904-1909. doi: 10.3168/jds.S0022-0302(99)75425-1.
• 18. Jaffey JA, Backus RC, McDaniel KM, DeClue AE. Serum vitamin D concentrations in hospitalized critically ill dogs. PLoS One 2018; 13: e0194062. doi: 10.1371/journal.pone.0194062.
• 19. Erdogan H, Ural K, Pasa S. Relationship between mean platelet volume, low-grade systemic coagulation and Vitamin D deficiency in canine visceral leishmaniasis. Medycyna Weterinaryjna 2019; 75:493-496. doi: https://doi.org/10.21521/mw.6252.
• 20. Rimbach G, Fischer A, Pallauf J, Virgili F. Vitamin E and selenium effects on differential gene expression. In The antioxidant vitamins C and E. Proceedings of a symposium held at the 2002 World Congress of the Oxygen Club of California. March, 6-9, 2002; California-USA.
• 21. Hidiroglou N, Cave N, Atwall AS, Farnworth ER, McDowell LR. Comparative vitamin E requirements and metabolism in livestock. Annales de Recherches Veterinaires 1992; 23: 337-359. 22. Zingg JM. Vitamin E and mast cells. Vitamins & Hormones 2007; 76: 393-418. doi: 10.1016/S0083-6729(07)76015-6.
• 23. Moriguchi S, Miwa H, Okamura M, Maekawa K, Kishino Y, et al. Vitamin E is an important factor in T cell differentiation in thymus of F344 rats. Journal of Nutritional Science and Vitaminology 1993; 39: 451-463. doi: 10.3177/jnsv.39.451.
• 24. Afzal M, Tengerdy RP, Ellis RP, Kimberling CV, Morris CJ. Protection of rams against epididymitis by a Brucella ovis-vitamin E adjuvant vaccine. Veterinary Immunology and Immunopathology 1984; 7: 293-304. doi: 10.1016/0165-2427(84)90087-4.
• 25. Kandil OM, Abou-Zeina HA. Effect of parenteral vitamin E and selenium supplementation on immune status of dogs vaccinated with subunit and somatic antigens against Taenia hydatigena. Journal of the Egyptian Society of Parasitology 2005; 35: 537-550.
• 26. Pompeu MA, Cavalcanti LFL, Torala FLB. Effect of vitamin E supplementation on growth performance, meat quality, and immune response of male broiler chickens: a meta-analysis. Livestock Science 2018; 208: 5-13. doi: doi:10.1016/j.livsci.2017.11.021.
• 27. Samanta AK, Dass RS, Rawat M, Mishra SC, Mehra UR. Effect of dietary vitamin E supplementation on serum α-Tocopherol and immune status of crossbred calves. Asian-Australasian Journal of Animal Sciences 2006; 19: 500-506.
• 28. Mustacich D, Powis G. Thioredoxin reductase. Biochemistry Journal 2000; 346: 1-8. doi: 10.1042/bj3460001.
• 29. Arthur JR, McKenzie RC, Beckett GJ. Selenium in the immune system. The Journal of Nutrition 2003; 133: 1457S- 1459S. doi: 10.1093/jn/133.5.1457S.
• 30. Beytut E, Karatas F, Beytut E. Lambs with white muscle disease and selenium content of soil and meadow hay in the region of Kars, Turkey. Veterinary Journal 2002; 163: 214-217. doi: 10.1053/tvjl.2001.0652.
• 31. Stabel JR, Spears JW, Brown TT, Brake J. Selenium effects on glutathione peroxidase and the immune response of stressed calves challenged with Pasteurella hemolytica. Journal of Animal Science 1989; 67:557-564. doi: 10.2527/jas1989.672557x.
• 32. Kachuee R, Moeini M, Souri M. Effects of organic and inorganic selenium supplementation during late pregnancy on colostrum and serum Se status, performance and passive immunity in Merghoz goats. Animal Production Science 2013; 54: 1016-1022. doi: 10.1071/AN13150.
• 33. Spears JW. Micronutrients and immune function in cattle. Proceedings of the Nutrition Society 2000; 59: 587-594. doi: 10.1017/s0029665100000835.
• 34. Chew BP. Immune function: relationship of nutrition and disease control. Vitamin A and beta-carotene on host defense. Journal of Dairy Science 1987; 70: 2732-2743. doi: 10.3168/jds.s0022-0302(87)80346-6.
• 35. Weitberg AB, Weitzman SA, Clark EP, Stossel TP. Effects of antioxidants on oxidant-induced sister chromatid exchange formation. The Journal of Clinical Investigation 1985; 75: 1835-1841. doi: 10.1172/JCI111897.
• 36. Omara EA, Nada SA, Zahran HG. Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride. The Egyptian Journal of Hospital Medicin 2009; 35: 295 - 308.
• 37. Michal JJ, Heirman LR, Wong TS, Chew BP, Frigg M, et al. Modulatory effects of dietary beta-carotene on blood and mammary leukocyte function in periparturient dairy cows. Journal of Dairy Science 1994; 77: 1408-1421. doi: 10.3168/jds.S0022-0302(94)77079-X.
• 38. Chattha KS, Kandasamy S, Vlasova AN, Saif LJ. Vitamin A deficiency impairs adaptive B and T cell responses to a prototype monovalent attenuated human rotavirus vaccine and virulent human rotavirus challenge in a gnotobiotic piglet model. PLoS One 2013; 8: e82966. doi: 10.1371/journal.pone.0082966.
• 39. Cen G, Luo P, Gao Y. Progress in Pharmacological Effects of Echinacea. Journal Drugs and Clinical 2010; 25:15-18. (In Chinese)
• 40. Uluisik D, Keskin E. Effects of ginseng and echinacea on cytokine mRNA expression in rats. The Scientific World Journal 2012; 2012: 942025. doi: 10.1100/2012/942025.
• 41. Ismael AB, El-Nabtity SM, Aly AA. Dramatic improvement in the efficacy of Foot and Mouth disease vaccines by co-administration of echinacea. Veterinary Medical Journal Giza 2009; 57: 1.
• 42. Guan Y, Chen J, Zhou S, Liu C, Guo S, et al. A randomized and controlled study of the effect of Echinacea Purpurea on canine Parvovirus and Distemper virus antibody levels in dogs. American Journal of Traditional Chinese Veterinary Medicine 2018; 13: 13-18.
• 43. Doaa FT, El-Saied UM, Sallam AA, El-Baz AM, Hussein AM. Effect of using Echinacea extract as immuno-stimulating additive on milk yield traits, immunity and udder health of Zaraibi goats. Egyptian Journal of Sheep and Goat Sciences 2009; 4: 33-53.
• 44. Brazao V, Filipin MDV, Santello FH, Azevedo AP, Toldo MPA, et al. Immunomodulatory properties and anti-apoptotic effects of zinc and melatonin in an experimental model of chronic Chagas disease. Immunobiology 2015; 220: 626-633. doi: 10.1016/j.imbio.2014.11.018.
• 45. Rosenkranz E, Maywald M, Hilgers RD, Brieger A, Clarner T, et al. Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration. The Journal of Nutritional Biochemistry 2016; 29: 116-123. doi: 10.1016/j.jnutbio.2015.11.010.
• 46. Abdullah KM, Basbugan Y. The effect of used immunostimulating drugs with FMD vaccine on immunoglobulins in sheep. Van Veterinary Journal 2020; 31: 15-21. doi: 10.36483/vanvetj.547457.
• 47. Rashid BM, Yuksek N. The Effects of Immunostimulants (Zinc, Levamisole, Vitamin AD3E) Use together with Enterotoxaemia vaccine on immunoglobulins in sheep. Turkish Journal of Veterinary Research 2019; 3: 57-65.
• 48. McFadden RA, Heinrich NA, Haarstad AC, Tomlinson DJ. A double-blinded, randomized, controlled, crossover evaluation of a zinc methionine supplement as an adjunctive treatment for canine atopic dermatitis. Veterinary Dermatology 2017; 28: 569-e138. doi: 10.1111/vde.12466.
• 49. Thienpont D, Vanparijs OF, Raeymaekers AH, Vandenberk J, Demoen JA, et al. Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature 1966; 209: 1084-1086. doi: 10.1038/2091084a0.
• 50. Chadwick RG, Jain S, Cohen BJ, Scott GM, Thomas HC, et al. Levamisole therapy for HBsAg-positive chronic liver disease. Scandinavian Journal of Gastroenterology 1980; 15: 973-978. doi: 10.3109/00365528009181800.
• 51. Spector S, Munjal I, Schmidt DE. Effects of the immunostimulant, levamisole, on opiate withdrawal and levels of endogenous opiate alkaloids and monoamine neurotransmitters in rat brain. Neuropsychopharmacology 1998; 19: 417-427. doi: 10.1016/S0893-133X(98)00034-7.
• 52. Szeto CC, Gillespie KM, Mathieson PW. Levamisole induces interleukin-18 and shifts type 1/type 2 cytokine balance in the immune response of experimentally malnourished rats. Immunology 2000; 100: 217-224. doi: 10.1046/j.1365-2567.2000.00042.x.
• 53. Undiandeye UJ, Oderinde BS, El-Yuguda A, Baba SS. Immunostimulatory effect of levamisole on the immune response of goats to peste des petits ruminants (PPR) vaccination. World Journal of Vaccines 2014; 4: 88-95.doi: 10.4236/wjv.2014.42011.
• 54. El-shahedy M, Fatah SA, Salem S, Gamal M. Immunostimulant activity of levamisole to polyvalent FMD vaccine in buffaloes. Suez Canal Veterinary Medical Journal 2015; 20: 449-461. doi: 10.21608/scvmj.2015.64651.
• 55. Aydin O. Küçük ruminant vebası (PPR) aşısı uygulanan morkaraman ırkı koyunlarda vitamin C, vitamin D, levamizol, parapoxvirüs ovis ve corynebacterium cutis lizatının immun sistem üzerine etkilerinin araştırılması, Doktora tezi, Atatürk Üniv Sağ Bil Ens, Erzurum 2020; s. 127. (thesis in Turkish with an English abstract).
• 56. Wang R, Luo S. Orf virus: a new class of immunotherapy drugs. Vlachakis D. eds. In: Systems Biology. IntechOpen, 2018; pp.45.
• 57. Friebe A, Siegling A, Friederichs S, Volk HD, Weber O. Immunomodulatory effects of inactivated parapoxvirus ovis (ORF virus) on human peripheral immune cells: induction of cytokine secretion in monocytes and Th1-like cells. Journal of Virology 2004; 78: 9400-9411. doi: 10.1128/JVI.78.17.9400-9411.2004.
• 58. Horohov DW, Breathnach CC, Sturgill TL, Rashid C, Stiltner JL, et al. In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis. Equine Veterinary Journal 2008; 40: 468-472. doi: 10.2746/042516408X322111.
• 59. Turk N, Župančić Ž, Starešina V, Kovač S, Babić T, et al. Severe bovine papillomatosis: detection of bovine papillomavirus in tumour tissue and efficacy of treatment using autogenous vaccine and parammunity inducer. Veterinarski Arhiv 2005; 75:391-397.
• 60. Ons E, Van Brussel L, Lane S, King V, Cullinane A, et al. Efficacy of a Parapoxvirus ovis-based immunomodulator against equine herpesvirus type 1 and Streptococcus equi equi infections in horses. Veterinary Microbiology 2014; 173: 232-240. doi: 10.1016/j.vetmic.2014.07.015. 61. Pekmezci D, Pekmezci GZ, Guzel M, Cenesiz S, Gurler AT, et al. Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalised demodicosis. Veterinary Record 2014; 174: 556. doi: 10.1136/vr.102226.
• 62. Hartmann K, Block A, Ferk G, Vollmar A, Goldberg M, et al.Treatment of feline leukemia virus-infected cats with paramunity inducer. Veterinary Immunology and Immunopathology 1998; 65 :267-275. doi: 10.1016/s0165-2427(98)00161-5.
• 63. Shalaby MA, Saleh SM, el-Atrash S, Sami AM, el-Sanousi AA et al. Application of Corynebacterium cutis lysate as an immune stimulant in cattle. Molecular Biotherapy 1992; 4: 147-150.
• 64. Yilmaz O, Kasikci G. Factors affecting colostrum quality of ewes and immunostimulation. Turkish Journal of Veterinary and Animal Sciences 2013; 37:390-394.doi: 10.3906/vet-1210-33.
• 65. Dik B, Dik I, Bahcivan E, Avci O. Corynebacterium cutis lysate treatment can increase the efficacies of PPR vaccine. Journal of Interferon Cytokine Research 2016; 36: 599-606. doi: 10.1089/jir.2016.0035.
• 66. Saat N, Yuksel M, Toraman ZA, Ri̇svanli̇ A. The efficiency of Corynebacterium cutis lysate in cows with subclinical mastitis. Research Opinions in Animal and Veterinary Sciences 2016; 6: 108-110.
• 67. Calik H. Buzağı ishallerine karşı aşılanan gebe düvelerde corynebacterium cutis lizatı’nın kolostrum immunglobulin G düzeylerine etkisi, Yüksek Lisans Tezi, Erciyes Üniv Sağ Bil Ens, Kayseri 2016; s. 24. (thesis in Turkish with an English abstract).