A CASE OF ACUTE LYMPHOBLASTIC LEUKEMIA IN A CAT

Yıl 2024, Cilt: 5 Sayı: 2, 76 - 84

Emre Tüfekçi , Gencay Ekinci , Mehmet Tuzcu , Vehbi Güneş , Alfatıh Mohammed Ahmed Abozaıd Alfatıh Mohammed Ahmed Abozaıd , Bünyamin Ersöz , Batuhan Bali , Celil Bendeş

https://doi.org/10.58833/bozokvetsci.1509814

Öz

Acute lymphoblastic leukemia (ALL) is a rare hematopoietic neoplasm in cats and dogs in which immature lymphoid progenitor cells clonally proliferate in the bone marrow. ALL is characterized by rapid progression and low response to treatment protocols. Chemotherapeutic drugs, steroidal anti-inflammatory drugs, and supportive care are used in the treatment. This study aimed to provide information about the cytology results, clinical process, and treatment protocol of ALL diagnosed in biopsy samples taken from the lymph nodes and peripheral blood smears of a cat with feline leukemia virus infection (FeLV). In addition, in this case report, biochemical changes such as hyperproteinemia, hyperalbuminemia, hypernatremia, and hyperkalemia during the disease process were determined and neurological signs such as keratitis, tongue paralysis and neurogenic bladder, which are not seen in FeLV-infected cats, were detected and reported. This hematopoietic disease, which is not frequently encountered in cats, was prepared with the belief that it would be useful to veterinarians and is the first report of acute lymphoblastic leukemia in cats in Türkiye.

Anahtar Kelimeler

FeLV, Acute Lymphoblastic Leukemias, Chemotherapy Treatment, Hematopoietic Neoplasm

BİR KEDİDE AKUT LENFOBLASTİK LÖSEMİ OLGUSU

Öz

Akut lenfoblastik lösemi (ALL), kedi ve köpeklerde olgunlaşmamış lenfoid progenitör hücrelerin kemik iliğinde klonal olarak çoğaldığı nadir bir hematopoetik neoplazmdır. ALL hızlı ilerleme ve tedavi protokollerine düşük yanıt ile karakterizedir. Tedavide kemoterapötik ilaçlar, steroid antiinflamatuar ilaçlar ve destekleyici bakım kullanılmaktadır. Bu çalışmada, kedi lösemi virüsü enfeksiyonu (FeLV) tanısı konulan bir kedinin lenf düğümlerinden alınan biyopsi örnekleri ve periferik kan smear örneklerinde teşhis edilen ALL'nin sitoloji sonuçları, klinik süreci ve tedavi protokolü hakkında bilgi verilmesi amaçlandı. Ayrıca bu olgu sunumunda hastalık sürecinde hiperproteinemi, hiperalbüminemi, hipernatremi ve hiperkalemi gibi biyokimyasal değişiklikler belirlenmiş ve FeLV ile enfekte kedilerde görülmeyen keratit, dil felci ve nörojenik mesane gibi nörolojik bulgular tespit edilerek raporlanmıştır. Kedilerde sık rastlanmayan bu hematopoietik hastalık, veteriner hekimlere faydalı olacağı düşüncesiyle hazırlanmış olup, Türkiye'de kedilerde akut lenfoblastik löseminin ilk raporudur.

Anahtar Kelimeler

FeLV, Akut Lenfoblastik Lösemi, Kemoterapi Tedavisi, Hematopoietik Neoplazm

Kaynakça

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