INVESTIGATION OF ZONULIN LEVELS IN DOGS INFECTED WITH CANINE DISTEMPER VIRUS

Yıl 2024, Cilt: 5 Sayı: 2, 55 - 61

Ethem Mert Çöllü , Tahir Özalp , Songül Erdoğan , Kerem Ural , Hasan Erdoğan

https://doi.org/10.58833/bozokvetsci.1545898

Öz

This study aims to investigate the impact of Canine Distemper Virus (CDV) infection on plasma zonulin levels, focusing particularly on how this effect varies in patients exhibiting neurological symptoms. The research involved the evaluation of 20 infected dogs and 10 healthy control dogs, all of which were brought to the Internal Medicine Clinics of Aydın Adnan Menderes University Veterinary Faculty for diagnosis and treatment. The zonulin levels in the infected dogs were found to be significantly higher compared to the healthy controls. These findings suggest that the virus affects not only the gastrointestinal barrier but also the blood-brain barrier. This supports the hypothesis that these changes may contribute to the increased permeability of the blood-brain barrier.

Anahtar Kelimeler

Distemper, Dog, Gut permeability, Zonulin

Proje Numarası

This study was supported by the Scientific Research Projects Unit of Aydın Adnan Menderes University under project number VTF – 23022.

KANİN DİSTEMPER VİRUS İLE ENFEKTE KÖPEKLERDE ZONULİN SEVİYELERİNİN ARAŞTIRILMASI

Öz

Bu çalışma, Canine Distemper Virüs (CDV) enfeksiyonunun plazma zonulin seviyeleri üzerindeki etkisini, özellikle nörolojik semptomlar gösteren hastalarda nasıl değiştiğini araştırmayı amaçlamaktadır. Araştırmada, Aydın Adnan Menderes Üniversitesi Veteriner Fakültesi İç Hastalıkları Klinikleri’ ne tanı ve tedavi için getirilen 20 enfekte köpek ve 10 sağlıklı kontrol köpeği değerlendirilmiştir. Enfekte köpeklerde zonulin seviyeleri, sağlıklı kontrollerden anlamlı derecede yüksek bulunmuştur. Bu bulgular, virüsün sadece gastrointestinal bariyeri değil, aynı zamanda kan-beyin bariyerini de etkilediğini önermektedir. Bu değişikliklerin kan-beyin bariyerinin artan geçirgenliğine katkıda bulunabileceği hipotezini desteklemektedir.

Anahtar Kelimeler

Bağırsak geçirgenliği, Distemper, Köpek, Zonulin.

Etik Beyan

adü hadyek 64583101/2022/74

Destekleyen Kurum

This study was supported by the Scientific Research Projects Unit of Aydın Adnan Menderes University under project number VTF – 23022.

Proje Numarası

This study was supported by the Scientific Research Projects Unit of Aydın Adnan Menderes University under project number VTF – 23022.

Kaynakça

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