A Systematic Journey on the Naturally-Occurring Red Pigment Lycopene and Its Beneficial Effects on Health

Yıl 2024, , 139 - 154, 15.01.2024

Güney Akınoğlu , Arzu Erdal

https://doi.org/10.34248/bsengineering.1329375

Cited By: 1

Öz

Lycopene is a red pigment that belongs to the carotenoid group and occurs naturally in some vegetables and fruits, especially tomatoes and tomato-derived foods. The lycopene pigment is considered a powerful antioxidant and a carotenoid that has no pro-vitamin A activity. Lycopene has unique structural and chemical properties that can contribute to specific biological properties. Lycopene is thought to have a variety of beneficial effects in the prevention and treatment of various diseases such as diabetes, cardiovascular disease, cancer, skin and bone disorders, and neurological disorders. Although information is gradually accumulating in the literature on the bioavailability, tissue distribution, metabolism, excretion, and biological effects of lycopene in experimental animals and humans, further research is needed. This review summarizes the current state of knowledge on the properties, sources, absorption and bioavailability of lycopene and its potential role in human health.

Anahtar Kelimeler

Lycopene, Carotenoid, Tomato, Antioxidant, Human health

Doğal Olarak Bulunan Kırmızı Pigment Likopen Ve Sağlığa Faydalı Etkileri Üzerine Sistematik Bir Yolculuk

Öz

Likopen, başta domates ve domates türevi gıdalar olmak üzere bazı sebze ve meyvelerde doğal olarak bulunan, karotenoidler grubuna ait kırmızı renkli bir pigmenttir. Likopen pigmenti, güçlü bir antioksidan ve pro-vitamin A aktivitesi göstermeyen bir karotenoid olarak kabul edilir. Likopen, spesifik biyolojik özelliklere katkıda bulunabilecek benzersiz yapısal ve kimyasal özelliklere sahiptir. Diyabet, kardiyovasküler hastalıklar, kanserler, cilt ve kemik rahatsızlıkları, nörolojik bozukluklar gibi çeşitli hastalıkların önlenmesi ve tedavisinde likopenin çok çeşitli yararlı etkilere sahip olduğu bildirilmiştir. Deney hayvanlarında ve insanlarda likopenin biyoyararlanımı, dokularda dağılımı, metabolizması, atılımı ve biyolojik etkileri ile ilgili bilgiler literatürde birikmeye başlasa da bu konuda daha fazla araştırma yapılması gerekmektedir. Bu derleme, likopenin özellikleri, likopen kaynakları, alınımı ve biyoyararlanımı ile birlikte insan sağlığındaki olası rolü hakkındaki mevcut bilgi durumunu özetlemektedir.

Anahtar Kelimeler

Likopen, Karotenoid, Domates, Antioksidan, İnsan sağlığı

Kaynakça

• Aberoumand A. 2011. A review article on edible pigments properties and sources as natural biocolourants in foodstuff and food industry. World J Dairy Food Sci, 6: 71-78.
• Agcam E, Akyıldız A, Balasubramaniam VM. 2017. Optimization of anthocyanins extraction from black carrot pomace with thermosonication. Food Chem, 237: 461-470.
• Akhtar MS, Goldschmidt EE, John I, Rodoni S, Matile P, Grieson D. 1999. Altered patterns of senescence and ripening in gf, a stay-green mutant of tomato (Lycopersicon esculentum Mill.). J Exp Bot, 50: 1115-1122.
• Akınoğlu G, Korkmaz A. 2016. Topraksız tarımda farklı substrat miktarı ve besin çözeltisi uygulamalarının domateste beslenme ve verim kriterlerine etkisi. Toprak Bilimi ve Bitki Besleme Dergisi, 4: 49-56.
• Alda LM, Gogoaşă L, Bordean D-M, Gergen I, Alda S, Moldovan C, Niţă L. 2009. Lycopene content of tomatoes and tomato products. J Agroaliment Process Technol, 15: 540-2.
• Allen CM, Smith AM, Clinton SK, Schwartz SJ. 2002. Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women. J Am Diet Assoc, 102: 1257-62.
• Al-Wandawi H, Abdul-Rahman M, AlShaikhly K. 1985. Tomato processing waste as essential raw materials source. J Agric Food Chem, 33: 804-807.
• Arain MA, Mei Z, Hassan FU. Saeed M, Alagawany M, Shar AH, Rajput IR. 2018. Lycopene: a natural antioxidant for prevention of heat-induced oxidative stress in poultry. Worlds Poult Sci J, 74: 89-100.
• Ascenso A, Pedrosa T, Pinho S, Pinho F, de Oliveira JM, Cabral Marques H, Oliveira H, Simões S, Santos C. 2016. The effect of lycopene preexposure on UV-B-irradiated human keratinocytes. Oxid Med Cell Longev, 2016: 8214631.
• Ascenso A, Pinho S, Eleutério C, Praça F, Lopes Badra Bentley MV, Oliveira H, Santos C, Simões S. 2013. Lycopene from tomatoes: Vesicular nanocarrier formulations for dermal delivery. J Agric Food Chem, 61: 7284-7293.
• Ascenso A. 2012. Carrier-mediated dermal delivery for prevention or treatment of skin disorders.
• Awolu OO, Oladeji OA. 2021. Natural plant pigments and derivatives in functional foods developments. EJFST, 5: 25-40.
• Aydemir G, Kasiri Y, Birta E, Béke G, Garcia AL, Bartók EM, Rühl R. 2013. Lycopene-derived bioactive retinoic acid receptors/retinoid-X receptors-activating metabolites may be relevant for lycopene’s anti-cancer potential. Mol Nutr Food Res, 57: 739-747.
• Bacanli M, Başaran N, Başaran AA. 2017. Lycopene: Is it beneficial to human health as an antioxidant? Turk J Pharm Sci, 14: 311-318
• Baldermann S, Ropeter K, Kohler N, Fleischmann P. 2008. Isolation of all-trans lycopene by high-speed counter-current chromatography using a temperature-controlled solvent system. J Chromatogr A, 1192: 191-193.
• Boileau TWM, Boileau AC, Erdman JW Jr. 2002. Bioavailability of all-trans and cis-isomers of lycopene. Exp Biol Med (Maywood), 227: 914-19.
• Borel P, Moussa M, Reboul E, Lyan B, Defoort C, Vincent-Baudry S, Maillot M, Gastaldi M, Darmon M, Portugal H, Planells R, Lairon D. 2007. Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism. J Nutr, 137: 2653-2659.
• Bouvier F, Backhaus RA, Camara B. 1998. Induction and control of chromoplastspecific carotenoid genes by oxidative stress. J Biol Chem, 273: 30651-30659.
• Brown MJ, Ferruzzi MG, Nguyen ML, Cooper DA, Eldridge AL, Schwartz SJ, White WS. 2004. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressing as measured with electrochemical detection. Am J Clin Nutr, 80: 396-403.
• Buggy MJ, Britton G, Goodwin TW. 1969. Stereo-chemistry of phytoene biosynthesis by isolated chloroplasts. Biochem J, 114: 641-643.
• Burton GW, Ingold KU. 1984. β-carotene: an unusual type of lipid antioxidant. Science, 224: 569-573.
• Campos KKD, Araújo GR, Martins TL, Bandeira ACB, Costa GP, Talvani A, Garcia CCM, Oliveira LAM, Costa DC, Bezerra FS. 2017. The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke. J Nutr Biochem, 48: 9-20.
• Caseiro M, Ascenso A, Costa A, Creagh-Flynn J, Johnson M, Simões S. 2020. Lycopen and Human Health. LWT - Food Sci Technol, 127: 109323
• Cassileth B. 2010. Lycopene. Oncology, 24: 296.
• Choudhary R, Bowser TJ, Weckler P, Maness NO, McGlynn W. 2009. Rapid estimation of lycopene concentration in watermelon and tomato puree by fiber optic visible reflectance spectroscopy. Postharvest Biol Technol, 52: 103-109.
• Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr. 1996. Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev, 5: 823-833.
• Clinton SK. 1998. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev, 56: 35-51.
• Conn PF, Lambert C, Land EJ, Schalch W, Truscott TG. 1992. Carotene-oxygen radical interactions. Free Radic Res Commun, 16: 401-408.
• Conn PF, Schalch W, Truscott TG. 1991. The singlet oxygen andcarotenoid interaction. J Photochem Photobiol B Biol, 11: 41-47.
• Corridan B, O’Donohue M, Morrissey P. 1998. Proceedings of Proceedings-Nutrition Society of London. Cambridge University Press; Cambridge, UK: Carotenoids and immune response in elderly people; p. 4A.
• Cramer DW, Kuper H, Harlow BL, Titus-Ernstoff L. 2001. Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women. Int J Cancer, 94: 128-134.
• Crupi P, Faienza MF, Naeem MY, Corbo F, Clodoveo ML, Muraglia M. 2023. Overview of the potential beneficial effects of carotenoids on consumer health and well-being. Antioxidants, 12: 1069.
• D’Souza MC, Singha S, Ingle M. 1992. Lycopene concentration of tomato fruit can be estimated from chromaticity values. HortScience, 27: 465-466.
• Davis AR, Fish WW, Perkins-Veazie P. 2003. A rapid spectrophotometric method for analyzing lycopene content in tomato and tomato products. Postharvest Biol Technol, 28: 425-430.
• De Nardo T, Shiroma-Kian C, Halim Y, Francis D, Rodrigues-Saona LE. 2009. Rapid and simultaneous determination of lycopene and β-carotene contents in tomato juice by infrared spectroscopy. J Agric Food Chem, 57: 1105-1112.
• Dey S, Bommu Hema Nagababu BH. 2022. Applications of food color and bio-preservatives in the food and its effect on the human health. Food Chem Adv, 1: 100019.
• Di Mascio P, Kaiser S, Sies H. 1989. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys, 274: 532-538.
• Di Mascio P, Murphy ME, Sies H. 1991. Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 53: 194S-200S.
• Dias IHK, Polidori MC, Lietal L. 2014. Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities. J Alzheimer’s Dis, 40: 399-408.
• Diwadkar-Navsariwala V, Novotny J, Gustin DM, Sosman JA, Rodvold KA, Crowell JA, Stacewicz-Sapuntzakis M, Bowen PE. 2003. A physiological pharmacokinetic model describing the disposition of lycopene in healthy men. J Lipid Res, 44: 1927-39
• Durairajanayagam D, Agarwal A, Ong C, Prashast P. 2014. Lycopene and male infertility. Asian J Androl, 16: 420-425.
• During A, Dawson HD, Harrison EH. 2005. Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in caco-2 cells treated with ezetimibe. J Nutr, 135: 2305-12.
• During A, Harrison EH. 2004. Intestinal absorption and metabolism of carotenoids: insights from cell culture. Arch Biochem Biophys, 430: 77-88.
• Elvira-Torales LI, García-Alonso J, Periago-Castón MJ. 2019. Nutritional importance of carotenoids and their effect on liver health: A review. Antioxidants (Basel), 8, 229
• Etminan M, Takkouche B, Caamaño-Isorna F. 2004. The role of tomato products and lycopene in the prevention of prostate cancer: A meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev, 13: 340-345.
• Fabian E, Elmadfa I. 2007. The effect of daily consumption of probiotic and conventional yoghurt on oxidant and anti-oxidant parameters in plasma of young healthy women. Int J Vitam Nutr Res, 77: 79-88.
• Failla ML, Chitchumroonchokchai C, Ishida BK. 2008. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. J Nutr, 138: 482-86.
• Faria-Silva C, Ascenso A, Costa AM, Marto J, Carvalheiro M, Ribeiro HM, Simões S. 2020. Feeding the skin: A new trend in food and cosmetics convergence. Trends Food Sci Technol, 95: 21-32.
• Foote CS, Denny RW. 1968. Chemistry of singlet oxygen. VII. Quenching by β-caotene. J Am Chem Soc, 90: 6233-6235.
• Frenkel C, Garrison SA. 1976. Initiation of lycopene synthesis in the tomato mutant rin influenced by oxygen and ethylene interaction. HortScience, 11: 20-21.
• Furr HC, Clark RM. 1997. Intestinal absorption and tissue distribution of carotenoids. J Nutr Biochem, 8: 364-77.
• Gao Q, Zhong C, Zhou X, Chen R, Xiong T, Hong M, Li Q, Kong M, Han W, Sun G, Yang X, Yang N, Hao L. 2019. The association between intake of dietary lycopene and other carotenoids and gestational diabetes mellitus risk during mid-trimester: A cross-sectional study. Br J Nutr, 121: 1405-1412.
• Gärtner C, Stahl W, Sies H. 1997. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr, 66: 116-22.
• Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. 1995. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst, 87: 1767-1776.
• Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC. 2002. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst, 94: 391-398.
• Gould WV. 1992. Tomato Production, Processing, and Technology, CTI Publications, Baltimore, USA.
• Grabowska M, Wawrzyniak D, Rolle K, Chomczyński P, Oziewicz S, Jurga S, Barciszewski J 2019. Let food be your medicine: Nutraceutical properties of lycopene. Food Funct, 10: 3090-3102.
• Gross J. 1987. Pigments in Fruits, Academic Press, Orlando.
• Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J. 2019. Tomato phytonutrients balance UV response: Results from a double-blind, randomized, placebo-controlled study. Skin Pharmacol Physiol, 32: 101-108.
• Harris WM. 1970. Chromoplasts of tomato fruits. III. The high-delta tomato. Bot Gaz, 131: 163-166.
• Hart DJ, Scott KJ. 1995. Development and evaluation of an HPLC method for the analysis of carotenoids in foods, and the measurement of the carotenoid content of vegetables and fruits commonly consumed in the UK. Food Chem, 54: 101-111.
• Heinonen MI, Ollilainen V, Linkola EK, Varo PT, Koivistoinen PE. 1989. Carotenoids in Finnish foods, vegetables, fruits, and berries. J Agric Food Chem, 37: 655-659.
• Hiragun M, Hiragun T, Oseto I, Uchida K, Yanase Y, Tanaka A, Okame T, Ishikawa S, Mihara S, Hide M. 2016. Oral administration of β-carotene or lycopene prevents atopic dermatitis-like dermatitis in HR-1 mice. J Dermatol, 43: 1188-1192.
• Holick CN, Michaud DS, Stolzenberg-Solomon R, Mayne ST, Pietinen P, Taylor PR, Virtamo J, Albanes D. 2002. Dietary carotenoids, serum β-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. Am J Epidemiol, 156: 536-547.
• Hossain B, Kamrul N, Biswas B. 2019. Studies of the compositional characteristics of commercial roasted beet root chips snacks. J Eng Res Rep, 4: 1-8.
• Hyman JR, Gaus J, Foolad MR. 2004. A rapid and accurate method for estimating tomato lycopene content by measuring chromaticity values of fruit puree. J Am Soc Hortic Sci, 129: 717-723.
• Ishida BK, Chapman MH. 2009. Carotenoid extraction from plants using a novel, environmentally friendly solvent. J Agric Food Chem, 57: 1051-1059.
• Ito Y, Kurata M, Hioki R, Suzuki K, Ochiai J, Aoki K. 2005. Cancer mortality and serum levels of carotenoids, retinol, and tocopherol: A population-based followup study of inhabitants of a rural area of Japan. APJCP, 6: 10-15.
• İzgi C. 2012. Farklı Kurutma Metotlarının Domatesteki Likopen Miktarına Etkisi. Yüksek Lisans Tezi, Namık Kemal Üniversitesi, Fen Bilimleri Enstitüsü, Tekirdağ, pp: 59.
• Jaswir I, Noviendri D, Hasrini RF, Octavianti F. 2011. Carotenoids: Sources, medicinal properties and their application in food and nutraceutical industry. J Med Plant Res, 5: 7119-7131.
• Jeffery D, Smith C, Goodenough P, Prosser I, Grierson D. 1984. Ethyleneindepent and ethylene-depent biochemical changes in ripening tomatoes. Plant. Physiol, 74: 32-38.
• Johnson EJ, Qin J, Krinsky NI, Russell RM. 1997. Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene. J Nutr, 127: 1833-37.
• Jonker D, Kuper CF, Fraile N, Estrella A, Rodríguez Otero C. 2003. Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regul Toxicol Pharmacol, 37: 396-406.
• Karrer P, Jucker E. 1950. Carotenoids. Elsevier, New York, USA, pp: 1950.
• Kaur G, Sandal A, Dhillon NS. 2017. Lycopene and human health-A review. Agricultural Reviews, 38: 282-289.
• Kaur H, Chauhan S, Sandhir R. 2011. Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson’s disease. Neurochem Res, 36: 1435-1443.
• Kelkel M, Schumacher M, Dicato M, Diederich M. 2011. Antioxidant and antiproliferative properties of lycopene. Free Radic Res, 45: 925-940.
• Khan U.M, Sevindik M, Zarrabi A, Nami M, Ozdemir B, Kaplan DN, Selamoglu Z, Hasan M, Kumar M, Alshehri MM, Sharifi-Rad J. 2021. Lycopene: Food Sources, Biological Activities, and Human Health Benefits. Oxid Med Cell Longev, 2021: 2713511.
• Khiveh A, Hashempur MH, Shakiba M, Lotfi MH, Shakeri A, Kazemeini S, Mousavi Z, Jabbari M, Kamalinejad M, Emtiazy M. 2017. Effects of rhubarb (Rheum ribes L.) syrup on dysenteric diarrhea in children: A randomized, double-blind, placebo-controlled trial. J Integr Med, 15: 365-372.
• Khudairi AK. 1972. The ripening of tomatoes. Am Sci, 60: 696-707.
• Kim JY, Lee JS, Han YS, Lee J.H, Bae I, Yoon YM, Kwon SM, Lee SH. 2015. Pretreatment with lycopene attenuates oxidative stress-induced apoptosis in human mesenchymal stem cells. Biomol Ther (Seoul), 23: 517-524.
• Kong KW, Khoo HE, Prasad KN, Ismail A, Tan CP, Rajab NF. 2010. Revealing the power of the natural red pigment lycopene. Molecules, 15: 959-987.
• Krinsky NI, Beecher G, Burk R, Chan A, Erdman JJ, Jacob R, Jialal I, Kolonel L, Marshall J, Taylor Mayne PR. 2000. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: The National Academies Press, doi: 10.17226/9810.
• Krinsky NI, Russett MD, Handeman GJ, Snodderly DM. 1990. Structural and germetrical isomers of carotenoids in human plasma. J Nutr, 120: 1654-1662.
• Kristal AR, Arnold KB, Schenk JM, Neuhouser ML, Goodman P, Penson DF, Thompson IM, 2008. Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: Results from the prostate cancer prevention trial. Am J Epidemiol, 167: 925-934.
• Kun Y, Lule US, Xiao-Lin D. 2006. Lycopene: its properties and relationship to human health. Food Rev Intr, 22: 309-33
• Kune G, Watson L. 2006. Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins B6, B12, C, E, selenium, and lycopene. Nutr Cancer, 56: 11-21.
• Kurt H. 2003. Sıçanlarda Karbon Tetraklorit’in (CCl4) Oluşturduğu Oksidatif Stresin Kateşin ve Likopen İle Önlenmesi, Doktora Tezi, Eskişehir Osmangazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Eskişehir.
• Kurzeja E, Stec M, Kościolek A, Wardas M, Pawłowska-Góral K. 2009. Biological activity of lycopene, Farm PrzeglNauk, 10: 17-19.
• Lademann J, Meinke MC, Sterry W, Darvin ME. 2011. Carotenoids in human skin. Exp Dermatol, 20: 377-382.
• Lampe C, Watada AE. 1971. Postharvest quality of high pigment and crimson tomato fruit. J. Am Soc Hort Sci, 96: 534-535.
• Laval-Martin D. 1974. La maturation du fruit de tomato cerise: Mise en evidence, par cryodecapage, de l’evolution des chloroplastes en deux types de chromoplastes. Protoplasma, 82: 33-59.
• Lee MT, Chen BH. 2002. Stability of lycopene during heating and illumination in a model system. Food Chem, 78: 425-432.
• Lopes LB, Reed R. 2009. A simple and rapid method to assess lycopene in multiple layers of skin samples. Biomed Chromatogr, 24: 154-159.
• Lopes LB, VanDewall H, Li HT, Venugopal V, Li HK, Naydin S, Hosmer J, Levendusky M, Zheng H, Bentley MV, Levin R, Hass MA. 2010. Topical delivery of lycopene using microemulsions: Enhanced skin penetration and tissue antioxidant activity. J Pharm Sci, 99: 1346-1357.
• Lucarini M, Lanzi S, D’Evoli L, Aguizzi A, Lombardi-Boccia G. 2006. Intake of vitamin A and carotenoids from the Italian population–results of an Italian total diet study. Int J Vitam Nutr Res, 76: 103-9.
• Lucas R, Mihály J, Lowe GM, Graham DL, Szklenar M, Szegedi A, Töröcsik D, Rühl R. 2018. Reduced carotenoid and retinoid concentrations and altered lycopene isomer ratio in plasma of atopic dermatitis patients. Nutrients, 10: 1390.
• Lurie S, Handros A, Fallik E, Shapira. 1996. Reversible inhibition of tomato fruit gene expression at high temperature. Plant Physiol, 110: 1207-1214.
• Maoka T. 2020. Carotenoids as natural functional pigments. J Nat Med, 74: 1-16.
• Mares-Perlman JA, Brady WE, Klein R, Klein BEK, Bowen P, Stacewicz-Sapuntzakis M, Palta M. 1995. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch of Ophthalmol, 113: 1518-1523.
• Martínez A, Melendez-Martínez AJ. 2016. Lycopene, oxidative cleavage derivatives and antiradical activity. Comput Theor Chem, 1077: 92-98.
• Matienco BT, Yedalty EM. 1973. Ultrastructure of Carotenoidoplasts, Academic Press, New York. NY, USA
• McGill AEJ. 2009. The potential effects of demands for natural and safe foods on global food security. Trends Food Sci Technol, 20: 402-406.
• Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-Evans CA. 1996. Antioxidant activities of carotenes and xanthophylls. FEBS Lett, 384: 240-242.
• Mohr WP. 1979. Pigment bodies in fruits of crimson and high pigment lines of tomatoes. Ann Bot, 44: 427-434.
• Moran NE, Erdman JW, Clinton SK. 2013. Complex interactions between dietary and genetic factors impact lycopene metabolism and distribution. Arch Biochem Biophys, 539: 171-80.
• Moussa M, Landrier J, Reboul E, Ghiringhelli O, Comera C, Collet X, Fröhlich K, Böhm V, Borel P. 2008. Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. J Nutr, 138: 1432-36.
• Najafi A, Taheri RA, Mehdipour M, Farnoosh G, Martínez-Pastor F. 2018. Lycopene-loaded nanoliposomes improve the performance of a modified Beltsville extender broiler breeder roosters. Anim Reprod Sci, 195: 168-175.
• Narciso Tomé AM. 2014. O Licopeno na prevenção do envelhecimento cutâneo - Ficção ou realidade. Faculdade de Farmácia da Universidade de Lisboa.
• Nguyen ML, Francis D, Schwartz SJ. 2001. Thermal isomerisation susceptibility of carotenoids in different tomato varieties. J Sci Food Agric, 81: 910-17.
• Nguyen ML, Schwartz SJ. 1998. Lycopene stability during food processing. Proc Soc Exp Biol Med, 218: 101-5.
• Nishino M, Miuchi T, Sakata M, Nishida A, Murata Y, Nakamura Y. 2011. Photostability of lycopene dispersed in an aqueous solution. Biosci Biotechnol Biochem, 75: 1389-1391.
• Nkondjock A, Ghadirian P, Johnson KC, Krewski D. 2005. Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J Nutr, 135: 592-597.
• Orgeron R II, Pope J, Green V, Erickson D. 2019. Phytonutrient intake and body composition: Considering colors. FFHD, 9: 108-122.
• Palozza P, Parrone N, Catalano A, Simone R. 2010. Tomato lycopene and inflammatory cascade: Basic interactions and clinical implications. Curr Med Chem, 17: 2547-2563.
• Palozza P. 1998. Prooxidant actions of carotenoids in biologic systems. Nutr Rev, 56: 257-265.
• Pan WH, Yeh NH, Yang RY, Lin WH, Wu WC, Yeh WT, Sung MK, Lee HS, Chang SJ, Huang CJ, Lin BF, Chiang MT. 2018. Vegetable, fruit, and phytonutrient consumption patterns in Taiwan. J Food Drug Anal, 2: 145-153.
• Parada J, Aguilera JM 2007. Food microstructure affects the bioavailability of several nutrients. J Food Sci, 72: R21-32.
• Petropoulos SA, Sampaio SL, Gioia FD, Tzortzakis N, Rouphael Y, Kyriacou MC, Ferreira I. 2019. Grown to be blue- Antioxidants properties and health effects of coloured vegetables. Part I: Root vegetables. Antioxidants, 8: 617.
• Porrini M, Riso P. 2005. What are typical lycopene intakes? J Nutr, 135: 2042S-45S.
• Porter JW, Anderson DG. 1967. Biosynthesis of carotenoids. Ann Rev Plant Physiol, 18: 197-228.
• Prakash A, Kumar A. 2013. Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: An evidence of nitric oxide signaling. Eur J Pharmacol, 721: 373-381.
• Qu M, Nan X, Gao Z, Guo B, Liu B, Chen Z. 2013. Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons. Brain Res, 1540: 92-102.
• Qu M, Zhou Z, Chen C, Li M, Pei L, Chu F, Yang J, Wang Y, Li L, Liu C, Zhang L, Zhang G, Yu Z, Wang D. 2011. Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway. Neurochem Int, 59: 1095-1103.
• Rao AV, Argawal S. 1999. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review. Nutr Res, 19: 305-323.
• Rao AV, Waseem Z, Agarwal S. 1998. Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene. Food Res Intern, 31: 737-41.
• Reich P, Shwachman H, Craig JM. 1960. Lycopenemia: A variant of carotenemia. N Engl J Med, 262: 263-269.
• Rodriguez-Amaya DB. 2001. A Guide to Carotenoid Analysis in Foods; ILSI Press: Washington, USA, pp: 1-45.
• Rodriguez-Amaya DB, Kimura M. 2004. Carotenoids in foods. In Harvestplus Handbook for Carotenoid Analysis; IFPRI and CIAT: Washington, DC, USA, pp: 2-7.
• Sabbağ Ç, Sürücüoğlu MS. 2011. Likopen: İnsan sağlığında vazgeçilmez bir bileşen. Gıda Teknolojileri Elektronik Dergisi, 6: 27-41.
• Sachdeva AK, Chopra K. 2015. Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease. J Nutr Biochem, 26: 736-744.
• Sahin K, Orhan C, Sahin N, Küçük O. 2019. Anticancer Properties of Lycopene. In: Mérillon JM, Ramawat K. Editors. Bioactive molecules in food. reference series in phytochemistry. Springer, London, UK, pp: 935-969.
• Sahin K, Yenice E, Tuzcu M, Orhan C, Mizrak C, Ozercan IH, Sahin N, Yilmaz B, Bilir B, Ozpolat B, Kucuk O. 2018. Lycopene protects against spontaneous ovarian cancer formation in laying hens. J Cancer Prev, 23: 25-36.
• Saini RK, Rengasamy KR, Mahomoodally FM, Keum Y-S. 2020. Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives. Pharmacol Res, 155: 104730.
• Saltveit ME, Mencarelli F. 1988. Inhibition of ethylene synthesis and action in ripening tomato fruit by ethanol vapors. J Am Soc Hort Sci, 113: 572-576.
• Schierle J, Bretzel W, Buhler I, Faccin N, Hess D, Steiner K, Schuep W. 1996. Content and isomeric ratio of lycopene in food and human blood plasma. Food Chem, 59: 459-465.
• Schunck CA. 1903. The xanthophyll group of yellow colouring matters. Proc R Soc London, 72: 165-176.
• Selgas MD, Garcνa ML, Calvo MM. 2009. Effects of irradiation and storage on the physico-chemical and sensory properties of hamburgers enriched with lycopene. International J Food Sci Technol, 44: 1983-1989.
• Shah H, Mahajan SR. 2014. Screening of topical gel containing lycopene and dexamethasone against UV radiation induced photoaging in mice. Biomed Aging Pathol, 4: 303-308.
• Shakeri A, Hashempur MH, Mojibian M, Aliasl F, Bioos S, Nejatbakhsh F. 2018. A comparative study of ranitidine and quince (Cydonia oblonga Mill) sauce on gastroesophageal reflux disease (GERD) in pregnancy: A randomised, open-label, active-controlled clinical trial. J Obstet Gynaecol, 38: 899-905.
• Sharma SK, Le Maguer M. 1996. Lycopene in tomatoes and tomato pulp fractions. Ital J Food Sci, 2: 107-113.
• Sheehy RE, Kramer M, Hiatt W. 1988. Reduction of polygalacturonase activity in tomato fruit by antisense RNA. Proc Natl Acad Sci USA, 85: 8805-8809.
• Shi J, Le Maguer M. 2010. Lycopene in Tomatoes: Chemical and Physical. Crit Rev Food Sci Nutr, 40: 1-42.
• Shi, J, Le Maguer M, Bryan M. 2002. Lycopene from tomatoes. In Shi J, Mazza G, Le Maguer M, editors. Functional foods-biochemical and processing aspects. CRC Press, New York, USA, pp: 135-168.
• Shoji T. 2007. Polyphenols as natural food pigments: changes during food processing. Am J Food Technol, 2: 570-581.
• Simpson DJ, Baqar MR, Lee TH. 1977. Chemical regulation of plastid development. III. Effect of light and CPTA on chromoplast ultrastructure and carotenoids of Capsicum annuum. Z Pflanzenphysiol, 82: 189-209
• Stah W, Sies H. 1996. Lycopene: A biologically important carotenoid for humans? Arch Biochem Biophys, 336: 1-9.
• Stahl W, Sies H. 1992. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr, 122: 2161-66.
• Stahl W, Sundquist AR, Hamusch M, Schwarz W, Sies H. 1993. Separation of β-catonene geometrical isomers in biological samples. Clin Chem, 39: 810-814.
• Story EN, Kopec RE, Schwartz SJ, Harris, GK. 2010. An update on the health effects of tomato lycopene. Annu Rev Food Sci Technol, 1: 189-210.
• Su Q, Rowley KG, Balazs NDH. 2002. Carotenoids: Separation methods applicable to biological samples, J Chromatogr B, 781: 393-418
• Tonucci LH, Holden JM, Beecher GR, Khachik F, Davis C.S, Mulokon G. 1995. Carotenoid content in thermally processed tomato-based food products. J Agric Food Chem, 43: 579-586.
• Trumbo P, Yates AA, Schlicker S, Poos M. 2001. Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Acad Nutr Diet, 101: 294.
• Trumbo PR. 2005. Are there adverse effects of lycopene exposure? J Nutr, 135: 2060s-2061s.
• Tyssandier V, Cardinault N, Caris-Veyrat C, Amiot MJ, Grolier P, Bouteloup C, Azais-Braesco V, Borel P. 2002. Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans. Am J Clin Nutr, 75: 526-34.
• Ukai N, Lu Y, Etoh H, Yagi A, Ina K, Oshima S, Ojima F, Sakamoto H, Ishiguro Y. 1994. Photosensitized oxygenation of lycopene. Biosci Biotechnol Biochem, 58: 1718-1719.
• Unlu NZ, Bohn T, Clinton SK, Schwartz SJ. 2005. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J Nutr, 135: 431-36.
• Unlu NZ, Bohn T, Francis D, Clinton SK, Schwartz SJ. 2007. Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-β-carotene varieties of tomatoes. J Agric Food Chem, 55: 1597-1603.
• Veeramachaneni S, Ausman LM, Choi SW, Russell RM, Wang XD. 2008. High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats. J Nutr, 138: 1329-1335.
• Wang X-D. 2004. Carotenoid Oxidative/Degradative Products and Their Biological Activities. Marcel Dekker; New York, NY, USA.
• Xianquan S, Shi J, Kakuda Y, Yueming J. 2005. Stability of lycopene during food processing and storage. J Med Food, 8: 413-22
• Xu F, Yuan QP, Dong HR. 2006. Determination of lycopene and beta-carotene by high-performance liquid chromatography using sudan I as internal standard. J Chromatogr B, 838: 44-49.
• Yılmaz T. 2011. Domates İşleme Atıklarından Ultrason Destekli Likopen Ekstraksiyonu İşleminin Optimizasyonu. Yüksek Lisans Tezi, Ege Üniversitesi, Fen Bilimleri Enstitüsü, İzmir, pp: 128.
• Zeng Z, He W, Jia Z, Hao S. 2017. Lycopene improves insulin sensitivity through inhibition of STAT3/Srebp-1c-mediated lipid accumulation and inflammation in mice fed a high-fat diet. Exp Clin Endocrinol Diabetes, 125: 610-617.
• Zengin F, Kurt Ş. 2018. Likopen ve likopenin insan sağlığı açısından önemi. ADYÜTAYAM, 6: 30-45.
• Zhang F, Fu Y, Zhou X, Pan W, Shi Y, Wang M, Zhang X, Qi D, Li L, Ma K, Tang R, Zheng K, Song Y. 2016. Depression-like behaviors and heme oxygenase-1 are regulated by lycopene in lipopolysaccharideinduced neuroinflammation. J Neuroimmunol, 298: 1-8.
• Zumbrunn A, Uebelhart P, Eugster CH. 1985. HPLC of carotenes with y-end groups and (Z)-configuration at terminal conjugated double bonds, isolation of (5Z)-lycopene from tomatoes. Helv Chim Acta, 68: 1540-1542.
• Zuorro A, Lavecchia R, Medici F, Piga L. 2012. Enzyme-assisted production of tomato seed oil enriched with lycopene from tomato pomace. Food Bioproc Technol, 6: 3499-3509.