Synthesis, Characterization and Antimicrobial Activity of Mixed-Ligand Metal Complexes of 4,4'-Bipyridine and Aniline-2,5-Disulfonic Acid

Yıl 2024, Cilt: 7 Sayı: 2, 67 - 78, 31.12.2024

Nurgün Büyükkıdan , Seher Kaya , Halil İlkimen , Aysel Gülbandılar

Öz

In this study, we prepared mixed-ligand Co(II) complex{[Co(ADSA)(BP)]n.2H2O, 1}, Ni(II) complex {[Ni(ADSA)(BP)]n, 2}, and Zn(II) complex {[Zn(ADSA)(BP)(H2O)2]n.3H2O, 3} of 4,4'-bipyridine (BP) with aniline-2,5-disulfonic acid (H2ADSA). The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics (Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole). Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.

Anahtar Kelimeler

4,4'-Bipyridine, Aniline-2,5-disulfonic acid, Metal complex, Antimicrobial activity

4,4'-Bipiridin ve Anilin-2,5-Disülfonik Asidin Karışık Ligandlı Metal Komplekslerinin Sentezi, Karakterizasyonu ve Antimikrobiyal Aktivitesi

Öz

Bu çalışmada 4,4'-bipiridin (BP) ve anilin-2,5-disülfonik asit (H2ADSA) ile karışık ligandlı Co(II) {[Co(ADSA)(BP)]n.2H2O, 1}, Ni(II) {[Ni(ADSA)(BP)]n, 2} ve Zn(II)) {[Zn(ADSA)(BP)(H2O)2]n.3H2O, 3} kompleksleri hazırladı. 1-3 Element analizi, AAS, TGA, IR, UV-Vis, molar iletkenlik ve manyetik duyarlılık teknikleri ile karakterize edildi. Ayrıca mikrodilüsyon yöntemi ile başlangıç maddeleri ve sentezlenen metal komplekslerinin aşağıdaki bakteriler ve mayaya karşı antibakteriyel ve antifungal aktivitelerini araştırmak için kullanıldı: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis ve Candida albicans. Antibakteriyel ve antifungal aktivite sonuçları antibiyotiklerle (Vankomisin, Levofloksasin, Sefepim, Kloramfenikol, Flukonazol ve Ketokonazol) karşılaştırıldı. Yapılan çalışmalar incelendiğinde, yeni oluşturulan bileşiklerin hem bakteri hem de maya enfeksiyonlarıyla mücadelede aktivite gösterdiği gözlenmiştir.

Anahtar Kelimeler

4,4'-Bipiridin, anilin-2,5-disülfonik asit, Metal kompleksi, Antimikrobiyal aktivite

Kaynakça

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