Proton Transfer Salt and Metal Complexes of 4,4'-Ethylenedipyridine and 2,3-Pyrazinedicarboxylic Acid: Synthesis, Structural Characterization and Biological Activity

Abstract

In this study, a new salt {(H2BPE)(PDA), 1} synthesized from 4,4’-ethylenedipyridine (BPE) with 2,3 pyrazinedicarboxylic acid (H2PDA) and its complexes Fe(III) {(H2BPE)[Fe2(PDA)(H2O)4]n, 2} and Ni(II) {[Ni(PDA)(BPE)2(H2O)2]n.H2O, 3}, were synthesized and defined by using 1H and 13C NMR, TG-DTA, IR, UV Vis, elemental analysis, magnetic susceptibility techniques. In addition, antibacterial and antifungal activities of starting materials and synthesized compounds against Candida albicans yeast and Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Listeria monocytogenes bacteria were investigated using the microdilution method and compared with existing antibiotics (Cefepime, Vancomycin, Levofloxacin and Fluconazole). Compounds 1-3 were observed to have activity against yeast and bacteria. In particular, compound 3 (7.80 µg/mL) against E. faecalis, compounds 3 (7.80 µg/mL) against B. subtilis bacteria, and compound 1 (15.60 µg/mL) against C. albicans yeast. showed better activity than control compounds.

Keywords

• 4,4’-Ethylene dipyridine
• 2,3-Pyrazine dicarboxylic acid
• Metal complex
• Antimicrobial activity

4,4'-Etilendipiridin ve 2,3-Pirazindikarboksilik Asidin Proton Transfer Tuzu ve Metal Kompleksleri: Sentez, Yapısal Karakterizasyon ve Biyolojik Aktivite

Öz

Bu çalışmada, 4,4'-etilendipiridin (BPE) ile 2,3-pirazindikarboksilik asit’in (H2PDA) yeni bir tuz {(H2BPE)(PDA), 1} ve tuzun Fe(III) {(H2BPE)Fe2(PDA)(H2O)4]n, 2} ve Ni(II) {[Ni(PDA)(BPE)2(H2O)2]n.H2O, 3} kompleksleri sentezlendi ve 1H ve 13C NMR TG-DTA, IR, UV-Vis, element analizi, manyetik duyarlılık teknikleri kullanılarak önerildi. Ayrıca başlangıç materyallerinin ve sentezlenen bileşiklerin Candida albicans mayası ve Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli ve Listeria monocytogenes bakterilerine karşı antibakteriyel ve antifungal aktiviteleri mikrodilüsyon yöntemi kullanılarak araştırılmış ve mevcut antibiyotiklerle (Cefepime, Vankomisin, Levofloksasin ve Flukonazol) kıyaslanmıştır. 1-3 Bileşiklerin maya ve bakterilere karşı aktiviteye sahip olduğu gözlendi. Özellikle, E. faecalis'e karşı bileşik 3 (7,80 µg/mL), B. subtilis bakterisine karşı bileşik 3 (7,80 µg/mL) ve C. albicans mayasına karşı bileşik 1 (15,60 µg/mL). kontrol bileşiklerinden daha iyi aktivite gösterdi.

Anahtar Kelimeler

• 4,4'-Etilenedipiridin
• 2,3-Pirazin dikarboksilik asit
• Metal kompleksi
• Antimikrobiyal aktivite

Kaynakça

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