Öz
Anahtar Kelimeler
Kaynakça
- C.Lu Frank, Jr.R.L.Sielken, ´Assessment of safety/risk of chemicals: inception and evolution of the ADI and dose response modeling procedures’, Toxicology Letters, 59(1991), pp.5-40.
- D.D.Boss, C.Brownie, ´Mixture Models for Continuous Data in Dose-Response Studies When Some Animals are Unaffected by Treatment’, Biometrics, 47(1991), pp.1489-1504.
- H.O.Hartley, Jr.R.L.Sielken, ´Estimation of “Safe Doses” in Carcinogenic Experiments’, Biometrics, 33(1977), pp.1-30.
- Jr.R.L.Sielken, ´Useful Tools for Evaluating and Presenting More Science in Quantitative Cancer Risk Assessments’, Toxic Substances Journal, 9(1989), pp.353-404.
- Jr.R.L.Sielken, ´Incorporating More Science into Cancer Dose-Response Extrapolations, Toxic Substances Journal, 11(1990), pp.87-94.
- J.Van Ryzin, K. Rai, The Use of Quantal Response Data to Make Predictions, in The Scientific Basis of Toxicity Assessment (New York: Elsevier North-Holland, 1979).
- L.J.Bain, M. Engelhardt, Statistical Analysis of Reliability and Life Testing Models Theory and Methods (New York: Marcel Dekker, inc, 1991).
- M.W. Anderson, D.G. Hoel, N.L.Kaplan, ´A General Scheme for the Incorporation of Pharmacokinetics in Low- Dose Risk Estimation for Chemical Carcinogenesis: Example-Vinly Chloride’, Toxicology and Applied Pharmacology, 55(1980), pp.154-161.
- M.D.Finkelstein, A.D.Schoenfeld, ´Analysis of Multiple Tumor Data from a Rodent Carcinogenicity Experiment’, Biometrics, 45(1989), pp.219-230.
- N.E. Day, ´The Armitage-Doll Multistage Model of Carcinogenesis’, Statistics of Medicine, 9(1990), pp.677-679.
- P.Armitage,´The Assessment of Low-Dose Carcinogenicity’, Biometrics, supplement (1982), pp.19-129.
- P.Armitage, R.Doll, ´A Two-Stage Theory of Carcinogenesis in relation to the age Distribution of Human Cancer’, British Journal of Cancer, 8(1957) pp.1-12. ¸» § ¸ T¹ 1© Tol(IJ)¼¹¹
Öz
Bu çalışmada, kanserojen ve toksik maddeler için, maruz kalınan veya idare edilen doz olarak daadlandırılan, güvenli dozu tahmin etmek için yeni bir model tanıtıldı. Bu model, aşağıda açıklanan varsayımıtemel almaktadır.Literatürde, bu konu için farklı varsayımlar kullanılarak elde edilen çeşitli modeller bulunmaktadır.Yukarıda tanımlanan varsayım altında bulunan model literatürde daha önce tanımlanan modellerden oldukçafarklıdır. Bulunan model ile maruz kalınan en güvenli doz ξ. için tahmin edici elde edilmiştir. Çalışmanınsonunda, simülasyon yolu ile elde edilen veriler modelimizde kullanlılarak optimum güvenli doz tahminedilmiştir
Anahtar Kelimeler
Güvenli Doz Doz Yanıt Modeli Yinelenen Weibull Süreci Tolerans
Kaynakça
- C.Lu Frank, Jr.R.L.Sielken, ´Assessment of safety/risk of chemicals: inception and evolution of the ADI and dose response modeling procedures’, Toxicology Letters, 59(1991), pp.5-40.
- D.D.Boss, C.Brownie, ´Mixture Models for Continuous Data in Dose-Response Studies When Some Animals are Unaffected by Treatment’, Biometrics, 47(1991), pp.1489-1504.
- H.O.Hartley, Jr.R.L.Sielken, ´Estimation of “Safe Doses” in Carcinogenic Experiments’, Biometrics, 33(1977), pp.1-30.
- Jr.R.L.Sielken, ´Useful Tools for Evaluating and Presenting More Science in Quantitative Cancer Risk Assessments’, Toxic Substances Journal, 9(1989), pp.353-404.
- Jr.R.L.Sielken, ´Incorporating More Science into Cancer Dose-Response Extrapolations, Toxic Substances Journal, 11(1990), pp.87-94.
- J.Van Ryzin, K. Rai, The Use of Quantal Response Data to Make Predictions, in The Scientific Basis of Toxicity Assessment (New York: Elsevier North-Holland, 1979).
- L.J.Bain, M. Engelhardt, Statistical Analysis of Reliability and Life Testing Models Theory and Methods (New York: Marcel Dekker, inc, 1991).
- M.W. Anderson, D.G. Hoel, N.L.Kaplan, ´A General Scheme for the Incorporation of Pharmacokinetics in Low- Dose Risk Estimation for Chemical Carcinogenesis: Example-Vinly Chloride’, Toxicology and Applied Pharmacology, 55(1980), pp.154-161.
- M.D.Finkelstein, A.D.Schoenfeld, ´Analysis of Multiple Tumor Data from a Rodent Carcinogenicity Experiment’, Biometrics, 45(1989), pp.219-230.
- N.E. Day, ´The Armitage-Doll Multistage Model of Carcinogenesis’, Statistics of Medicine, 9(1990), pp.677-679.
- P.Armitage,´The Assessment of Low-Dose Carcinogenicity’, Biometrics, supplement (1982), pp.19-129.
- P.Armitage, R.Doll, ´A Two-Stage Theory of Carcinogenesis in relation to the age Distribution of Human Cancer’, British Journal of Cancer, 8(1957) pp.1-12. ¸» § ¸ T¹ 1© Tol(IJ)¼¹¹
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Şubat 2005 |
| Yayımlandığı Sayı | Yıl 2005 Cilt: 1 Sayı: 4 |