Klinik Araştırma
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Yıl 2024, Cilt: 1 Sayı: 1, 42 - 51, 31.01.2024

Öz

Kaynakça

  • Aminiahidashti H, Bozorgi F, Mousavi SJ, Sedighi O, Gorji AM, Rashidian H. Serum Uric Acid Level in Relation to Severity of the Disease and Mortality of Critically Ill Patients. J Lab Physicians. 2017;9(1):42-46.
  • Lee HW, Choi SM, Lee J, et al. Serum Uric Acid Level as a Prognostic Marker in Patients With Acute Respiratory Distress Syndrome. J Intensive Care Med. 2019 ;34(5):404-410.
  • Akbar SR, Long DM, Hussain K, et al. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. Int J Nephrol. 2015;2015:301021.
  • Chen Q, Huang K, Li L, et al. Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study. Ther Clin Risk Manag. 2018;14:1347-1359.
  • Pesquera JIM, Rubio AH, Ruiz IG, et al. La hiperuricemiacomo factor de riesgo cardiovascular y renal. Diálisis y Trasplante. 2011;32(2):57-61.
  • Ioachimescu AG, Brennan DM, Hoar BM, Hazen SL, Hoogwerf BJ. Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study. Arthritis Rheum. 2008;58(2):623-630.
  • Dawson J, Jeemon P, Hetherington L, et al. Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension. 2013;62(1):105-111.
  • Andrassy KM. Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Kidney Int. 2013;84(3):622-623.
  • KDIGO Clinical Practice Guideline for Acute Kidney Injury. AKI definition. Kidney International Supplements 2012;2(1):19-22.
  • Aminiahidashti H, Bozorgi F, Mousavi SJ, Sedighi O, Gorji AM, Rashidian H. Serum Uric Acid Level in Relation to Severity of the Disease and Mortality of Critically Ill Patients. J Lab Physicians. 2017;9(1):42-46.
  • Yeter HH, Eyupoglu D, Pasayev T, Cetik S, Akçay OF, Yıldırım T. Role of Uric Acid Albumin Ratio in Predicting Development of Acute Kidney Injury and Mortality in Intensive Care Unit Patients. Turk J Nephrol. 2019; 28(3): 160-167.
  • Guler A, Dogukan M, Kaya R, Uludag O, Duran M, Tutak A. Retrospective Evaluation of the Effects of Albumin and Hemoglobin Values on the Duration of Hospital Stay and Mortality in Elderly Patients Operated for Hip Fracture. ADYU Journal of Health Sciences. 2018; 4(1):637-647.
  • Horowitz IN, Tai K. Hypoalbuminemia in critically ill children. Arch Pediatr Adolesc Med. 2007;161(11):1048-1052.
  • Leite HP, Rodrigues da Silva AV, de Oliveira Iglesias SB, Koch Nogueira PC. Serum albumin is an independent predictor of clinical outcomes in critically ill children. Critic Care Med. 2016;17(2):e50-e57.
  • Msaad R, Essadik R, Mohtadi K, et al. Predictors of mortality in hemodialysis patients. Pan Afr Med J. 2019; 33:61.
  • Garcia-Pachon E, Padilla-Navas I, Shum C. Serum uric acid to creatinine ratio in patients with chronic obstructive pulmonary disease. Lung. 2007;185(1):21-24.
  • Zhong LL, Song YQ, Tian XY, Can H, Ju KJ. Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease. Medicine [Baltimore]. 2018;97(26):e10967.
  • Albay VB, Tutuncu M. Are Uric Acid Level and Uric Acid/Creatinine Ratio Reliable Biomarkers for Idiopathic Parkinson’s Disease Severity? Med Bull Haseki. 2020;58:315- 319.

The Uric Acid / Albumin Ratio in Acute Kidney Injury Developing in Intensive Care Unit: A Case-Control Study

Yıl 2024, Cilt: 1 Sayı: 1, 42 - 51, 31.01.2024

Öz

Background and Aim: Various scoring systems and markers are used in intensive care practice, and molecules which can predict mortality and change the course of treatment continue to be researched. We aimed to investigate whether uric acid, albumin, uric acid/albumin ratio and uric acid/creatinine ratio were associated with mortality in intensive care cases.
Materials and Methods: Our study was designed retrospectively and involved 600 cases. The uric acid and albumin values of the cases were recorded at the time of admission were recorded, and the uric acid/albumin ratio and uric acid/creatine ratio were calculated. APACHE-II scores and SOFA scores of all the patients at the time of admission were recorded.
Results: Uric acid, uric/albumin ratio, uric acid/creatinine ratios of Groups AKI and Non-AKI were statistically significant(p<0.001, p<0.001, p<0.001, respectively).When exitus and discharged cases were compared, albumin and uric acid/albumin ratios were statistically significant (p<0.050, p<0.050,in order). The cut-off value for albumin was found as 2.75. Mortality increases at the values below 2.75. A meaningful difference was detected between the distributions of albumin cut-off value according to the last condition of the patients (p=0.038). We discovered a notable correlation between albumin ,uric acid/creatinine ratio , APACHE-II , SOFA scores (p values p=0.045; p=0.012; p=0.018; p=0.020,seriatim).
Conclusion: Uric acid/albumin ratio may be a useful biomarker in predicting prognosis in cases of acute kidney injury. We believe that our study will shed light on future studies on the uric acid/albumin ratio in larger populations and different patient groups.

Etik Beyan

Ordu Üniversitesi Klinik Araştırmalar Etik kurulu ,Karar no: 2019/139, Tarih:10.10.2019

Destekleyen Kurum

yok

Kaynakça

  • Aminiahidashti H, Bozorgi F, Mousavi SJ, Sedighi O, Gorji AM, Rashidian H. Serum Uric Acid Level in Relation to Severity of the Disease and Mortality of Critically Ill Patients. J Lab Physicians. 2017;9(1):42-46.
  • Lee HW, Choi SM, Lee J, et al. Serum Uric Acid Level as a Prognostic Marker in Patients With Acute Respiratory Distress Syndrome. J Intensive Care Med. 2019 ;34(5):404-410.
  • Akbar SR, Long DM, Hussain K, et al. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. Int J Nephrol. 2015;2015:301021.
  • Chen Q, Huang K, Li L, et al. Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study. Ther Clin Risk Manag. 2018;14:1347-1359.
  • Pesquera JIM, Rubio AH, Ruiz IG, et al. La hiperuricemiacomo factor de riesgo cardiovascular y renal. Diálisis y Trasplante. 2011;32(2):57-61.
  • Ioachimescu AG, Brennan DM, Hoar BM, Hazen SL, Hoogwerf BJ. Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study. Arthritis Rheum. 2008;58(2):623-630.
  • Dawson J, Jeemon P, Hetherington L, et al. Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension. 2013;62(1):105-111.
  • Andrassy KM. Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Kidney Int. 2013;84(3):622-623.
  • KDIGO Clinical Practice Guideline for Acute Kidney Injury. AKI definition. Kidney International Supplements 2012;2(1):19-22.
  • Aminiahidashti H, Bozorgi F, Mousavi SJ, Sedighi O, Gorji AM, Rashidian H. Serum Uric Acid Level in Relation to Severity of the Disease and Mortality of Critically Ill Patients. J Lab Physicians. 2017;9(1):42-46.
  • Yeter HH, Eyupoglu D, Pasayev T, Cetik S, Akçay OF, Yıldırım T. Role of Uric Acid Albumin Ratio in Predicting Development of Acute Kidney Injury and Mortality in Intensive Care Unit Patients. Turk J Nephrol. 2019; 28(3): 160-167.
  • Guler A, Dogukan M, Kaya R, Uludag O, Duran M, Tutak A. Retrospective Evaluation of the Effects of Albumin and Hemoglobin Values on the Duration of Hospital Stay and Mortality in Elderly Patients Operated for Hip Fracture. ADYU Journal of Health Sciences. 2018; 4(1):637-647.
  • Horowitz IN, Tai K. Hypoalbuminemia in critically ill children. Arch Pediatr Adolesc Med. 2007;161(11):1048-1052.
  • Leite HP, Rodrigues da Silva AV, de Oliveira Iglesias SB, Koch Nogueira PC. Serum albumin is an independent predictor of clinical outcomes in critically ill children. Critic Care Med. 2016;17(2):e50-e57.
  • Msaad R, Essadik R, Mohtadi K, et al. Predictors of mortality in hemodialysis patients. Pan Afr Med J. 2019; 33:61.
  • Garcia-Pachon E, Padilla-Navas I, Shum C. Serum uric acid to creatinine ratio in patients with chronic obstructive pulmonary disease. Lung. 2007;185(1):21-24.
  • Zhong LL, Song YQ, Tian XY, Can H, Ju KJ. Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease. Medicine [Baltimore]. 2018;97(26):e10967.
  • Albay VB, Tutuncu M. Are Uric Acid Level and Uric Acid/Creatinine Ratio Reliable Biomarkers for Idiopathic Parkinson’s Disease Severity? Med Bull Haseki. 2020;58:315- 319.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Anesteziyoloji
Bölüm Research Articles
Yazarlar

Ebru Canakci 0000-0003-2093-9229

Mehmet Şerif Alp 0000-0002-3480-8177

Yunus Emre Güven 0000-0003-4910-5949

Şükran İçöz 0000-0002-6319-7141

Erken Görünüm Tarihi 29 Şubat 2024
Yayımlanma Tarihi 31 Ocak 2024
Gönderilme Tarihi 25 Aralık 2023
Kabul Tarihi 11 Ocak 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 1 Sayı: 1

Kaynak Göster

Vancouver Canakci E, Alp MŞ, Güven YE, İçöz Ş. The Uric Acid / Albumin Ratio in Acute Kidney Injury Developing in Intensive Care Unit: A Case-Control Study. Cerasus J Med. 2024;1(1):42-51.