The effect of hypertension on cognitive dysfunction in female patients with fibromyalgia syndrome
Yıl 2025,
Cilt: 2 Sayı: 1, 49 - 57, 15.02.2025
Mehmet Alptekin Karaçeşme
,
Manolya İlhanlı
,
İlker İlhanlı
Öz
Objective
To evaluate the effect of the presence of Hypertension (HT) on cognitive dysfunction in female patients with Fibromyalgia syndrome (FM).
Methods
A total of 36 female patients diagnosed with FM were included in the study and the patients were divided into 4 equal groups. Group 1 was HT with impaired cognition, Group 2 was HT with normal cognition, Group 3 was non-HT with impaired cognition and Group 4 was non-HT with normal cognition. Mini mental status test (MMST) was used to assess cognitive function.
Results
The median age was 51 (41-77) years and median FM complaint duration was 60 (3-336) months. There was no significant difference between the groups in terms of age and complaint duration (p=0.423 and p=0.308, respectively). Median MMST value was 23.5. Between the groups with normal cognition (groups 2 and 4), MMST median value was similar (p=0.203). Median value of MMST was also similar (p=0.192) between the groups with impaired cognition (groups 1 and 3). Also, the median MMST value in patients with HT was similar to in those without HT (p=0.414).
Conclusion
In conclusion, we did not find that HT increases cognitive dysfunction in female FM patients. This may be due to the fact that our number of patients is not large. Additionally, since HT affects cognitive decline more in elderly, new studies can be conducted by including an older FM patient group and a larger number of patients.
Etik Beyan
This study was provided from the thesis titled ‘Massachusetts General Hospital cognitive and physical functioning questionnaire Turkish version: A reliability validity study’ numbered ‘770489’. The study protocol was approved by the Ondokuz Mayıs University Clinical Research Ethics Committee (date: 29.04.2021, no: 2021/227).Only the abstract of the study was previously published within the proceedings of Black Sea Rheumatology and Pain Symposium conducted on 24-26 May 2024 (Available at https://www.karat.org.tr/wp-content/uploads/2024/06/KARAT-2024-Tam-Metin-Bildiri-Kitabi.pdf). The study was conducted in accordance with the Declaration of Helsinki and followed the ethical standards of the TÜRKİYE.
Kaynakça
- Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547-1555. doi:10.1001/jama.2014.3266
- Bar-On Kalfon T, Gal G, Shorer R, Ablin JN. Cognitive functioning in fibromyalgia: The central role of effort. J Psychosom Res. 2016;87:30-36. doi:10.1016/j.jpsychores.2016.06.004
- Glass JM. Cognitive dysfunction in fibromyalgia syndrome. Journal of Musculoskeletal pain. 2010;18(4):367-372.
- Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-329. doi:10.1016/j. semarthrit.2016.08.012
- Kravitz HM, Katz RS. Fibrofog and fibromyalgia: a narrative review and implications for clinical practice. Rheumatol Int. 2015;35(7):1115-1125. doi:10.1007/s00296-014-3208-7
- Katz RS, Heard AR, Mills M, Leavitt F. The prevalence and clinical impact of reported cognitive difficulties (fibrofog) in patients with rheumatic disease with and without fibromyalgia. J Clin Rheumatol. 2004;10(2):53-58. doi:10.1097/01. rhu.0000120895.20623.9f
- Guarner-Lans V, Ramírez-Higuera A, Rubio-Ruiz ME, Castrejón- Téllez V, Soto ME, Pérez-Torres I. Early Programming of Adult Systemic Essential Hypertension. Int J Mol Sci. 2020;21(4):1203. Published 2020 Feb 11. doi:10.3390/ijms21041203
- Lackland DT, Weber MA. Global burden of cardiovascular disease and stroke: hypertension at the core. Can J Cardiol. 2015;31(5):569-571. doi:10.1016/j.cjca.2015.01.009
- Manolio TA, Olson J, Longstreth WT. Hypertension and cognitive function: pathophysiologic effects of hypertension on the brain. Curr Hypertens Rep. 2003;5(3):255-261. doi:10.1007/ s11906-003-0029-6
- Iadecola C, Gottesman RF. Neurovascular and Cognitive Dysfunction in Hypertension. Circ Res. 2019;124(7):1025-1044. doi:10.1161/CIRCRESAHA.118.313260
- Reyes Del Paso GA, Pulgar A, Duschek S, Garrido S. Cognitive impairment in fibromyalgia syndrome: the impact of cardiovascular regulation, pain, emotional disorders and medication. Eur J Pain. 2012;16(3):421-429. doi:10.1002/ j.1532-2149.2011.00032.x
- Cheon EJ. Hypertension and cognitive dysfunction: a narrative review. J Yeungnam Med Sci. 2023;40(3):225-232. doi:10.12701/ jyms.2022.00605
- Waldstein SR. The relation of hypertension to cognitive function. Current directions in psychological science. 2003;12(1):9-12.
- Jennings JR, Muldoon MF, Ryan CM, et al. Cerebral blood flow in hypertensive patients: an initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks. Hypertension. 1998;31(6):1216-1222. doi:10.1161/01.hyp.31.6.1216
- Hughes TM, Sink KM. Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens. 2016;29(2):149-157. doi:10.1093/ajh/hpv180
- Fatima G, Kumar P. A13467 Deciphering the prevalence of hypertension in patients with Fibromyalgia Syndrome. Journal of Hypertension. 2018;36:e74.
- Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175-191. doi:10.3758/bf03193146
- Dick BD, Verrier MJ, Harker TK, Rashiq S. Disruption of cognitive function in fibromyalgia syndrome. Pain. 2008;139(3):610-616. doi:10.1016/j.pain.2008.06.017
- Mitchell, A.J. The Mini-Mental State Examination (MMSE): Update on Its Diagnostic Accuracy and Clinical Utility for Cognitive Disorders. In: Larner, A.J. (eds) Cognitive Screening Instruments. Springer, Cham. 2017:37-48.
- Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198. doi:10.1016/0022-3956(75)90026-6
- Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi. 2002;13(4):273-281.
- Hinkle DE, Wiersma W, Jurs SG. Applied Statistics for the Behavioral Sciences. 5th ed. Boston: Houghton Mifflin; 2003.
- Düğeroğlu H. Fibromiyalji tanısı konulan hastalarda komorbid hastalıkların görülme sıklığı. Ortadoğu Tıp Dergisi. 2019;11(2):131-135.
- Glass JM. Fibromyalgia and cognition. J Clin Psychiatry. 2008;69 Suppl 2:20-24
- Gifford KA, Badaracco M, Liu D, et al. Blood pressure and cognition among older adults: a meta-analysis. Arch Clin Neuropsychol. 2013;28(7):649-664. doi:10.1093/arclin/act046
- Fischer AL, Bernstein DM, Thornton WL. Vascular health modifies theory of mind performance in older adults. J Gerontol B Psychol Sci Soc Sci. 2014;69(2):219-227. doi:10.1093/geronb/ gbs120
- Fischer AL, O’Rourke N, Loken Thornton W. Age Differences in Cognitive and Affective Theory of Mind: Concurrent Contributions of Neurocognitive Performance, Sex, and Pulse Pressure. J Gerontol B Psychol Sci Soc Sci. 2017;72(1):71-81. doi:10.1093/geronb/gbw088
- Yeung SE, Loken Thornton W. “Do it-yourself”: Home blood pressure as a predictor of traditional and everyday cognition in older adults. PLoS One. 2017;12(5):e0177424. Published 2017 May 17. doi:10.1371/journal.pone.0177424
- Kircher JA, Cherry BJ, Zettel-Watson L. Blood pressure as a predictor of everyday cognitive function in aging adults with and without fibromyalgia. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021;28(3):327-345. doi:10.1080/1382558 5.2020.1757028
- Reyes Del Paso GA, Pulgar A, Duschek S, Garrido S. Cognitive impairment in fibromyalgia syndrome: the impact of cardiovascular regulation, pain, emotional disorders and medication. Eur J Pain. 2012;16(3):421-429. doi:10.1002/ j.1532-2149.2011.00032.x
- Glynn RJ, Beckett LA, Hebert LE, Morris MC, Scherr PA, Evans DA. Current and remote blood pressure and cognitive decline. JAMA. 1999;281(5):438-445. doi:10.1001/jama.281.5.438
- de Menezes ST, Giatti L, Brant LCC, et al. Hypertension, Prehypertension, and Hypertension Control: Association With Decline in Cognitive Performance in the ELSA-Brasil Cohort. Hypertension. 2021;77(2):672-681. doi:10.1161/ HYPERTENSIONAHA.120.16080
- Gostine M, Davis F, Roberts BA, et al. Clinical Characteristics of Fibromyalgia in a Chronic Pain Population. Pain Pract. 2018;18(1):67-78. doi:10.1111/papr.12583
- Tadic M, Cuspidi C, Hering D. Hypertension and cognitive dysfunction in elderly: blood pressure management for this global burden. BMC Cardiovasc Disord. 2016;16(1):208. Published 2016 Nov 3. doi:10.1186/s12872-016-0386-0.
- Walzak LC, Loken Thornton W. The role of illness burden in theory of mind performance among older adults. Exp Aging Res. 2018;44(5):427-442. doi:10.1080/0361073X.2018.1521494
- Fitzcharles MA, Ste-Marie PA, Shir Y, Lussier D. Management of fibromyalgia in older adults. Drugs Aging. 2014;31(10):711- 719. doi:10.1007/s40266-014-0210-4
- Brusco I, Justino AB, Silva CR, Scussel R, Machado-de-Ávila RA, Oliveira SM. Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice. Eur J Pharmacol. 2021;895:173870. doi:10.1016/j. ejphar.2021.173870
- Alptekin Karaçeşme M, İlhanlı M, İlhanlı İ. Turkish version of the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire: A reliability and validity study. Arch Rheumatol. 2024;39(2):294-302. Published 2024 Mar 10. doi:10.46497/ArchRheumatol.2024.10337
Hipertansiyonun fibromiyalji sendromu olan kadın hastalarda bilişsel disfonksiyon üzerindeki etkisi
Yıl 2025,
Cilt: 2 Sayı: 1, 49 - 57, 15.02.2025
Mehmet Alptekin Karaçeşme
,
Manolya İlhanlı
,
İlker İlhanlı
Kaynakça
- Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547-1555. doi:10.1001/jama.2014.3266
- Bar-On Kalfon T, Gal G, Shorer R, Ablin JN. Cognitive functioning in fibromyalgia: The central role of effort. J Psychosom Res. 2016;87:30-36. doi:10.1016/j.jpsychores.2016.06.004
- Glass JM. Cognitive dysfunction in fibromyalgia syndrome. Journal of Musculoskeletal pain. 2010;18(4):367-372.
- Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-329. doi:10.1016/j. semarthrit.2016.08.012
- Kravitz HM, Katz RS. Fibrofog and fibromyalgia: a narrative review and implications for clinical practice. Rheumatol Int. 2015;35(7):1115-1125. doi:10.1007/s00296-014-3208-7
- Katz RS, Heard AR, Mills M, Leavitt F. The prevalence and clinical impact of reported cognitive difficulties (fibrofog) in patients with rheumatic disease with and without fibromyalgia. J Clin Rheumatol. 2004;10(2):53-58. doi:10.1097/01. rhu.0000120895.20623.9f
- Guarner-Lans V, Ramírez-Higuera A, Rubio-Ruiz ME, Castrejón- Téllez V, Soto ME, Pérez-Torres I. Early Programming of Adult Systemic Essential Hypertension. Int J Mol Sci. 2020;21(4):1203. Published 2020 Feb 11. doi:10.3390/ijms21041203
- Lackland DT, Weber MA. Global burden of cardiovascular disease and stroke: hypertension at the core. Can J Cardiol. 2015;31(5):569-571. doi:10.1016/j.cjca.2015.01.009
- Manolio TA, Olson J, Longstreth WT. Hypertension and cognitive function: pathophysiologic effects of hypertension on the brain. Curr Hypertens Rep. 2003;5(3):255-261. doi:10.1007/ s11906-003-0029-6
- Iadecola C, Gottesman RF. Neurovascular and Cognitive Dysfunction in Hypertension. Circ Res. 2019;124(7):1025-1044. doi:10.1161/CIRCRESAHA.118.313260
- Reyes Del Paso GA, Pulgar A, Duschek S, Garrido S. Cognitive impairment in fibromyalgia syndrome: the impact of cardiovascular regulation, pain, emotional disorders and medication. Eur J Pain. 2012;16(3):421-429. doi:10.1002/ j.1532-2149.2011.00032.x
- Cheon EJ. Hypertension and cognitive dysfunction: a narrative review. J Yeungnam Med Sci. 2023;40(3):225-232. doi:10.12701/ jyms.2022.00605
- Waldstein SR. The relation of hypertension to cognitive function. Current directions in psychological science. 2003;12(1):9-12.
- Jennings JR, Muldoon MF, Ryan CM, et al. Cerebral blood flow in hypertensive patients: an initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks. Hypertension. 1998;31(6):1216-1222. doi:10.1161/01.hyp.31.6.1216
- Hughes TM, Sink KM. Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens. 2016;29(2):149-157. doi:10.1093/ajh/hpv180
- Fatima G, Kumar P. A13467 Deciphering the prevalence of hypertension in patients with Fibromyalgia Syndrome. Journal of Hypertension. 2018;36:e74.
- Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175-191. doi:10.3758/bf03193146
- Dick BD, Verrier MJ, Harker TK, Rashiq S. Disruption of cognitive function in fibromyalgia syndrome. Pain. 2008;139(3):610-616. doi:10.1016/j.pain.2008.06.017
- Mitchell, A.J. The Mini-Mental State Examination (MMSE): Update on Its Diagnostic Accuracy and Clinical Utility for Cognitive Disorders. In: Larner, A.J. (eds) Cognitive Screening Instruments. Springer, Cham. 2017:37-48.
- Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198. doi:10.1016/0022-3956(75)90026-6
- Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi. 2002;13(4):273-281.
- Hinkle DE, Wiersma W, Jurs SG. Applied Statistics for the Behavioral Sciences. 5th ed. Boston: Houghton Mifflin; 2003.
- Düğeroğlu H. Fibromiyalji tanısı konulan hastalarda komorbid hastalıkların görülme sıklığı. Ortadoğu Tıp Dergisi. 2019;11(2):131-135.
- Glass JM. Fibromyalgia and cognition. J Clin Psychiatry. 2008;69 Suppl 2:20-24
- Gifford KA, Badaracco M, Liu D, et al. Blood pressure and cognition among older adults: a meta-analysis. Arch Clin Neuropsychol. 2013;28(7):649-664. doi:10.1093/arclin/act046
- Fischer AL, Bernstein DM, Thornton WL. Vascular health modifies theory of mind performance in older adults. J Gerontol B Psychol Sci Soc Sci. 2014;69(2):219-227. doi:10.1093/geronb/ gbs120
- Fischer AL, O’Rourke N, Loken Thornton W. Age Differences in Cognitive and Affective Theory of Mind: Concurrent Contributions of Neurocognitive Performance, Sex, and Pulse Pressure. J Gerontol B Psychol Sci Soc Sci. 2017;72(1):71-81. doi:10.1093/geronb/gbw088
- Yeung SE, Loken Thornton W. “Do it-yourself”: Home blood pressure as a predictor of traditional and everyday cognition in older adults. PLoS One. 2017;12(5):e0177424. Published 2017 May 17. doi:10.1371/journal.pone.0177424
- Kircher JA, Cherry BJ, Zettel-Watson L. Blood pressure as a predictor of everyday cognitive function in aging adults with and without fibromyalgia. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021;28(3):327-345. doi:10.1080/1382558 5.2020.1757028
- Reyes Del Paso GA, Pulgar A, Duschek S, Garrido S. Cognitive impairment in fibromyalgia syndrome: the impact of cardiovascular regulation, pain, emotional disorders and medication. Eur J Pain. 2012;16(3):421-429. doi:10.1002/ j.1532-2149.2011.00032.x
- Glynn RJ, Beckett LA, Hebert LE, Morris MC, Scherr PA, Evans DA. Current and remote blood pressure and cognitive decline. JAMA. 1999;281(5):438-445. doi:10.1001/jama.281.5.438
- de Menezes ST, Giatti L, Brant LCC, et al. Hypertension, Prehypertension, and Hypertension Control: Association With Decline in Cognitive Performance in the ELSA-Brasil Cohort. Hypertension. 2021;77(2):672-681. doi:10.1161/ HYPERTENSIONAHA.120.16080
- Gostine M, Davis F, Roberts BA, et al. Clinical Characteristics of Fibromyalgia in a Chronic Pain Population. Pain Pract. 2018;18(1):67-78. doi:10.1111/papr.12583
- Tadic M, Cuspidi C, Hering D. Hypertension and cognitive dysfunction in elderly: blood pressure management for this global burden. BMC Cardiovasc Disord. 2016;16(1):208. Published 2016 Nov 3. doi:10.1186/s12872-016-0386-0.
- Walzak LC, Loken Thornton W. The role of illness burden in theory of mind performance among older adults. Exp Aging Res. 2018;44(5):427-442. doi:10.1080/0361073X.2018.1521494
- Fitzcharles MA, Ste-Marie PA, Shir Y, Lussier D. Management of fibromyalgia in older adults. Drugs Aging. 2014;31(10):711- 719. doi:10.1007/s40266-014-0210-4
- Brusco I, Justino AB, Silva CR, Scussel R, Machado-de-Ávila RA, Oliveira SM. Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice. Eur J Pharmacol. 2021;895:173870. doi:10.1016/j. ejphar.2021.173870
- Alptekin Karaçeşme M, İlhanlı M, İlhanlı İ. Turkish version of the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire: A reliability and validity study. Arch Rheumatol. 2024;39(2):294-302. Published 2024 Mar 10. doi:10.46497/ArchRheumatol.2024.10337