Kronik Obstruktif Akciğer Hastalığı (KOAH) Tanılı Hastalarda Sistemik İmmün İnflamasyon İndeksinin (SII) Prognostik Önemi

Öz

Amaç: Bu çalışmanın amacı, Kronik Obstruktif Akciğer Hastalığı (KOAH) tanılı hastalarda Sistemik İmmün İnflamasyon İndeksi'nin (SII) prognostik önemini değerlendirmektir. SII'nin KOAH hastalarının acil serviste sonlanımını öngörmek için kullanılabilecek basit ve etkili bir indeks olup olmadığını değerlendireceğiz. Gereç ve Yöntem: Bu çalışma tek merkezli retrospektif gözlemsel bir çalışma olarak planlanmıştır. 18 yaşından büyük olan ve acil serviste KOAH alevlenme tanısı konulan hastalar dahil edilmiş olup hastaların sistem üzerinden başvuru şikayeti, laboratuvar özellikleri ve özgeçmiş bilgilerine ulaşılıp veri kayıt formuna not edilmiştir. SII = Trombosit sayısı x Nötrofil sayısı/Lenfosit sayısı formulü ile hesaplanıp sonlanımı öngörmedeki gücü analiz edilmiştir. Bulgular: Çalışmaya toplam 177 hasta dahil edişmiş olup ortalama yaş 72,11±9,96 olarak hesaplandı. En sık başvuru şikayetinin 159 (89,8) hastada görülen dispne olduğu bulundu. Hastaların 123 tanesi acil servisten taburcu olurken; 22 tanesi servise, 32 tanesi yoğun bakım ünitesine yatırıldı. 177 hastadan 68 tanesinin exitus ile sonuçlandığı görüldü. Sonlanım için yaptığımız eğri altında kalan alan analizinde SII değerinin ayırıcı bir tanı olduğu istatistik olarak belirlenmiştir (p<0,001). Sonlanımda SII için anlamlı ayırıcı tanı değeri 2282,54 üzerinde olmasıdır. Fakat SII, KOAH hastalarında survivor için ayırıcı bir tanı değildir (p=0,572). Sonuç: Sonuçlarımız, SII'nin KOAH hastalarında sonlanımın bir göstergesi olarak kullanılabileceğini ve hastalığın prognozunun değerlendirilmesinde potansiyel bir araç olabileceğini göstermektedir.

Anahtar Kelimeler

• KOAH
• SII
• Prognoz
• Inflamasyon
• Acil servis

The Prognostic Importance of the Systemic Immune Inflammation Index (SII) in Patients with Chronic Obstructive Pulmonary Disease (COPD)

Öz

Aim: The aim of this study was to evaluate the prognostic significance of the Systemic Immune Inflammation Index (SII) in patients with a diagnosis of Chronic Obstructive Pulmonary Disease (COPD). We will evaluate whether SII is a simple and effective index that can be used to predict emergency department outcomes in patients with COPD. Materials and Methods: This study was planned as a single-center retrospective observational study. Patients older than 18 years of age who were diagnosed with COPD exacerbation in the emergency department were included, and complaints, laboratory characteristics, and background information of the patients were accessed and recorded in the data registration form. SII=Platelet count x Neutrophil count/Lymphocyte count was calculated and its power in predicting outcome was analyzed. Results: A total of 177 patients were included in the study, and the mean age was calculated as 72.11±9.96 years. Dyspnea was found to be the most common complaint in 159(89.8) patients. While 123 of the patients were discharged from the emergency department; 22 of them were admitted to the service and 32 of them were admitted to the intensive care unit. It was observed that 68 of 177 patients resulted in exitus. In the analysis of the area under the curve for the outcome, it was statistically determined that the SII value is a differential diagnosis(p<0.001). The significant differential diagnosis value for SII in the outcome is over 2282.54. However, SII is not a differential diagnosis for survivors in COPD patients(p=0.572). Conclusion: Our results show that SII can be used as an indicator of outcomes in COPD patients and a potential tool in the evaluation of the prognosis of the disease.

Anahtar Kelimeler

• COPD
• SII
• Prognosis
• Inflammation
• Emergency department

Kaynakça

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