Evaluation of clinicopathological characteristics in single-organ cutaneous small vessel vasculitis

Öz

Objective: Cutaneous vasculitis includes a wide and heterogeneous spectrum of vasculitic syndromes characterized by inflam-mation of skin blood vessels. When the disease is confined to the skin, the term single-organ cutaneous small vessel vasculitis is used. Data regarding this entity is limited. This study aims to retrospectively evaluate the clinicopathological characteristics of patients who were diagnosed with single-organ cutaneous small vessel vasculitis retrospectively. Material and Methods: One hundred eight patients were included in the study. Demographic characteristics, clinical features, laboratory findings, etiological factors, treatment modalities, and prognoses of 108 patients were evaluated. Biopsy speci-mens of patients were re-evaluated histopathologically. Results: Most frequently acral involvement, and palpable purpura were observed in 82.4% of the patients. Clinical presentation was acute in 80 (74.1%) patients and relapse was seen in 24 (23.1%) patients. Relapse and ulcerative lesions were observed more frequently in chronic patients. The mean age was found to be lower in relapsing patients. Etiology was idiopathic in 75% of the patients. The elevation of CRP was significant in patients with severe fibrinoid necrosis and subcutaneous tissue involvement. Treatment option with topical corticosteroids and nonsteroidal anti-inflammatory drugs (54,3%) was the most common type. The clinical and histopathological features were found to have no effect on relapse, but treatment type was associated with relapse. Conclusion: There are few studies on single organ cutaneous small vessel vasculitis. Results were similar to the features of the other studies. Further studies in which clinical and histopathological features will be evaluated together are needed.

Anahtar Kelimeler

• Single-organ cutaneous small vessel vasculitis
• Clinical features
• Histopathology

Proje Numarası

2020GOKAE-0374

Tek-organ kutanöz küçük damar vaskülitinin klinikopatolojik özelliklerinin değerlendirilmesi

Öz

Amaç: Kutanöz vaskülit, deri kan damarlarının enflamasyonu ile karakterize geniş ve heterojen bir vaskülitik sendrom spek-trumunu içerir. Hastalık deriyle sınırlı olduğunda, tek organlı kutanöz küçük damar vasküliti terimi kullanılır. Bu antiteye ilişkin veriler sınırlıdır. Bu çalışmada tek organlı kutanöz küçük damar vasküliti tanısı alan hastaların klinikopatolojik özelliklerinin retrospektif olarak değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler:Yüz sekiz hasta çalışmaya dahil edildi. Hastaların demografik özellikleri, klinik özellikleri, laboratuvar bul-guları, etiyolojik faktörleri, tedavi modaliteleri ve prognozları değerlendirildi. Hastaların biyopsi örnekleri histopatolojik olarak yeniden değerlendirildi. Bulgular: Hastaların %82,4’ünde akral tutulum mevcuttu. Palpabl purpura (%82,4) en sık görülen deri lezyonuydu. Klinik prez-entasyon 80 (%74,1) hastada akut iken, 24 (%23,1) hastada nüks görüldü. Kronik hastalarda nüks ve ülseratif lezyonlar daha sık gözlendi. Nüks eden hastalarda yaş ortalaması daha düşük bulundu. Hastaların %75’inde etiyoloji idiyopatikti. CRP yüksekliği şiddetli fibrinoid nekroz ve subkutan doku tutulumu olan hastalarda anlamlıydı. Topikal kortikosteroidler ve nonsteroid anti-inflamatuvar ilaçlarla tedavi seçeneği (%54,3) en yaygın tipti. Klinik ve histopatolojik özelliklerin nüks üzerinde etkisi olmadığı, ancak tedavi tipinin nüks ile ilişkili olduğu bulunmuştur. Sonuç:Tek organ kutanöz küçük damar vasküliti ile ilgili az sayıda çalışma vardır. Sonuçlar diğer çalışmaların özelliklerine ben-zerdi. Klinik ve histopatolojik özelliklerin birlikte değerlendirileceği ileri çalışmalara ihtiyaç vardır

Anahtar Kelimeler

• Tek-organ kutanöz küçük damar vasküliti
• Klinik özellikler
• Histopatoloji

Proje Numarası

2020GOKAE-0374

Etik Beyan

The study was approved by the Ethics Committee of Izmir Ataturk Training and Research Hospital and adhered to the principles of the Declaration of Helsinki (2020GOKAE-0374) on 17 September 2020

Kaynakça

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