Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Yıl 2024, Cilt: 11 Sayı: 1, 50 - 57, 02.08.2024

Özlem Gürsoy Kol Fevzi Aytemiz Sevda Manap Haydar Yüksek

https://doi.org/10.48138/cjo.1484675

Öz

In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3c, f, e) reacted with 4-methylthiobenzaldehyde to afford 3-alkyl(aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-ones (4c, f, e). The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkyl(aryl)-4-(4-methylthiobenzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds' antimicrobial activity was screened.

Anahtar Kelimeler

1,2,4-triazole, Synthesis, Antioxidant activity, Antimicrobial activity

Etik Beyan

The approval of an ethical committee is not required.

Destekleyen Kurum

Scientific Research Projects Coordination Unit of Kafkas University

Proje Numarası

2016-FM-61

Teşekkür

The authors thank Dr. Muzaffer Alkan for their contribution.

Kaynakça

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