4- NİTROSO -1- PHENYL -3- METHYL -2- PYRAZOLİN -5- ONE IN THE SYNTHESIS OF: SOME NEW 4- SUBSTITUTED HETEOCYCLES OF PHARMACEUTICAL INTEREST

Yıl 1995, Cilt: 41 , 0 - 0, 01.01.1995

M. A Metwally

https://doi.org/10.1501/Commub_0000000407

Öz

Condensation of 4- nitrosopyrazolone (1) with active methylene components namely, malo- nonitrile, acetophenone, co-cyano-acetophenone and / or 1,3- diphenylacetone gave compounds (2a-c) and (4). Treatment of (2a, 2b) with hydrazine hydrate gave the aminopyrazoles (3a, 3b). Reaction of (1) with some lıydrazines afforded derivatives (5, 6, 7a, 7b).
While the condensation of (1) with hydrazine hydrate gave the bispyrazolone (8). The structures of the ring systems have been confirmed by their IR, !H-NMR and rnass spectral data.

Anahtar Kelimeler

4- NİTROSO, 1- PHENYL, 3- METHY

Kaynakça

• 4- NİTROSO -1- PHENYL -3- METHYL -2- PYRAZOLİN -5- ONE IN THE SYNTHESIS OF: SOME NEW 4- SUBSTITUTED HETEOCYCLES OF PHARMACEUTICAL INTEREST