Polikistik Over Sendromunda Arjinin Metabolizmasının Fonksiyonu

Öz

Polikistik over sendromu (PKOS), doğurganlık çağındaki kadınları etkileyen yaygın bir hastalıktır. Üreme ve metabolik bozukluklarla ilişkilendirilen PKOS daha sonra inflamatuar durumlara neden olan anormal oksidasyon durumundan kaynaklanabilmektedir. Antioksidanların over fizyolojisinde, foliküler büyümede, oosit olgunlaşmasında ve yumurtalık steroid biyosentezinde rol oynayan ana faktör olduğu düşünülmektedir. Overlerdeki oksidatif stres veya düşük antioksidan durumu, PKOS gelişimine zemin hazırlayan en önemli mekanizmalardan biri olarak kabul edilebilir. NO, substrat olarak L-arginin'i L-sitrulline dönüştüren nitrik oksit sentaz (NOS) tarafından oluşturulur. Günümüz literatürü ışığında NOS ile etkileşen arjininin metabolizmasının, PKOS patofizyolojisindeki rolleri üzerine yapılan araştırmalar derlenmiştir.

Anahtar Kelimeler

• polikistik over sendromu
• Arjinin
• poliaminler

Function of Arginine Metabolism in Polycystic Ovary Syndrome

Öz

Polycystic ovary syndrome (PCOS) is a common disease affecting women of reproductive age. PCOS, which is associated with reproductive system and metabolic disorders, may result from an abnormal oxidation state that subsequently causes inflammatory conditions. Antioxidants are thought to be the main factor playing a role in ovarian physiology, follicular growth, oocyte maturation, and ovarian steroid biosynthesis. Oxidative stress or low antioxidant status in the ovaries can be considered one of the most important mechanisms that paves the way for the development of PCOS. NO is formed by nitric oxide synthase (NOS), which converts L-arginine as a substrate to L-citrulline. In the light of today's literature, research on the roles of arginine metabolism, which interacts with NOS, in the pathophysiology of PCOS has been compiled.

Anahtar Kelimeler

• polycystic ovary syndrome
• Arginin
• polyamines

Kaynakça

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