Dişi Kedilerde Ovariohisterektomi Sonrası Kan Koagülasyon Profilindeki Değişiklikler

Yıl 2026, Cilt: 3 Sayı: 1, 8 - 13, 28.02.2026

Damla Tuğçe Okur , Vefa Tohumcu

https://doi.org/10.62425/crihs.1832432

https://izlik.org/JA32TS37SJ

Öz

Amaç: Sağlıklı dişi kedilerde elektif ovariohisterektomi (OHE) sonrası kan koagülasyon sisteminde meydana gelen değişiklikleri değerlendirmek ve cerrahi travmaya bağlı gelişebilecek olası hiperkoagülabilite eğilimini belirlemek.
Yöntemler: Toplam yirmi sağlıklı dişi kediden operasyon öncesi, operasyon hemen sonrası ve 24 saat sonrası olmak üzere üç zaman noktasında kan örnekleri alınmıştır. Antitrombin III, fibrinojen, D-dimer, trombin zamanı (TT) ve aktive parsiyel tromboplastin zamanı (aPTT) gibi temel koagülasyon parametreleri analiz edilerek hemostatik yanıt değerlendirilmiştir.
Bulgular: Operasyon sonrasında fibrinojen düzeylerinde anlamlı bir artış saptanmış, bu artış 24. saatte başlangıç değerlerine dönmüştür (p = 0.025). TT ve aPTT değerlerinde 24. saatte anlamlı düşüşler gözlenmiş ve bu durum hiperkoagülabilite eğilimini desteklemiştir (p = 0.003 ve p = 0.0437). Antitrombin III düzeylerinde cerrahi sonrası azalma görülmekle birlikte değişim istatistiksel açıdan anlamlı bulunmamıştır (p = 0.056). D-dimer düzeyleri zaman noktaları arasında anlamlı bir farklılık göstermemiştir.
Sonuç: Elektif OHE, sağlıklı kedilerde erken postoperatif dönemde koagülasyon parametrelerinde geçici ancak ölçülebilir değişikliklere neden olmaktadır. Bu geçici hemostatik dalgalanmalar, potansiyel trombotik komplikasyonların erken fark edilmesi ve yönetimi açısından klinik açıdan önemli olabilir.

Anahtar Kelimeler

Antitrombin III , D-dimer , Fibrinojen , Koagülasyon Zamanı , Ovariohisterektomi.

Etik Beyan

Bu çalışma Atatürk Üniversitesi Araştırma Hayvanları Uygulama Merkezi'nde gerçekleştirilmiştir. Bu araştırma, Atatürk Üniversitesi Veteriner Fakültesi Etik Kurulu tarafından onaylanmıştır (ATAUNİHADYEK, Ref No: 75296309-050.01.04-2400042119, Tarih: 17/2024).

Destekleyen Kurum

Bu araştırma, Atatürk Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Ofisi tarafından “TCD-2024-13864” proje numarasıyla desteklenmiştir.

Proje Numarası

TCD-2024-13864

Changes in The Blood Coagulation Profile After Ovariohysterectomy in Female Cats

https://izlik.org/JA32TS37SJ

Öz

Objective: To evaluate perioperative changes in coagulation parameters and identify potential hypercoagulable tendencies in healthy female cats undergoing elective ovariohysterectomy (OHE).
Methods: Twenty healthy female cats undergoing elective OHE were prospectively assessed. Blood samples were collected at three time points: preoperatively, immediately postoperatively, and 24 hours after surgery. Hemostatic markers, including antithrombin III, fibrinogen, D-dimer, thrombin time (TT), and activated partial thromboplastin time (aPTT), were measured to characterize coagulation dynamics.
Results: Fibrinogen concentrations increased significantly immediately after surgery and returned to baseline by 24 hours (p = 0.025). TT and aPTT values demonstrated significant decreases at 24 hours (p = 0.003 and p = 0.0437, respectively), consistent with a shift toward hypercoagulability. Antithrombin III levels declined postoperatively but did not reach statistical significance (p = 0.056). No significant changes were observed in D-dimer levels across the three time points.
Conclusion: Elective OHE induces transient postoperative alterations in coagulation markers in healthy cats, including increased fibrinogen and reduced TT and aPTT, suggesting a short-term shift toward hypercoagulability. These findings underscore the importance of perioperative coagulation monitoring to anticipate and mitigate possible thrombotic risks.

Anahtar Kelimeler

Antithrombin III , Coagulation Time , D-dimer , Fibrinogen , Ovariohysterectomy.

Etik Beyan

This study was carried out at Atatürk University Reserch Animals Application Center. This research was approved by The Ethics Committee of the Faculty of Veterinary Medicine, Atatürk University (ATAUNİHADYEK, Ref No: 75296309-050.01.04-2400042119, Tarih: 17/2024)

Destekleyen Kurum

This research was supported by Atatürk University Scientific Research Projects Coordination Office as project number “TCD-2024-13864.”

Proje Numarası

TCD-2024-13864

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