Chimeric antigen receptor (CAR-T) cell and use in therapy

Yıl 2023, Cilt: 3 Sayı: 1, 1 - 5, 30.06.2023

Zeynep Aral , Sena Çakır

Öz

Chimeric Antigen Receptor (CAR) T Cell therapy is a cellular therapy method that has developed rapidly in recent years and is especially promising in cancer treatment. Although there is a long history of cell-mediated therapies, the development of CARs has recently been among the cell-mediated therapies. Among the biggest reasons for this is the success of CAR-T Cell therapy against hematological malignancies. In this review, the history of cell-mediated therapy methods, the structure of the CAR-T Cell, its production methods, the method of application during treatment, its mechanism of action and the diseases in which this cell-mediated therapy method is used are discussed.

Anahtar Kelimeler

Chimeric Antigen Receptor, cell-mediated therapy, T cell, hematological cancers

Kimerik antijen receptorü (CAR-T) hücresi ve tedavide kullanımı

Öz

Kimerik Antijen Reseptörü (CAR) T Hücre tedavisi son yıllarda hızla gelişen ve özellikle kanser tedavisinde umut vadeden bir hücresel terapi yöntemidir. Hücre aracılı terapilerin uzun süreli bir geçmişi mevcut olmakla birlikte CAR’ların gelişimi yakın bir geçmişte hücre aracılı tedavi yöntemleri arasında yer bulmuştur. Bunun en büyük sebepleri arasında CAR-T Hücre tedavisinin hematolojik maligniteler karşısındaki başarısı gelmektedir. Bu makalede hücre aracılı terapi yöntemlerinin tarihçesi, CAR-T Hücresinin yapısı, üretim yöntemleri, tedavi sırasında uygulanma yöntemi, etki mekanizması ve bu hücre aracılı terapi yönteminin kullanıldığı hastalıklara değinilmektedir.

Anahtar Kelimeler

Kimerik Antijen Reseptör, hücre aracılı terapi, T hücre, hematolojik kanserler

Kaynakça

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