Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi

Neslihan Önenli Mungan; Fatih Gürbüz; Eda Mengen; Özden Özgür; Ali Kemal Topaloğlu; Bilgin Yüksel

doi:10.17826/cutf.46470

EN TR

Evaluation of Two Different Pamidronate Treatment Protocols in Children with Osteogenesis Imperfecta

Abstract

Purpose: Osteogenesis imperfecta is an inherited disorder of connective tissue. Children with this condition suffer from recurrent fractures, deformities, osteoporosis and pain. Over the recent years, pamidronate became the standard treatment choice. However the optimal dose and interval have not been defined yet. The main of this study was to compare of two different pamidronate regime. Materials and Methods: 12 patients aged 42.3 ± 37.4 months were studied. At the beginning patients had received pamidronate infusion at a dose of 1.5 mg/kg/day once, every two months with duration of 23.5 ± 9.0 months (first protocol), than switched to a dose of 1mg/kg/day for three consecutive days, every three months with duration of 18.5 ± 5.1 months (second protocol). The bone mineral density Z-score was evaluated yearly. Results: Annual fracture rate decreased from 6.3 ± 5.5 to 1.1 ± 1.3 (p=0.001) in the first and from 1.1 ± 1.3 to 0.0 ± 0.0 (p

Keywords

Osteogenesis imperfecta, pamidronate, children.

Kaynakça

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Yazışma Adresi / Address for Correspondence: Dr. Fatih GÜRBÜZ Çukurova Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, ADANA Email: fggurbuz@yahoo.com G eliş tarihi/Received on: 20.01.2014
Kabul tarihi/Accepted on:27.02.2014

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Neslihan Önenli Mungan Bu kişi benim

Fatih Gürbüz Bu kişi benim

Eda Mengen Bu kişi benim

Özden Özgür Bu kişi benim

Ali Kemal Topaloğlu Bu kişi benim

Bilgin Yüksel Bu kişi benim

Yayımlanma Tarihi

22 Temmuz 2014

Gönderilme Tarihi

22 Temmuz 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 1970 Cilt: 39 Sayı: 3

DOI

https://doi.org/10.17826/cutf.46470

IZ

https://izlik.org/JA47GS67JD

MLA

Mungan, Neslihan Önenli, vd. “Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi”. Cukurova Medical Journal, c. 39, sy 3, Eylül 2014, ss. 532-9, doi:10.17826/cutf.46470.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Osteogenezis İmperfekta Olan Çocuklarda İki Farklı Pamidronat Protokolünün Değerlendirilmesi

Evaluation of Two Different Pamidronate Treatment Protocols in Children with Osteogenesis Imperfecta

Abstract

Keywords