Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects

Ahmet Taylan Çebi

doi:10.17826/cumj.631371

TR EN

Topikal ve sistemik flurbiprofenin gömülü üçüncü molar cerrahisi sonrası ağrı ve ödem üzerine etkilerinin ve gastrointestinal yan etkilerinin karşılaştırılması

Öz

Amaç: Bu çalışmanın amacı, gömülü üçüncü molar diş cerrahisinden sonra sistemik ve topikal nonsteroid antiinflamatuar ilaçların postoperatif ağrı ve ödem üzerine etkileri ve ayrıca gastrointestinal yan etkilerin değerlendirilmesidir.
Gereç ve Yöntem: Bu klinik çalışmaya, benzer pozisyonda mandibular gömülü üçüncü molar dişe sahip 100 sağlıklı hasta dahil edilmiştir. Operasyon sonrasında hastalar iki gruba ayrıldı, bir gruba Flurbiprofen tablet uygulanırken, diğer gruba da Flurbiprofen 0.25% Oral spray uygulandı. Ağrı, postoperatif olarak Vizüel Ağrı Skalası (VAS) ile değerlendirildi. Ödem ölçümü preoperatif ve postoperatif 2. ve 7. günlerde yapıldı. Mide bulantısı, mide yanması, dispepsi, kusma ve ishal gibi nosteroid anti-inflamatuar ilaç kullanımına bağlı gastrointestinal yan etkiler hastalardan alınan bilgilere göre kaydedildi.
Bulgular: Gruplar arasında 6, 8, 12, 24 ve 48. saatler arasında Vizüel Ağrı Skalası düzeyleri açısından istatistiksel olarak anlamlı fark vardı. Sistemik nonsteroidal antienflamatuar ilaç grubunun 2. gündeki ödem ölçümleri lokal topikal nonsteroidal antiinflamatuvar ilaç grubuna göre istatistiksel olarak daha düşük bulundu.
Sonuç: Topikal kullanılan nonsteroid anti-inflamatuar ilaçların ağrı ve ödem üzerine etkinlikleri sistemik nonsteroid anti-inflamatuar ilaçlara göre daha düşük olmasına rağmen, daha az gastrointestinal yan etkiye sahip olduğu için tercih edilebilir.

Anahtar Kelimeler

Ağrı,ödem,üçüncü molar diş

Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects

Abstract

Purpose: The aim of this study was to evaluate the effects of systemic and topical nonsteroidal anti-inflammatory agents on postoperative pain and edema and also gastrointestinal side effects after impacted third molar surgery.
Materials and Methods: In this clinical study, 100 healthy patients with mandibular impacted third molar teeth in a similar position were included. After the operation, patients were divided into two groups, one group received Flurbiprofen tablets and the other group received Flurbiprofen 0.25% Oral spray. The pain was assessed postoperatively by Visual Analog Scale (VAS). The edema evaluation was measured on preoperative and postoperative 2nd and 7th days. Gastrointestinal adverse effects related to the use of nonsteroidal anti-inflammatory drug such as nausea, heartburn, dyspepsia, vomiting, and diarrhea were recorded according to information received from patients.
Results: There was a statistically significant difference between the groups with regard to Visual Analog Scale levels at 6th, 8th, 12th, 24th, and 48th hours. 2nd-day edema measurements of the systemic nonsteroidal anti-inflammatory drug group were found to be statistically lower than the local-topical nonsteroidal anti-inflammatory drug group.
Conclusion: Although the efficacy of topical nonsteroidal anti-inflammatory drugs on pain and edema is lower than systemic nonsteroidal anti-inflammatory drugs, it may be preferred because it has less gastrointestinal side effects.

Keywords

Pain,edema,third molar teeth

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Ahmet Taylan Çebi ^*
0000-0001-9083-7215
Türkiye

Yayımlanma Tarihi

31 Mart 2020

Gönderilme Tarihi

9 Ekim 2019

Kabul Tarihi

27 Kasım 2019

Yayımlandığı Sayı

Yıl 1970 Cilt: 45 Sayı: 1

DOI

https://doi.org/10.17826/cumj.631371

IZ

https://izlik.org/JA87TF34NJ

MLA

Çebi, Ahmet Taylan. “Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects”. Cukurova Medical Journal, c. 45, sy 1, Mart 2020, ss. 141-7, doi:10.17826/cumj.631371.

Cited By

A systematic review of flurbiprofen 8.75 mg dose and risk of adverse events (excluding haemorrhagic) resulting from drug-drug interactions

Frontiers in Pharmacology

https://doi.org/10.3389/fphar.2024.1107185

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Topikal ve sistemik flurbiprofenin gömülü üçüncü molar cerrahisi sonrası ağrı ve ödem üzerine etkilerinin ve gastrointestinal yan etkilerinin karşılaştırılması

Öz

Anahtar Kelimeler

Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

A systematic review of flurbiprofen 8.75 mg dose and risk of adverse events (excluding haemorrhagic) resulting from drug-drug interactions