Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects
Abstract
Purpose: The aim of this study was to evaluate the effects of systemic and topical nonsteroidal anti-inflammatory agents on postoperative pain and edema and also gastrointestinal side effects after impacted third molar surgery.
Materials and Methods: In this clinical study, 100 healthy patients with mandibular impacted third molar teeth in a similar position were included. After the operation, patients were divided into two groups, one group received Flurbiprofen tablets and the other group received Flurbiprofen 0.25% Oral spray. The pain was assessed postoperatively by Visual Analog Scale (VAS). The edema evaluation was measured on preoperative and postoperative 2nd and 7th days. Gastrointestinal adverse effects related to the use of nonsteroidal anti-inflammatory drug such as nausea, heartburn, dyspepsia, vomiting, and diarrhea were recorded according to information received from patients.
Results: There was a statistically significant difference between the groups with regard to Visual Analog Scale levels at 6th, 8th, 12th, 24th, and 48th hours. 2nd-day edema measurements of the systemic nonsteroidal anti-inflammatory drug group were found to be statistically lower than the local-topical nonsteroidal anti-inflammatory drug group.
Conclusion: Although the efficacy of topical nonsteroidal anti-inflammatory drugs on pain and edema is lower than systemic nonsteroidal anti-inflammatory drugs, it may be preferred because it has less gastrointestinal side effects.
Keywords
References
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