Ovarian granulosa cell tumor invasive to sigmoid colon causing acute intraabdominal hemorrhage: a rare case of acute abdomen

Yıl 2019, Cilt: 44 Sayı: Ek 1, 571 - 575, 29.12.2019

Osman Erdoğan , Zafer Teke Sevtap Seyfettinoğlu , Mevlüt Harun Ağca

https://doi.org/10.17826/cumj.556952

Öz

Granulosa cell tumor of the ovary is one of the sex cord stromal tumors of the ovary and often has the ability to secrete sex steroids such as estrogen. In our article, we present a 48-year-old female patient with abdominal pain and weakness who admitted to our emergency service and showed acute abdomen on physical examination preoperatively. Magnetic resonance imaging revealed a cystic lesion with dimensions of 56x55 mm in the left adnexal region, and a mass lesion with cystic and solid components within the abdomen and pelvis. After the surgical exploration, a cystic tumorous mass of left ovary which penetrated sigmoid colon causing intraabdominal hemorrhage was detected. We performed an anterior resection and bilateral salpingo-oophorectomy. Histopathological examination revealed a granulosa cell tumor of left ovary invasive to sigmoid colon. In this case report, clinical appearance of a case of granulosa cell tumor of the ovary is reviewed according to view of the literature.

Anahtar Kelimeler

Ovarian granulosa cell tumor, Sigmoid mesocolon, Intra-abdominal hemorrhage, Acute abdomen

Sigmoid kolonu invaze ederek akut karın içi kanamaya yol açmış over granüloza hücreli tümörü: nadir bir akut karın olgusu

Öz

Granüloza hücreli tümör, seks kord stromal kaynaklı, nadir görülen ve sıklıkla östrojen gibi seks steroidleri sentezleyebilen bir over tümörüdür. Bu çalışmada, kırk sekiz yaşında karın ağrısı ve genel durum bozukluğu nedeniyle acil servisimize başvuran ve preoperatif dönemde yapılan karın muayenesinde akut karın tablosu mevcut olan bir bayan hastayı sunuyoruz. Hastaya çekilen manyetik rezonans (MR) görüntülemede, sol adneksiyal alanda 56x55 mm boyutlarında kistik lezyon ve karın ve pelvis içinde solid ve kistik alanlar içeren kitlesel lezyon izlendi. Hastamızın cerrahi eksplorasyon sonrası sol overinde sigmoid kolonu penetre ederek akut karın içi kanamaya yol açmış kistik tümöral kitle tespit edildi. Biz olgumuza anterior rezeksiyon ve bilateral salpingo-ooferektomi uyguladık. Histopatoloji sonucu sigmoid kolonu invaze etmiş sol overde granüloza hücreli tümör saptanmıştır. Bu olgu sunumunda, overin granüloza hücreli tümör vakası ve klinik görünümü literatür verileri ışığında gözden geçirildi.

Anahtar Kelimeler

Overin granüloza hüceli tümörü, Sigmoid mezokolon, Karın içi kanama, Akut karın

Kaynakça

• 1. Fink D, Kubik-Huch RA, Wildermuth S. Juvenile granulosa cell tumor. Abdom Imaging. 2001;26:5502-3.
• 2. Calaminus G, Wessalowski R, Harms D, Göbel U. Juvenile granulosa cell tumor of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study. Gynecol Oncol. 1997;65:447–42.
• 3. Kim SH. Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. J Comp Assist Tomogr.. 2002;26:756-61.
• 4. Cronjé HS, Niemand I, Bam RH, Woodruff JD. Review of the granulosa-theca cell tumors from the emil Novak ovarian tumor registry. Am J Obstet Gynecol. 1999;180:323-7.
• 5. Marikowa K, Hatabu H, Togashi K, Kataoka ML, Mori T, Konishi J. Granulosa cell tumor of the ovary: MR findings. J Comput Assist Tomogr. 1997;21:1001-4.
• 6. Fox H, Agrawal K, Langley FA. A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer. 1975;35:231–41.
• 7. Stenwig JT, Hazekamp JT, Beecham JB. Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long-term follow-up. Gynecol Oncol. 1979;7:136–52.
• 8. Evans AT 3rd, Gaffey TA, Malkasian GD Jr, Annegers JF. Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol. 1980;55:231–8.
• 9. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1995. A 56-year-old woman with abdominal pain, anemia, and a pelvic mass. N Engl J Med. 1995;332:876–81.
• 10. Demas BE, Hricak H, Jaffe RB. Uterine MR imaging: effects of hormonal stimulation. Radiology. 1986;159:123-6.
• 11. Ko SF, Wan YL, Ng SH. Adult ovarian granulosa cell tumors: spectrum of sonographic and CT findings with patologic correlation. AJR Am J Roentgenol. 1999;172:1227-33.
• 12. Stein M, Koenigsberg M, Han M. US case of the day. Adult-type granulosa cell tumor. Radiographics. 1996;16:200-3.
• 13. Cannistra SA. Cancer of the ovary. N Engl J Med. 1993;329:1550-9.
• 14. Malmström H, Högberg T, Risberg B, Simonsen E. Granulosa cell tumors of the ovary: prognostic factors and outcome. Gynecol Oncol. 1994;52:50–5.
• 15. Fujimoto T, Sakuragi N, Okuyama K, Fujino T, Yamashita K, Yamashiro S, et al. Histopathological prognostic factors of adult granulosa cell tumors of the ovary. Acta Obstet Gynecol Scand. 2001;80:1069-74.
• 16. Fletcher JA, Gibas Z, Donovan K, Perez-Atayde A, Genest D, Morton CC, et al. Ovarian granulosa-stromal cell tumors are characterized by trisomy 12. Am J Pathol. 1991;138:515-20.
• 17. Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clinc Oncol. 2003;21:1180-9.
• 18. Hines JF, Khalifa MA, Moore JL, Fine KP, Lage JM, Barnes WA. Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol 1996;60:484-8.