Corpus Callosum Agenesis Presented With Attention Deficit Hyperactivity Disorder: Two Case Reports

Year 2013, Volume: 38 Issue: 4, 759 - 764, 01.12.2013

Musa Şahpolat Gonca Çelik Ayşe Avcı Ayşegül Tahiroğlu

Abstract

ADHD is a treatable neuropsychiatric disorder which can continue till adulthood. There have been three subtypes including attention deficiency, hyperactivity and impulsivity. Its etiology remains unclear yet. It is hypothesized that there is an impairment of neurodevelopment in early developmental periods through the interactions between genetic and environmental processes. Corpus callosum provides an integration of cognitive, sensorial and motor functions of brain as a response to the impulses originating from the cortex. The damage of this region may result in deterioration of some cerebral functions such as cognitive functions, speaking, learning ability and impulse control. In this paper, we report two pediatric cases who had comorbid attention deficiency and corpus callosum agenesis without mental retardation.

Keywords

Attention Deficit Hyperactivity Disorder, Corpus Callosum Agenesis

Dikkat Eksikliği Hiperaktivite Bozukluğu İle Prezente Olan Corpus Callosum Agenezisi: İki Olgu Bildirimi

Abstract

ÖZET: Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) erişkin hayatta da devam edebilen, tedavi edilebilir nöropsikiyatrik bir bozukluktur. Dikkat eksikliği, aşırı hareketlilik ve dürtüsellikle karakterize üç alt tipi bulunmaktadır. DEHB, etiyolojisi halen yeterince aydınlatılamamış bir alandır. DEHB de erken gelişim evrelerinde, çeşitli genetik ve çevresel etkenlerin etkileşimiyle, nörogelişimde bir aksama olduğu öne sürülmektedir. Korpus kallozum, korteksten köken alan uyaranları karşı taraf hemisfere bağlayarak beynin motor, duyusal ve kognitif performansını sağlamaktadır. Bu bölgede meydana gelen bir hasar kognitif beceriler, konuşma, ögrenme ve dürtü kontrol gibi beyin fonksiyonlarında bozulmaya neden olabilir. Bu yazıda; ilk ruhsal belirtileri dikkat eksikliği ve hiperaktivite olan iki çocuk olgudaki, korpus kallozum agenezisi ve DEHB birlikteliğinin olası patofizyolojik mekanizmaları tartışılmaktadır.

Keywords

Dikkat Eksikliği Hiperaktivite Bozukluğu, Korpus Kallozum Agenezisi

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• Yazışma Adresi / Address for Correspondence: Dr. Gonca Çelik Çukurova Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı 01330 Balca lı-ADANA e-mail: [e-mail] geliş tarihi/received :15.02.2013 kabul tarihi/accepted:29.03.2013