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Cough Syncope due to ACE Inhibitor

Year 2015, Volume: 40 Issue: 3, 619 - 622, 01.10.2015
https://doi.org/10.17826/cutf.00454

Abstract

Syncope is defined as a transient loss of consciousness due to sudden temporary decline in cerebral perfusion. Cough syncope is classically seen in middle aged obese men with obstructive pulmonary disease. In patients that use Angiotensin converting enzyme (ACE) inhibitors, a dry persistent cough can emerge due to the side effects of this medication. Seventy years old male patient that use ACE inhibitor for hypertension accepted to the clinic with the complaint of syncope. A bout of coughing has developed during electroencephalography recording and 10 seconds in duration of subcortical like epileptiform discharges were viewed. The ACE inhibitor the patient was receiving was replaced with calcium channel blocker and no complaint was observed during the follow up period.

References

  • Chung CP, Cheng CY, Zivadinov R, Chen WC, Sheng WY, Lee YC, Hu HH, Hsu HY, Yang KY. Jugular venous reflux and plasma endothelin-1 are associated with cough syncope: a case control pilot study; BMC Neurol. 2013;16;13:9.
  • Krediet CT, Wieling W. Edward P. Sharpey Schafer was right: evidence for systemic vasodilatation as a mechanism of Europace. 2008;10:486-8. syncope;
  • Omboni S, Borghi C. Zofenopril and incidence of cough: a review of published and unpublished data. Ther Clin Risk Manag; 2011;7:459–71.
  • Kułakowski P. Syncope update 2013: diagnosis and
  • treatment; Kardiol Pol. 2013;71:215-23.
  • Gould PA, Krahn AD, Klein GJ, Yee R, Skanes AC, Gula LC. Syncope: A review. Current Opinion in Cardiology. 2006;21:34–41.
  • Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D. Incidence and prognosis of syncope. N Engl J Med. 2002;347:878- 85.
  • Brignole M, Alboni P, Benditt DG, Bergfeldt L, Blanc JJ, Thomsen PE, Gert van Dijk J, et al. Task Force on European Syncope, Society of Kaohsiung J Med Sci.
  • El-Osta H, Ashfaq S. Cough-Induced Syncope as an Unusual Manifestation of Pericardial Effusion; Kansas Journal of Medicine. 2008;1:53-5.
  • Benditt DG, Samniah N, Pham S, Sakaguchi S, Lu F, Lurie KG, Ermis C. Effect of cough on heart rate and blood pressure in patients with "cough syncope"; Heart Rhythm. 2005;2:807-13.
  • Ariturk Z, Alici H, Cakici M, Davutoglu V. A rare cause of syncope: cough. Eur Rev Med Pharmacol Sci. 2012;16uppl 1:71-2.
  • Stec S, Dabrowska M, Zaborska B, Bielicki P, Maskey-Warzechowska M, Tarnowski W, et al. Premature ventricular complex-induced cough and cough syncope; Eur Respir J. 2007; 30:391-4. chronic

ACE İnhibitörüne Bağlı Öksürük Senkopu

Year 2015, Volume: 40 Issue: 3, 619 - 622, 01.10.2015
https://doi.org/10.17826/cutf.00454

Abstract

Senkop, serebral perfüzyonun aniden geçici olarak düşmesiyle ortaya çıkan geçici bilinç kaybı olarak tanımlanır. Obstrüktif akciğer hastalığı olan orta yaşlı obez erkeklerde öksürüğe bağlı senkop klasik olarak görülmektedir. Anjiyotensin konverting enzim (ACE) inhibitörü kullanan hastalarda bu ilacın yan etkisi olarak kalıcı kuru öksürük görülebilmektedir. Hipertansiyon tedavisi için ACE inhibitörü kullanan yetmiş yaşındaki erkek hasta senkop şikayeti ile kliniğe kabul edildi. Elektroensefalografi kaydı sırasında bir öksürük nöbeti gelişti ve süresi 10 saniye olan subkortikal benzeri epileptiform deşarjlar görüldü. Hastanın kullandığı ACE inhibitörü kalsiyum kanal blokörleri ile değiştirildiğinde takip periyodunda herhangi bir komplikasyona rastlanmadı.

References

  • Chung CP, Cheng CY, Zivadinov R, Chen WC, Sheng WY, Lee YC, Hu HH, Hsu HY, Yang KY. Jugular venous reflux and plasma endothelin-1 are associated with cough syncope: a case control pilot study; BMC Neurol. 2013;16;13:9.
  • Krediet CT, Wieling W. Edward P. Sharpey Schafer was right: evidence for systemic vasodilatation as a mechanism of Europace. 2008;10:486-8. syncope;
  • Omboni S, Borghi C. Zofenopril and incidence of cough: a review of published and unpublished data. Ther Clin Risk Manag; 2011;7:459–71.
  • Kułakowski P. Syncope update 2013: diagnosis and
  • treatment; Kardiol Pol. 2013;71:215-23.
  • Gould PA, Krahn AD, Klein GJ, Yee R, Skanes AC, Gula LC. Syncope: A review. Current Opinion in Cardiology. 2006;21:34–41.
  • Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D. Incidence and prognosis of syncope. N Engl J Med. 2002;347:878- 85.
  • Brignole M, Alboni P, Benditt DG, Bergfeldt L, Blanc JJ, Thomsen PE, Gert van Dijk J, et al. Task Force on European Syncope, Society of Kaohsiung J Med Sci.
  • El-Osta H, Ashfaq S. Cough-Induced Syncope as an Unusual Manifestation of Pericardial Effusion; Kansas Journal of Medicine. 2008;1:53-5.
  • Benditt DG, Samniah N, Pham S, Sakaguchi S, Lu F, Lurie KG, Ermis C. Effect of cough on heart rate and blood pressure in patients with "cough syncope"; Heart Rhythm. 2005;2:807-13.
  • Ariturk Z, Alici H, Cakici M, Davutoglu V. A rare cause of syncope: cough. Eur Rev Med Pharmacol Sci. 2012;16uppl 1:71-2.
  • Stec S, Dabrowska M, Zaborska B, Bielicki P, Maskey-Warzechowska M, Tarnowski W, et al. Premature ventricular complex-induced cough and cough syncope; Eur Respir J. 2007; 30:391-4. chronic
There are 12 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Ayşe Koç This is me

Mehmet Peköz This is me

Hacer Bozdemir This is me

Publication Date October 1, 2015
Published in Issue Year 2015 Volume: 40 Issue: 3

Cite

MLA Koç, Ayşe et al. “Cough Syncope Due to ACE Inhibitor”. Cukurova Medical Journal, vol. 40, no. 3, 2015, pp. 619-22, doi:10.17826/cutf.00454.