Relationship between umbilical cord blood vitamin D levels and thymus size in healthy and term newborns

Yıl 2019, Cilt: 44 Sayı: 4, 1450 - 1455, 29.12.2019

Selvi Gülaşı Mustafa Kurthan Mert Gökhan Söker Ümit Çelik

Öz

Purpose: Thymus is a primary lymphoid organ which contains the vitamin D receptor. Vitamin D has an immunological regulatory effect on the adaptive and innate immune system. The aim of this study was to determine the relationship between cord blood 25-hydroxy vitamin D levels and thymus size.

Materials and Methods: 149 babies were included in the present study. The cord blood 25-hydroxy vitamin D level was measured. Mothers’ and infants’ features were recorded. Thymus volume were evaluated with ultrasonography. The thymic index and thymus/weight index were calculated. 

Results: In the case of irregular use or non-use of maternal vitamin D, the likelihood of vitamin D deficiency in the cord blood was higher. No difference was observed between the thymic index measurements and maternal vitamin D use and cord blood vitamin D level.

Conclusion: There was no relationship between cord blood vitamin D level and thymus size.

Anahtar Kelimeler

newborn, thymus, ultrasonography, vitamin D

Sağlıklı term yenidoğanlarda umbilikal kord kanında D vitamini düzeylerinin timus büyüklüğü ile ilişkisi

Öz

Amaç: Timus vitamin D reseptörü içeren primer bir lenfoid organdır. D vitamini adaptif ve doğal immün system üzerine düzenleyici etkilere sahiptir. Bu çalışmanın amacı kord kanı 25-hidroksi vitamin D düzeyi ile timus büyüklüğü arasındaki ilişkiyi tanımlamaktır.

Gereç ve Yöntem: Çalışmaya 149 bebek alındı. Kord kanı 25-hidroksi vitamin D düzeyleri ölçüldü. Annelerin ve bebeklerin özellikleri kaydedildi. Timus büyüklüğü ultrasonografi ile değerlendirildi. Timik indeks ve timus/ağırlık indeksi hesaplandı.

Bulgular: Annenin D vitaminini düzensiz kullanması veya kullanmaması durumunda kord kanında D vitamin eksikliği olasılığını daha yüksekti. Timik indeks ile annenin vitamin kullanımı ve kord kanı D vitamini düzeyi ile timik indeks arasında ilişki saptanmadı.

Sonuç: Kord kanı D vitamini düzeyi ile timik indeks arasında ilişki saptanmamıştır.

Anahtar Kelimeler

yenidoğan, timus, ultrasonografi, vitamin D

Kaynakça

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