Akromegali hastalarında üst gastrointestinal system endoskopi taramasının değerlendirilmesi: tek merkez deneyimi

Yıl 2023, Cilt: 48 Sayı: 1, 145 - 152, 31.03.2023

Yasemin Emür Günay Serdar Durak Ozge Üçüncü Arif Mansur Coşar

https://doi.org/10.17826/cumj.1162996

Öz

Amaç: Akromegalik hastalarda üst gastrointestinal sistemdeki prekanser öz veya kanserlilezyonların prevalansıiyi bilinmemektedir. Çalışmamızda Akromegali hastalarının üst gastrointestinal sistem(GİS) endoskopi bulgularının incelenmesi ve patolojik bulguların hastalık ve somatostatin analoğu kullanımı ile ilişkisinin olupol madığının değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Ocak 2010 ile Ekim 2021 arasında akromegali tanısı konulan hastalar tıbbi kayıtlar geriye dönük taranarak belirlendi. Bu çalışmayaüst GİS endoskopisiyapılan 49 akromegali hastası dahil edildi. Akromegali hastaları endoskopi anında somatostatin analogu kullanan ve kullanmayanlar olarak iki gruba ayrıldı. Bu iki grup arasında lezyon gelişimi açısından fark olup olmadığı incelendi. Akromegali hastaları ve control grubu endoskopik bulgular ve biyopsi sonuçları açısından karşılaştırıldı.
Bulgular: Hastaların %53'ü (n=26) erkek, %46,9'u (n=23) kadındı. Akromegali hastalarında Helicobakterpilori (HP) insidansı kontrollere göre anlamlı derecede yüksekti. Akromegali grubunda antral ve pangastriti olan 24 hastanın %62,5'i (n=15) somatostatin analoglarıalıyordu. Somatostatin analoglarının kullanımı ile gastrit gelişimi arasında anlamlı bir fark yoktu. Somatostatin analogları kullanan akromegali hastalarında özofajit gelişimi istatistiksel olarak daha yüksek saptandı.
Sonuç: Akromegali hastalarında HP görülmesıklığı normal popülasyona göre yüksek saptanmıştır. Gastrit gelişiminde ise net sonuçlar ortaya konamamıştır. Somatostatin analogları kullananak romegali hastalarında özofajit sıklığı yüksek bulundu. Etyolojisinin hastalık ve kullanılan ilaçlarla ilişkisinin net bir şekilde ortaya konulabilmesi açısından geniş çaplı çalışmalara gereksinim duyulmaktadır.

Anahtar Kelimeler

Akromegali, Özofajit, Somatostatin analogları, Üst Gastrointestinal Sistem Endoskopisi.

Evaluation of upper gastrointestinal system endoscopy screening in patients with acromegaly: a single center experience

Öz

Purpose: The prevalence of precancerous or cancerous lesions in the upper gastrointestinal tract in acromegalic patients is not well known. The aim of this study is to evaluate the endoscopic findings of the upper gastrointestinal system (GIS) of patients with acromegaly and to assess whether the pathological findings are related to the disease and the use of somatostatin analogs.
Materials and Methods: Between January 2010 and October 2021, patients diagnosed with acromegaly were identified by retrospective medical record scanning. This study included 49 patients with acromegaly who underwent upper GIS endoscopy. The acromegaly patients were divided into two groups: those who were taking somatostatin analogs at the time of endoscopy and those who were not. It was investigated whether there was a difference between these two groups in terms of lesion development. The patients with acromegaly and the control group were compared in terms of endoscopic findings and biopsy results.
Results: Of these patients, 53% (n=26) were male and 46.9% (n=23) were female. The incidence of Helicobacter pylori (HP) was significantly higher in the acromegaly patients than in the control subjects. In the acromegaly group, 62.5% (n=15) of the 24 patients with antral and pangastritis were taking somatostatin analogs. There was no significant difference between the use of somatostatin analogs and the development of gastritis. The development of esophagitis was statistically higher in patients with acromegaly taking somatostatin analogs.
Conclusion: The incidence of HP was higher in patients with acromegaly than in the normal population. No clear results were found regarding the development of gastritis. The incidence of esophagitis was high in acromegalic patients taking somatostatin analogs. Large-scale studies are needed to uncover the relationship between the etiology of the disease and the drugs taken.

Anahtar Kelimeler

Acromegaly, Esophagitis, Somatostatin analogs, Upper Gastrointestinal System Endoscopy.

Kaynakça

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