A neuroimaging study of altered cortical and subcortical volume in adolescent methamphetamine users

Year 2023, Volume: 48 Issue: 3, 1148 - 1156, 30.09.2023

Zekeriya Temircan

https://doi.org/10.17826/cumj.1349328

Cited By: 1

Abstract

Purpose: The aim of this study was is to compare brain structure volume, including cortical and subcortical regions of adolescents- methamphetamine users versus non-users.
Materials and Methods: The study was designed to be cross-sectional, and structural magnetic resonance imaging scans were obtained from the participants, including ten methamphetamine users and nine non-users. volBrain program was used to evaluate the images.
Results: The results showed that methamphetamine users altered brain structures- temporal, parietal lobes, nucleus accumbens, amygdala, hippocampus, and thalamus volume. Also, the statistically significant difference in the volume between methamphetamine users and non-users was found in subcortical regions except putamen by age. Volumetric analysis of methamphetamine use in adolescents confirms a reduction in temporal lobes (methamphetamine users M±SD=3.43±0.18 non-users M±SD=3.48±0.22) and parietal lobes (methamphetamine users M±SD=2.23±0.24, non-users M±SD=2.37±0.33) in cortical regions in the brain as tissue volume. However, methamphetamine uses caused an increase in volume in the subcortical regions.
Conclusion: Methamphetamine use appears to show decreased volume in the brain regions with age, which has adverse effects on cognitive, emotional, memory, and social abilities.

Keywords

Methamphetamine, brain volume, adolescent, cortical, subcortical regions

Project Number

KÜN.2022-BAGP-017

Metamfetamin kullanan ergenlerin kortikal ve subkortikal beyin hacim değişimlerinin nörogörüntüleme çalışması

Abstract

Amaç: Bu çalışma metamfetamin kullanan ve kullanmayan ergenlerin beyin kortikal ve subkortikal bölgeleri dahil olmak üzere beyin yapı hacimlerini karşılaştırmayı amaçlamıştır.
Gereç ve Yöntem: Kesitsel olarak tasarlanan bu çalışmaya on metamfetamin kullanan ve dokuz metamfetamin kullanmayan ergenler dahil edilmiştir. Katılımcıların beyin görüntüleri magnetik rezonans görüntüleme cihazı ile elde edilmiş ve görüntülerin analizi volBrain program aracılığıyla yapılmıştır.
Bulgular: Sonuçlar metamfetamin kullanıcılarının temporal, parietal, nükleus akkumbens, amigdala, hipokampüs ve talamus bölgelerinde hacimsel değişikler olduğunu göstermiştir. Ayrıca, metamfetamin kullanan ve kullanmayanların subkortikal bölgelerinde, putamen bölgesi dışında, hacimsel değişikliğin yaşa göre istatistiksel anlamlılık gösterdiği bulunmuştur. Ergenlerde metamfetamin kullanımına ilişkin hacimsel analiz sonucunda temporal lobda (metamfetamin kullananlar M±SD=3.43±0.18, kullanmayanlar M±SD=3.48±0.22) ve parietal lobda (metamfetamin kullananlar M±SD=2.23±0.24, kullanmayanlar M±SD=2.37±0.33) hacimsel azalma olduğunu tespit edilmiştir. Ancak metamfetamin kullanımı subkortikal bölgelerde hacim artışına neden olmuştur.
Sonuç: Metamfetamin kullanımın yaşa bağlı olarak beyin bölgelerinde hacimsel değişime neden olduğu, bununla beraber kullanıcıların bilişsel, duygusal, hafıza ve sosyal becerileri üzerinde olumsuz etkiler oluşturduğu söylenebilir.

Keywords

Metamfetamin, Beyin hacmi, Ergen, Kortikal, Subkortikal bölgeler

Supporting Institution

Kapadokya Üniversitesi

Project Number

KÜN.2022-BAGP-017

Thanks

Çalışmaya destek veren Prof. Dr. Müge Artar ve Erciyes Üniversitesi Radyoloji Ana bilim dalı öğretim üyeleri Prof. Dr. Halil Sönmez ve Dr. Öğr. Üyesi İzzet Ökçesiz ile Öğr. Gör. Hüseyin Yiğit e teşekür ederim.

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