FYL-2020-12800
This study was carried out to reveal the in vitro cytogenotoxic effect of 2-amino-5-(6-bromo-2-oxo-2H-chromen-3-yl) selenophene-3-carbonitrile (6-BrCoumSel or CoumSel), a newly synthesized coumarin-selenophene hybrid compound. Coumarin (2H-chromen-2-one), one of the main components of the test substance hybrid molecule (CoumSel), is an aromatic organic chemical compound with the formula C9H6O2. Pharmacologically, coumarin belongs to the flavonoid group of chemicals. The other component, selenophene, has the formula C4H4Se and is an unsaturated organic compound containing a five-membered ring containing selenium in its structure. It is a colorless liquid and is one of the most common selenium heterocycles. It was found that in human lymphocytes cultured in vitro, the hybrid CoumSel compound increased the frequency of chromosome abnormalities (CA) and micronuclei (MN), especially at high concentrations, compared to the untreated group (0 µg/ml). The potential of CoumSel as an antiproliferative drug with its current properties should not be ignored.
Coumarin-selenophene hybrid compound in vitro human lymphocyte chromosome aberration
FYL-2020-12800
Birincil Dil | İngilizce |
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Konular | Hücre Gelişimi, Proliferasyon ve Ölümü |
Bölüm | Research Articles |
Yazarlar | |
Proje Numarası | FYL-2020-12800 |
Yayımlanma Tarihi | 30 Haziran 2024 |
Gönderilme Tarihi | 14 Şubat 2024 |
Kabul Tarihi | 8 Mart 2024 |
Yayımlandığı Sayı | Yıl 2024 Cilt: 3 Sayı: 1 |