Amelioration of External Surgical Wound by Topical Application of the Aqueous Formulation of Neem Leaves (Azadirachta indica) in Caprine Model

Yıl 2020, Cilt: 3 Sayı: 2, 87 - 96, 24.12.2020

Ajmary Sultana , Marzia Rahman , Md. Mahmudul Alam

https://doi.org/10.38093/cupmap.828751

Öz

The study was conducted to evaluate the healing potentials of Neem leaf on surgical wounds. A total of sixteen surgical wounds were studied under two groups; Neem (group A) and Normal saline (group B, control). Wound morphology, histopathology, and bacteriological examinations were carried out to assess wound healing potentials of this plant leaves. We have found a remarkably lower swollen area (3.91±0.10mm), suture line levation (2.64±0.19mm) and length of the wound (15.78±0.19mm) in the treatment group than the control (0.36±0.12mm, 3.59±0.12mm, and 17.11±0.08mm respectively). The mean healing period Neem treated wound was significantly (P<0.05) lower (12.33±0.42 days) than that of control (18.67±0.33 days). Histopathological study revealed the presence of substantial inflammation with fibroblastic proliferation in samples collected at day 3 in the control group whereas these features were distinctly reduced in the treatment group. There was a distinct thickening of the keratinized layer of the epidermis in Neem treated wound on day 21. In bacteriological study, huge bacterial colonies were found on day 3 in the control group whereas this was markedly reduced in number in the wound of Group-A. Thus, the present study supports the scientific rationale for the use of Neem leaf in the management of wounds.

Anahtar Kelimeler

Neem leaf, Surgical wound, Histopathology, Bacteriology, Amelioration

Kaynakça

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