Fiziksel Aktivite Düzeyine Göre Direnç Egzersizlerinin Kardiyorespiratuvar ve Kardiyometabolik Adaptasyonları

Öz

Bu derleme çalışması, fiziksel aktivite düzeyine göre direnç egzersizlerinin kardiyorespiratuvar ve kardiyometabolik adaptasyonlar üzerindeki etkilerini incelemektedir. Direnç egzersizleri (DE), kas kuvveti ve kütlesini artırmasının yanı sıra, insülin duyarlılığı, kan basıncı ve lipid profili gibi kardiyometabolik göstergelerde iyileşmelere katkı sağlamaktadır. Ancak bu etkilerin büyüklüğü, bireylerin başlangıç fiziksel aktivite düzeyine ve antrenman protokolüne göre değişmektedir. Sporcularda DE, performans odaklı kazanımlar (kuvvet, güç, kas dayanıklılığı) sağlar, fakat kardiyorespiratuvar kapasitedeki artışlar genellikle sınırlıdır. Buna karşın, sedanter bireylerde DE; VO₂max, glukoz metabolizması, vücut kompozisyonu ve kan basıncı üzerinde anlamlı iyileşmeler oluşturur. Ayrıca, haftalık 2–3 seanslık orta yoğunluklu programların kardiyometabolik risk faktörlerini azaltmada etkili olduğu görülmektedir. Mevcut kanıtlar, DE’nin hem sağlık hem performans için temel bir araç olduğunu, ancak etkilerin bireysel özelliklere ve antrenman parametrelerine göre farklılaştığını göstermektedir. Daha uzun süreli ve doğrudan karşılaştırmalı çalışmalar, bu adaptasyonların sürdürülebilirliğini ve fiziksel aktivite düzeyine göre farklılaşma mekanizmalarını aydınlatmak açısından gereklidir.

Anahtar Kelimeler

• Direnç egzersizi
• Fiziksel Aktivite
• kardiyometabolik adaptasyonlar

Cardiorespiratory and Cardiometabolic Adaptations to Resistance Exercise According to Physical Activity Level

Öz

This review examines the effects of resistance exercise (RE) on cardiorespiratory and cardiometabolic adaptations according to physical activity level. Resistance exercise not only improves muscular strength and mass but also contributes to favorable changes in insulin sensitivity, blood pressure, and lipid profile. The magnitude of these effects varies depending on baseline physical activity and training protocols. In athletes, RE primarily enhances performance-related parameters (strength, power, muscular endurance), while increases in cardiorespiratory capacity are limited. Conversely, in sedentary individuals, RE significantly improves VO₂max, glucose metabolism, body composition, and blood pressure. Moderate-intensity RE programs performed two to three times per week appear effective in reducing cardiometabolic risk factors. Current evidence supports RE as a fundamental component of health and performance enhancement, although outcomes differ according to individual characteristics and training variables. Long-term and comparative studies are needed to clarify the sustainability of these adaptations and their dependence on physical activity level.

Anahtar Kelimeler

• Resistance training
• physical activity
• Cardiometabolic Adaptations

Kaynakça

1. Al-Mhanna, S. B., Franklin, B. A., Jakicic, J. M., Stamatakis, E., Pescatello, L. S., Riebe, D., ... & Batrakoulis, A. (2025). Impact of resistance training on cardiometabolic health-related indices in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis of randomised controlled trials. British journal of sports medicine, 59(10), 733-746.
2. Amekran, Y. (2024). Effects of exercise training on heart rate variability in healthy adults: a systematic review and meta-analysis of randomized controlled trials. Cureus, 16(6).
3. Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024). Exercise induces tissue-specific adaptations to enhance cardiometabolic health. Cell metabolism, 36(2), 278-300.
4. Bakker, E. A., Lee, D. C., Sui, X., Artero, E. G., Ruiz, J. R., Eijsvogels, T. M., ... & Blair, S. N. (2017, August). Association of resistance exercise, independent of and combined with aerobic exercise, with the incidence of metabolic syndrome. In Mayo Clinic Proceedings (Vol. 92, No. 8, pp. 1214-1222). Elsevier.
5. Belanger, M. J., Rao, P., & Robbins, J. M. (2022). Exercise, physical activity, and cardiometabolic health: Pathophysiologic insights. Cardiology in review, 30(3), 134-144.
6. Binmahfoz, A., Dighriri, A., Gray, C., & Gray, S. R. (2025). Effect of resistance exercise on body composition, muscle strength and cardiometabolic health during dietary weight loss in people living with overweight or obesity: a systematic review and meta-analysis. BMJ Open Sport & Exercise Medicine, 11(3).
7. Boyer, W., Toth, L., Brenton, M., Augé, R., Churilla, J., & Fitzhugh, E. (2023). The role of resistance training in influencing insulin resistance among adults living with obesity/overweight without diabetes: A systematic review and meta-analysis. Obesity research & clinical practice, 17(4), 279-287.
8. Chen, X., He, H., Xie, K., Zhang, L., & Cao, C. (2024). Effects of various exercise types on visceral adipose tissue in individuals with overweight and obesity: A systematic review and network meta‐analysis of 84 randomized controlled trials. Obesity Reviews, 25(3), e13666.

9. Correia, R. R., Veras, A. S. C., Tebar, W. R., Rufino, J. C., Batista, V. R. G., & Teixeira, G. R. (2023). Strength training for arterial hypertension treatment: a systematic review and meta-analysis of randomized clinical trials. Scientific reports, 13(1), 201.
10. Davitt, P. M., Pellegrino, J. K., Schanzer, J. R., Tjionas, H., & Arent, S. M. (2014). The effects of a combined resistance training and endurance exercise program in inactive college female subjects: does order matter?. The Journal of Strength & Conditioning Research, 28(7), 1937-1945.
11. De Oude, K. I., Elbers, R. G., Gerger, H., Maes-Festen, D. A., & Oppewal, A. (2025). The effect of different resistance exercise training intensities on cardiovascular risk factors: a systematic review and meta-analysis. European Heart Journal Open, 5(5), oeaf093.
12. Feng, W., Wang, F., Han, Y., & Li, G. (2024). RETRACTED: The effect of 12-week core strength training on dynamic balance, agility, and dribbling skill in adolescent basketball players. Heliyon, 10(6).
13. Fu, Y., Feng, Q., Wei, Y., Fan, L., Pan, Y., Ji, J., & Lin, C. (2022). Meta‐Analysis of the Effect of Aerobic Training on Blood Pressure in Hypertensive Patients. Computational and Mathematical Methods in Medicine, 2022(1), 9281661.
14. He, M., Hu, S., Wang, J., Wang, J., Găman, M. A., Hariri, Z., & Tian, Y. (2023). Effect of resistance training on lipid profile in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. European Journal of Obstetrics & Gynecology and Reproductive Biology, 288, 18-28.
15. Ho, S. S., Dhaliwal, S. S., Hills, A. P., & Pal, S. (2012). The effect of 12 weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a randomized trial. BMC public health, 12(1), 704.
16. Hughes, D. C., Ellefsen, S., & Baar, K. (2018). Adaptations to endurance and strength training. Cold Spring Harbor perspectives in medicine, 8(6), a029769.
17. Ignjatovic, A., Radovanovic, D., Stankovic, R., Marković, Z., & Kocic, J. (2011). Influence of resistance training on cardiorespiratory endurance and muscle power and strength in young athletes. Acta Physiologica Hungarica, 98(3), 305-312.
18. Janyacharoen, T., Thayon, M., Bushong, W., Jaikla, N., & Sawanyawisuth, K. (2016). Effects of resistance exercise on cardiopulmonary factors in sedentary individuals. Journal of Physical Therapy Science, 28(1), 213-217.
19. Jayedi, A., Soltani, S., Emadi, A., Zargar, M. S., & Najafi, A. (2024). Aerobic exercise and weight loss in adults: a systematic review and dose-response meta-analysis. JAMA Network Open, 7(12), e2452185-e2452185.
20. Lacio, M., Vieira, J. G., Trybulski, R., Campos, Y., Santana, D., Filho, J. E., ... & Wilk, M. (2021). Effects of resistance training performed with different loads in untrained and trained male adult individuals on maximal strength and muscle hypertrophy: A systematic review. International journal of environmental research and public health, 18(21), 11237.
21. Lanke Vani, M., Neeraja, M., & Rao, P. (2025). Cardiovascular Adaptations to Exercise: A Systematic Review of Molecular, Structural, and Functional Changes in Response to Different Training Modalities. European Journal of Cardiovascular Medicine, 15, 511-516.
22. Li, J., Li, J., & Lu, Y. (2021). Effects of resistance training on insulin sensitivity in the elderly: a meta-analysis of randomized controlled trials. Journal of Exercise Science & Fitness, 19(4), 241-251.
23. Lin, L. L. C., Chen, Y. J., Lin, T. Y., & Weng, T. C. (2022). Effects of resistance training intensity on heart rate variability at rest and in response to orthostasis in middle-aged and older adults. International journal of environmental research and public health, 19(17), 10579.
24. Lo, M. S., Lin, L. L., Yao, W. J., & Ma, M. C. (2011). Training and detraining effects of the resistance vs. endurance program on body composition, body size, and physical performance in young men. The Journal of Strength & Conditioning Research, 25(8), 2246-2254.
25. Lopez, P., Taaffe, D. R., Galvão, D. A., Newton, R. U., Nonemacher, E. R., Wendt, V. M., ... & Rech, A. (2022). Resistance training effectiveness on body composition and body weight outcomes in individuals with overweight and obesity across the lifespan: A systematic review and meta‐analysis. Obesity Reviews, 23(5), e13428.
26. Miller, T., Mull, S., Aragon, A. A., Krieger, J., & Schoenfeld, B. J. (2018). Resistance training combined with diet decreases body fat while preserving lean mass independent of resting metabolic rate: A randomized trial. International journal of sport nutrition and exercise metabolism, 28(1), 46-54.
27. Nemoto, Y., Satoh, T., Takahashi, T., Hattori, T., Konno, S., Suzuki, S., ... & Munakata, M. (2021). Effects of isometric handgrip training on home blood pressure measurements in hypertensive patients: a randomized crossover study. Internal Medicine, 60(14), 2181-2188.
28. Ratamess, N. A., Rosenberg, J. G., Kang, J., Sundberg, S., Izer, K. A., Levowsky, J., ... & Faigenbaum, A. D. (2014). Acute oxygen uptake and resistance exercise performance using different rest interval lengths: The influence of maximal aerobic capacity and exercise sequence. The Journal of Strength & Conditioning Research, 28(7), 1875-1888.
29. Shailendra, P., Baldock, K. L., Li, L. K., Bennie, J. A., & Boyle, T. (2022). Resistance training and mortality risk: a systematic review and meta-analysis. American journal of preventive medicine, 63(2), 277-285.
30. Smart, T. F., Doleman, B., Hatt, J., Paul, M., Toft, S., Lund, J. N., & Phillips, B. E. (2022). The role of resistance exercise training for improving cardiorespiratory fitness in healthy older adults: a systematic review and meta-analysis. Age and ageing, 51(6), afac143.
31. Tongwu, Y., & Chuanwei, D. (2025). The effectiveness of metabolic resistance training versus traditional cardio on athletic performance: a systematic review and meta-analysis. Frontiers in Physiology, 16, 1551645.
32. Vikmoen, O., Raastad, T., Ellefsen, S., & Rønnestad, B. R. (2020). Adaptations to strength training differ between endurance-trained and untrained women. European journal of applied physiology, 120(7), 1541-1549.
33. Wang, J., Fan, S., & Wang, J. (2025). Resistance training enhances metabolic and muscular health and reduces systemic inflammation in middle-aged and older adults with type 2 diabetes: a meta-analysis. Diabetes Research and Clinical Practice, 112941.