5-FLUOROURACIL IN THE TREATMENT OF ACTINIC KERATOSIS AND PHOTOAGING: A CASE WITH SEVERE LOCAL IRRITANT REACTION DURING TREATMENT

Abstract

In the treatment of actinic keratosis, various topical agents are used for treatment of field cancerization as well as lesional destructive treatments. In this case report,  it was aimed to present a photographic follow-up of a patient who developed severe local irritant reaction by usage of topical 5% fluorouracil but is very satisfied with the long-term anti-aging effect and to emphasize the place of 5-fluorouracil in photoaging treatment. Topical 5-Fluorouracil 5% cream therapy was recommended for widespread actinic keratosis lesions in a 67-year-old female patient who had previously undergone non-melanoma skin cancer surgery. On day 20 of treatment, a severe local irritant reaction developed. Severe local reactions were controlled by skin supportive therapy. It was observed that the patient does not have actinic keratosis recurrence in the second year following treatment, has significant improvement in photoaging and is satisfied with the treatment. Topical 5 fluorouracil treatment treats both actinic keratoses and field cancerization, prevents actinic keratoses from developing and simultaneously treats photoaging. Considering all this, topical 5-fluorouracil treatment, which is very economical, seems to be the treatment method that should be preferred in the treatment of actinic keratosis.

Keywords

• Actinic keratosis,5-fluorouracil,photoaging,irritation,side effect

Kaynakça

1. 1. Siegel JA, Korgavkar K, Weinstock MA. Current perspective on actinic keratosis: a review. Br J Dermatol. 2017;177:350-358.
2. 2. Ceilley RI. Mechanisms of action of topical 5-fluorouracil: review and implications for the treatment of dermatological disorders. J Dermatolog Treat. 2012;23:83-89.
3. 3. Pomerantz H, Hogan D, Eilers D, et al. Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial. JAMA Dermatol. 2015;151:952-960.
4. 4. Yentzer B, Hick J, Williams L, et al. Adherence to a topical regimen of 5-fluorouracil, 0.5%, cream for the treatment of actinic keratoses. Arch Dermatol. 2009;145:203-205.
5. 5. Sachs DL, Kang S, Hammerberg C, et al. Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. Arch Dermatol. 2009;145:659-966.