5-FLUOROURACIL IN THE TREATMENT OF ACTINIC KERATOSIS AND PHOTOAGING: A CASE WITH SEVERE LOCAL IRRITANT REACTION DURING TREATMENT

Yıl 2017, Cilt: 1 Sayı: 1, 8 - 13, 28.12.2017

Berna Aksoy Aslı Tatlıparmak Erol Koç

Öz

In the treatment of actinic keratosis, various topical
agents are used for treatment of field cancerization as well as lesional
destructive treatments. In this case report, 
it was aimed to present a photographic follow-up of a patient who
developed severe local irritant reaction by usage of topical 5% fluorouracil
but is very satisfied with the long-term anti-aging effect and to emphasize the
place of 5-fluorouracil in photoaging treatment. Topical 5-Fluorouracil 5%
cream therapy was recommended for widespread actinic keratosis lesions in a
67-year-old female patient who had previously undergone non-melanoma skin
cancer surgery. On day 20 of treatment, a severe local irritant reaction
developed. Severe local reactions were controlled by skin supportive therapy.
It was observed that the patient does not have actinic keratosis recurrence in
the second year following treatment, has significant improvement in photoaging
and is satisfied with the treatment. Topical 5 fluorouracil treatment treats
both actinic keratoses and field cancerization, prevents actinic keratoses from
developing and simultaneously treats photoaging. Considering all this, topical
5-fluorouracil treatment, which is very economical, seems to be the treatment
method that should be preferred in the treatment of actinic keratosis.

Anahtar Kelimeler

Actinic keratosis, 5-fluorouracil, photoaging, irritation, side effect

Kaynakça

• 1. Siegel JA, Korgavkar K, Weinstock MA. Current perspective on actinic keratosis: a review. Br J Dermatol. 2017;177:350-358.
• 2. Ceilley RI. Mechanisms of action of topical 5-fluorouracil: review and implications for the treatment of dermatological disorders. J Dermatolog Treat. 2012;23:83-89.
• 3. Pomerantz H, Hogan D, Eilers D, et al. Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial. JAMA Dermatol. 2015;151:952-960.
• 4. Yentzer B, Hick J, Williams L, et al. Adherence to a topical regimen of 5-fluorouracil, 0.5%, cream for the treatment of actinic keratoses. Arch Dermatol. 2009;145:203-205.
• 5. Sachs DL, Kang S, Hammerberg C, et al. Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. Arch Dermatol. 2009;145:659-966.