Treatment Management of Leptomeningeal and Brain Metastases as a First Reccurence Site in a Case with Germ Cell Testicular Tumor

Öz

Patients with testicular germ cell tumors (TGCT) usually presented with a testicular mass and retroperitoneal lymph nodes metastases, but brain and leptomeningeal metastases are rarely encountered in oncology practice. There are not any proven treatment options for relapsing TGCT with brain or leptomeningeal metastasis. We herein present a rare case of TGCT of brain and leptomeningeal metastasis as a first sign of recurrence with literature review.

Anahtar Kelimeler

• testicular germ cell tumor
• brain metastasis
• leptomeningeal metastasis

Kaynakça

1. 1. https://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-staging-of-testicular-germ-cell-tumors
2. 2. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin 2021; 71:7.
3. 3. Feldman, D.R., Lorch, A., Kramar, A. et al. Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options—An Analysis From the Global Germ Cell Cancer Group. J Clin Oncol. 2016.34, 345–351. https://doi.org/10.1200/JCO.2015.62. 7000.
4. 4. Hinton S, Catalano PJ, Einhorn LH, et al. Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial. Cancer 2003; 97:1869.
5. 5. Kalra, M., Adra, N., Hanna, N., Abonour, R., Einhorn, L.H., 2020. High‐dose chemotherapy plus peripheral blood stem cell transplantation for patients with relapsed germ cell tumors and active brain metastases. Cancer 126, 1202–1207. https://doi. org/10.1002/cncr.32628.
6. 6. Jeong YB. Wang KC. Phi JH. et al. A Case of Nongerminomatous Germ Cell Tumor with Fulminant Course Concomitant Leptomeningeal Metastasis Brain Tumor Res Treat 2016;4:21-25. http://dx.doi.org/10.14791/btrt.2016.4.1.21