Araştırma Makalesi
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Diagnostic role of platelet indices and leukocyte count in pseudothrombocytopenia

Yıl 2022, , 113 - 122, 30.08.2022
https://doi.org/10.18614/deutip.1174477

Öz

Pseudothrombocytopenia, immune thrombocytopenia, diagnosis, complete blood count indices

Kaynakça

  • 1. Jali AGP, Nkambule BB. Prevalence and etiology of moderate and severe thrombocytopenia in a tertiary and quaternary centre in KwaZulu-Natal. Afr J Lab Med. 2020;9(1):799. doi: 10.4102/ajlm.v9i1.799
  • 2. Hillman RS, Ault KA, Leporrier M, Rinder HM. Thrombocytopenia. Hematology in Clinical Practice, 5e. New York, NY: McGraw-Hill Medical; 2016.
  • 3. Berkman N, Michaeli Y, Or R, Eldor A. EDTA-dependent pseudothrombocytopenia: a clinical study of 18 patients and a review of the literature. Am J Hematol. 1991;36(3):195-201. doi: 10.1002/ajh.2830360307
  • 4. Lin J, Luo Y, Yao S, Yan M, Li J, Ouyang W, et al. Discovery and correction of spurious low platelet counts due to EDTA‐dependent pseudothrombocytopenia. J Clin Lab Anal. 2015;29(5):419-26. doi: 10.1002/jcla.21818
  • 5. Lau LG, Chng WJJT. Unnecessary transfusions due to pseudothrombocytopenia: Transfusion medicine illustrated. Transfusion. 2004;44(6):801. doi: 10.1111/j.1537-2995.2004.04009.x

Diagnostic role of platelet indices and leukocyte count in pseudothrombocytopenia

Yıl 2022, , 113 - 122, 30.08.2022
https://doi.org/10.18614/deutip.1174477

Öz

Objective: This study aimed to evaluate whether platelet indices and leukocyte count predict the diagnosis of Ethylene Diamine Tetra Acetic Acid induced pseudothrombocytopenia (EDTA-PTCP) and differ this entity from immune thrombocytopenia (ITP).
Methods: One-hundred and sixty-nine individuals (52 patients diagnosed with EDTA-PTCP, 52 patients with newly diagnosed ITP, and 65 healthy individuals) were included. Demographic data and complete blood count (CBC) indices were compared between groups retrospectively.
Results: Age and sex distribution were similar in all groups. Between EDTA-PTCP and ITP groups, no difference was found for absolute leukocyte, neutrophil, lymphocyte, and monocyte counts as well as hemoglobin level, red-cell distribution width (RDW), and platelet distribution width (PDW). The median mean platelet volume (MPV) of the ITP group was found to be higher than the control and EDTA-PTCP groups (p<0.001 and p=0.001, respectively, 95% confidence interval; 2.52-4.45 and 0.56-2.6).

Conclusion: The results support that low platelet count in CBC may be a false result due to EDTA. Thrombocytopenic patients who have no bleeding symptoms and with normal MPV should be evaluated for EDTA-PTCP. This evaluation can be made by a peripheral blood smear or CBC in a blood tube containing other anticoagulants than EDTA (such as citrate or heparin). Therefore the increase in MPV may indicate a diagnosis of ITP rather than EDTA-PTCP. To make a more definite recommendation on this issue, studies involving more patients are needed.

Kaynakça

  • 1. Jali AGP, Nkambule BB. Prevalence and etiology of moderate and severe thrombocytopenia in a tertiary and quaternary centre in KwaZulu-Natal. Afr J Lab Med. 2020;9(1):799. doi: 10.4102/ajlm.v9i1.799
  • 2. Hillman RS, Ault KA, Leporrier M, Rinder HM. Thrombocytopenia. Hematology in Clinical Practice, 5e. New York, NY: McGraw-Hill Medical; 2016.
  • 3. Berkman N, Michaeli Y, Or R, Eldor A. EDTA-dependent pseudothrombocytopenia: a clinical study of 18 patients and a review of the literature. Am J Hematol. 1991;36(3):195-201. doi: 10.1002/ajh.2830360307
  • 4. Lin J, Luo Y, Yao S, Yan M, Li J, Ouyang W, et al. Discovery and correction of spurious low platelet counts due to EDTA‐dependent pseudothrombocytopenia. J Clin Lab Anal. 2015;29(5):419-26. doi: 10.1002/jcla.21818
  • 5. Lau LG, Chng WJJT. Unnecessary transfusions due to pseudothrombocytopenia: Transfusion medicine illustrated. Transfusion. 2004;44(6):801. doi: 10.1111/j.1537-2995.2004.04009.x
Toplam 5 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hematoloji
Bölüm Araştırma Makaleleri
Yazarlar

Işıl Erdoğan Özünal Bu kişi benim 0000-0002-5289-7134

Yayımlanma Tarihi 30 Ağustos 2022
Gönderilme Tarihi 14 Şubat 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

Vancouver Erdoğan Özünal I. Diagnostic role of platelet indices and leukocyte count in pseudothrombocytopenia. DEU Tıp Derg. 2022;36(2):113-22.