Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Öz

Objective: Seroma formation is one of the most frequent complications following breast cancer surgery. Although many techniques and drugs have been investigated, no definitive data are available concerning how to prevent this complication. The present study aims to investigate impact of local clinoptilolite application on seroma formation in an experimental mastectomy model created in rats.

Material and Method: Two groups with seven rats in each were randomised. Under general anesthesia, all rats underwent right mastectomy and axillary dissection. Clinoptilolite was locally applied to surgical sites in the study group, whereas no application was performed in the control group. Ten days after the surgery, seroma formation was evaluated and tissue samples were obtained from the surgical sites, for both biochemical and histopathological examination

Results: There was statistically significant decrease in seroma formation after clinoptilolite application (p=0.002). In addition, granulation tissue formation was significantly higher in the study group (p=0.006). No statistical difference was found between groups in terms of biochemical parameters.

Conclusion: The reducing effect of seroma formation by clinoptilolite application may be due to its crystal cage structure. It collects seroma with its sero-absorbent features and creates granuloma formation that reduces dead- space, therefore accelarating wound healing.

Anahtar Kelimeler

• seroma,mastectomy,clinoptilolite,wound healing

RATLARDA MASTEKTOMİ VE AKSİLLER DİSSEKSİYON SONRASI KLİNOPTİLOLİT (FROKSİMUN®) KULLANIMININ SEROMA OLUŞUMUNA ETKİSİ

Öz

Amaç: Seroma oluşumu, meme kanseri cerrahisini takiben en sık görülen komplikasyonlardan biridir. Birçok teknik ve ilaç araştırılmasına rağmen bu komplikasyonun nasıl önleneceğine dair kesin bir veri bulunmamaktadır. Bu çalışmada, sıçanlarda oluşturulan deneysel mastektomi modelinde, lokal klinoptilolit uygulamasının seroma formasyonu üzerindeki etkisinin araştırılması amaçlanmıştır.Gereç ve Yöntem: Çalışmamızda, sıçanlar çalışma grubu (n=7) ve kontrol grubu (n=7) olarak iki gruba randomize edildi. Genel anestezi altında tüm sıçanlara sağ mastektomi ve aksiller disseksiyon yapıldı. Çalışma grubuna lokal olarak klinoptilolit uygulanırken, kontrol grubuna herhangi bir uygulama yapılmadı. Ameliyattan on gün sonra, seroma formasyonu değerlendirildi ve hem biyokimyasal hem de histopatolojik incelemeler için cerrahi alanlardan doku örnekleri alındı.

Bulgular: Klinoptilolit uygulanan çalışma grubunda, kontrol grubuna göre seroma oluşumunda istatistiksel olarak anlamlı azalma saptandı (p = 0,002). Ek olarak, çalışma grubunda granülasyon dokusu oluşumu anlamlı olarak daha yüksekti (p = 0,006). Biyokimyasal parametreler açısından gruplar arasında istatistiksel bir fark bulunmadı.

Sonuç: Seroma oluşumunun klinoptilolit uygulaması sonrası azalması, kristal kafes yapısına bağlı olabilir. Sero-emici özellikleriyle seromayı toplar ve ölü boşluğu azaltan, dolayısıyla yara iyileşmesini hızlandıran granülom yapılarını oluşturur.

Anahtar Kelimeler

• seroma,mastektomi,klinoptilolit,yara iyileşmesi

Kaynakça

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